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Items: 1 to 20 of 103


The TREX1 C-terminal region controls cellular localization through ubiquitination.

Orebaugh CD, Fye JM, Harvey S, Hollis T, Wilkinson JC, Perrino FW.

J Biol Chem. 2013 Oct 4;288(40):28881-92. doi: 10.1074/jbc.M113.503391.


The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.

Orebaugh CD, Fye JM, Harvey S, Hollis T, Perrino FW.

J Biol Chem. 2011 Nov 18;286(46):40246-54. doi: 10.1074/jbc.M111.297903.


The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.

Fye JM, Coffin SR, Orebaugh CD, Hollis T, Perrino FW.

J Biol Chem. 2014 Apr 18;289(16):11556-65. doi: 10.1074/jbc.M114.559252.


Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.

Fye JM, Orebaugh CD, Coffin SR, Hollis T, Perrino FW.

J Biol Chem. 2011 Sep 16;286(37):32373-82. doi: 10.1074/jbc.M111.276287.


Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.

Bailey SL, Harvey S, Perrino FW, Hollis T.

DNA Repair (Amst). 2012 Jan 2;11(1):65-73. doi: 10.1016/j.dnarep.2011.10.007.


Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.

Gray EE, Treuting PM, Woodward JJ, Stetson DB.

J Immunol. 2015 Sep 1;195(5):1939-43. doi: 10.4049/jimmunol.1500969.


The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.

Lehtinen DA, Harvey S, Mulcahy MJ, Hollis T, Perrino FW.

J Biol Chem. 2008 Nov 14;283(46):31649-56. doi: 10.1074/jbc.M806155200.


Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.

Lindahl T, Barnes DE, Yang YG, Robins P.

Biochem Soc Trans. 2009 Jun;37(Pt 3):535-8. doi: 10.1042/BST0370535.


Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.

Brucet M, Querol-Audí J, Serra M, Ramirez-Espain X, Bertlik K, Ruiz L, Lloberas J, Macias MJ, Fita I, Celada A.

J Biol Chem. 2007 May 11;282(19):14547-57.


Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.

Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5117-22. doi: 10.1073/pnas.1423804112.


Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.

Yuan F, Dutta T, Wang L, Song L, Gu L, Qian L, Benitez A, Ning S, Malhotra A, Deutscher MP, Zhang Y.

J Biol Chem. 2015 May 22;290(21):13344-53. doi: 10.1074/jbc.M115.653915.


The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.

de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T.

J Biol Chem. 2007 Apr 6;282(14):10537-43.


Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N.

Nat Genet. 2007 Sep;39(9):1065-7.


Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.

Brucet M, Querol-Audí J, Bertlik K, Lloberas J, Fita I, Celada A.

Protein Sci. 2008 Dec;17(12):2059-69. doi: 10.1110/ps.036426.108.


TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

Ablasser A, Hemmerling I, Schmid-Burgk JL, Behrendt R, Roers A, Hornung V.

J Immunol. 2014 Jun 15;192(12):5993-7. doi: 10.4049/jimmunol.1400737.


Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.

Rice G, Newman WG, Dean J, Patrick T, Parmar R, Flintoff K, Robins P, Harvey S, Hollis T, O'Hara A, Herrick AL, Bowden AP, Perrino FW, Lindahl T, Barnes DE, Crow YJ.

Am J Hum Genet. 2007 Apr;80(4):811-5.


Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient.

Olivieri I, Cattalini M, Tonduti D, La Piana R, Uggetti C, Galli J, Meini A, Tincani A, Moratto D, Fazzi E, Balottin U, Orcesi S.

Lupus. 2013 Sep;22(10):1064-9. doi: 10.1177/0961203313498800.


Human disease phenotypes associated with mutations in TREX1.

Rice GI, Rodero MP, Crow YJ.

J Clin Immunol. 2015 Apr;35(3):235-43. doi: 10.1007/s10875-015-0147-3. Review.


Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.

Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705. doi: 10.1073/pnas.1516465112.

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