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CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection.

Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D.

J Exp Med. 2013 Sep 23;210(10):1919-27. doi: 10.1084/jem.20122300. Epub 2013 Aug 26.


In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kühn R, Müller W, Trinchieri G, Sher A.

J Immunol. 1996 Jul 15;157(2):798-805.


Adoptive transfer of CD4(+)Foxp3(+) regulatory T cells to C57BL/6J mice during acute infection with Toxoplasma gondii down modulates the exacerbated Th1 immune response.

Olguín JE, Fernández J, Salinas N, Juárez I, Rodriguez-Sosa M, Campuzano J, Castellanos C, Saavedra R.

Microbes Infect. 2015 Aug;17(8):586-95. doi: 10.1016/j.micinf.2015.04.002. Epub 2015 Apr 18.


CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection.

Cohen SB, Maurer KJ, Egan CE, Oghumu S, Satoskar AR, Denkers EY.

PLoS Pathog. 2013;9(10):e1003706. doi: 10.1371/journal.ppat.1003706. Epub 2013 Oct 10.


IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection.

Stumhofer JS, Silver JS, Hunter CA.

PLoS One. 2013 May 7;8(5):e62889. doi: 10.1371/journal.pone.0062889. Print 2013.


Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A.

J Exp Med. 2007 Feb 19;204(2):273-83. Epub 2007 Feb 5.


CD73-generated adenosine is critical for immune regulation during Toxoplasma gondii infection.

Mahamed DA, Toussaint LE, Bynoe MS.

Infect Immun. 2015 Feb;83(2):721-9. doi: 10.1128/IAI.02536-14. Epub 2014 Dec 1.


CCR7-dependent immunity during acute Toxoplasma gondii infection.

Noor S, Habashy AS, Nance JP, Clark RT, Nemati K, Carson MJ, Wilson EH.

Infect Immun. 2010 May;78(5):2257-63. doi: 10.1128/IAI.01314-09. Epub 2010 Mar 1.


T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection.

López-Yglesias AH, Burger E, Araujo A, Martin AT, Yarovinsky F.

Mucosal Immunol. 2018 May;11(3):921-931. doi: 10.1038/mi.2017.102. Epub 2018 Jan 3.


Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.

Caetano BC, Biswas A, Lima DS Jr, Benevides L, Mineo TW, Horta CV, Lee KH, Silva JS, Gazzinelli RT, Zamboni DS, Kobayashi KS.

Eur J Immunol. 2011 Dec;41(12):3627-31. doi: 10.1002/eji.201141876. Epub 2011 Nov 10.


NK cells help to induce CD8(+)-T-cell immunity against Toxoplasma gondii in the absence of CD4(+) T cells.

Combe CL, Curiel TJ, Moretto MM, Khan IA.

Infect Immun. 2005 Aug;73(8):4913-21.


Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta.

Nishanth G, Sakowicz-Burkiewicz M, Händel U, Kliche S, Wang X, Naumann M, Deckert M, Schlüter D.

Infect Immun. 2010 Aug;78(8):3454-64. doi: 10.1128/IAI.01407-09. Epub 2010 May 24.


Toxoplasma gondii infection inhibits Th17-mediated spontaneous development of arthritis in interleukin-1 receptor antagonist-deficient mice.

Washino T, Moroda M, Iwakura Y, Aosai F.

Infect Immun. 2012 Apr;80(4):1437-44. doi: 10.1128/IAI.05680-11. Epub 2012 Jan 30.


IL-10 production by CD4+ effector T cells: a mechanism for self-regulation.

Jankovic D, Kugler DG, Sher A.

Mucosal Immunol. 2010 May;3(3):239-46. doi: 10.1038/mi.2010.8. Epub 2010 Mar 3. Review.


DNA immunization with eukaryotic initiation factor-2α of Toxoplasma gondii induces protective immunity against acute and chronic toxoplasmosis in mice.

Chen J, Huang SY, Zhou DH, Li ZY, Petersen E, Song HQ, Zhu XQ.

Vaccine. 2013 Dec 16;31(52):6225-31. doi: 10.1016/j.vaccine.2013.10.034. Epub 2013 Oct 31.


IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii.

Wille U, Nishi M, Lieberman L, Wilson EH, Roos DS, Hunter CA.

Parasite Immunol. 2004 May;26(5):229-36.


Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.

Béla SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT.

Infect Immun. 2012 Dec;80(12):4298-308. doi: 10.1128/IAI.00328-12. Epub 2012 Oct 1.

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