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Items: 1 to 20 of 259

1.

Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.

Lumen AA, Li L, Li J, Ahmed Z, Meng Z, Owen A, Ellens H, Hidalgo IJ, Bentz J.

PLoS One. 2013 Aug 16;8(8):e69394. doi: 10.1371/journal.pone.0069394. eCollection 2013.

2.

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

Acharya P, O'Connor MP, Polli JW, Ayrton A, Ellens H, Bentz J.

Drug Metab Dispos. 2008 Feb;36(2):452-60. Epub 2007 Oct 29.

3.
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Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm.

Agnani D, Acharya P, Martinez E, Tran TT, Abraham F, Tobin F, Ellens H, Bentz J.

PLoS One. 2011;6(10):e25086. doi: 10.1371/journal.pone.0025086. Epub 2011 Oct 18.

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P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

Acharya P, Tran TT, Polli JW, Ayrton A, Ellens H, Bentz J.

Biochemistry. 2006 Dec 26;45(51):15505-19. Epub 2006 Nov 30.

PMID:
17176072
8.

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG.

Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4.

9.

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Liu PQ, Duan W, Chowbay B, Wen JY, Li CG, Zhou SF.

Curr Drug Metab. 2007 May;8(4):325-40.

PMID:
17504222
10.
11.

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

Tang F, Horie K, Borchardt RT.

Pharm Res. 2002 Jun;19(6):765-72.

PMID:
12134945
12.

Influence of passive permeability on apparent P-glycoprotein kinetics.

Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE.

Pharm Res. 2000 Dec;17(12):1456-60.

PMID:
11303953
13.

A structural model for the mass action kinetic analysis of P-gp mediated transport through confluent cell monolayers.

Bentz J, Ellens H.

Methods Mol Biol. 2014;1113:289-316. doi: 10.1007/978-1-62703-758-7_14.

PMID:
24523118
14.

Quantitative investigation of the impact of P-glycoprotein inhibition on drug transport across blood-brain barrier in rats.

Sugimoto H, Hirabayashi H, Kimura Y, Furuta A, Amano N, Moriwaki T.

Drug Metab Dispos. 2011 Jan;39(1):8-14. doi: 10.1124/dmd.110.035774. Epub 2010 Oct 20.

16.

Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models.

Fan Y, Rodriguez-Proteau R.

Xenobiotica. 2008 Feb;38(2):107-29. doi: 10.1080/00498250701744625 .

PMID:
18197554
17.

Amino acid prodrug of quinidine: an approach to circumvent P-glycoprotein mediated cellular efflux.

Patel M, Mandava NK, Pal D, Mitra AK.

Int J Pharm. 2014 Apr 10;464(1-2):196-204. doi: 10.1016/j.ijpharm.2014.01.006. Epub 2014 Jan 17.

PMID:
24440401
18.

Circumventing P-glycoprotein-mediated cellular efflux of quinidine by prodrug derivatization.

Jain R, Majumdar S, Nashed Y, Pal D, Mitra AK.

Mol Pharm. 2004 Jul-Aug;1(4):290-9.

PMID:
15981588
19.

Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux.

Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H.

Pharmacol Res. 2010 Jan;61(1):76-84. doi: 10.1016/j.phrs.2009.07.002. Epub 2009 Jul 21.

PMID:
19631272
20.

The complexity of intestinal absorption and exsorption of digoxin in rats.

Yao HM, Chiou WL.

Int J Pharm. 2006 Sep 28;322(1-2):79-86. Epub 2006 May 22.

PMID:
16781832

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