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Items: 1 to 20 of 152

1.

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells.

Zhang Y, Maksimovic J, Naselli G, Qian J, Chopin M, Blewitt ME, Oshlack A, Harrison LC.

Blood. 2013 Oct 17;122(16):2823-36. doi: 10.1182/blood-2013-02-481788. Epub 2013 Aug 23.

2.

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.

Polansky JK, Schreiber L, Thelemann C, Ludwig L, Krüger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J.

J Mol Med (Berl). 2010 Oct;88(10):1029-40. doi: 10.1007/s00109-010-0642-1. Epub 2010 Jun 24.

3.

Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells.

Morikawa H, Sakaguchi S.

Immunol Rev. 2014 May;259(1):192-205. doi: 10.1111/imr.12174. Review.

PMID:
24712467
4.

FOXP3 promoter demethylation reveals the committed Treg population in humans.

Janson PC, Winerdal ME, Marits P, Thörn M, Ohlsson R, Winqvist O.

PLoS One. 2008 Feb 20;3(2):e1612. doi: 10.1371/journal.pone.0001612.

5.

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, Thiel A, Boeld TJ, Hoffmann P, Edinger M, Türbachova I, Hamann A, Olek S, Huehn J.

Eur J Immunol. 2007 Sep;37(9):2378-89.

6.

Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells.

Nagar M, Vernitsky H, Cohen Y, Dominissini D, Berkun Y, Rechavi G, Amariglio N, Goldstein I.

Int Immunol. 2008 Aug;20(8):1041-55. doi: 10.1093/intimm/dxn062. Epub 2008 Jun 20.

PMID:
18567616
7.

Revisiting regulatory T cells in type 1 diabetes.

Zhang Y, Bandala-Sanchez E, Harrison LC.

Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):271-8. doi: 10.1097/MED.0b013e328355a2d5. Review.

PMID:
22732485
8.

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, Olek S, Dietmaier W, Andreesen R, Edinger M.

Eur J Immunol. 2009 Apr;39(4):1088-97. doi: 10.1002/eji.200838904.

9.

Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.

Wang L, Liu Y, Han R, Beier UH, Thomas RM, Wells AD, Hancock WW.

Mol Cell Biol. 2013 Oct;33(20):4106-15. doi: 10.1128/MCB.00144-13. Epub 2013 Aug 26.

10.

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Pion M, Jaramillo-Ruiz D, Martínez A, Muñoz-Fernández MA, Correa-Rocha R.

AIDS. 2013 Aug 24;27(13):2019-29. doi: 10.1097/QAD.0b013e32836253fd.

PMID:
24201117
11.

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.

Schmidl C, Klug M, Boeld TJ, Andreesen R, Hoffmann P, Edinger M, Rehli M.

Genome Res. 2009 Jul;19(7):1165-74. doi: 10.1101/gr.091470.109. Epub 2009 Jun 3.

12.

Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia.

Shimazu Y, Shimazu Y, Hishizawa M, Hamaguchi M, Nagai Y, Sugino N, Fujii S, Kawahara M, Kadowaki N, Nishikawa H, Sakaguchi S, Takaori-Kondo A.

Cancer Immunol Res. 2016 Feb;4(2):136-45. doi: 10.1158/2326-6066.CIR-15-0148. Epub 2015 Dec 17.

13.

Epigenetic mechanisms of regulation of Foxp3 expression.

Lal G, Bromberg JS.

Blood. 2009 Oct 29;114(18):3727-35. doi: 10.1182/blood-2009-05-219584. Epub 2009 Jul 29. Review.

14.

Regulatory T cells in cancer: an overview and perspectives on cyclooxygenase-2 and Foxp3 DNA methylation.

Sahin M, Sahin E, Koksoy S.

Hum Immunol. 2013 Sep;74(9):1061-8. doi: 10.1016/j.humimm.2013.05.009. Epub 2013 Jun 10. Review.

PMID:
23756166
15.

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger EP, Reid SP, Levy DE, Bromberg JS.

J Immunol. 2009 Jan 1;182(1):259-73.

16.

Genome-wide identification of human FOXP3 target genes in natural regulatory T cells.

Sadlon TJ, Wilkinson BG, Pederson S, Brown CY, Bresatz S, Gargett T, Melville EL, Peng K, D'Andrea RJ, Glonek GG, Goodall GJ, Zola H, Shannon MF, Barry SC.

J Immunol. 2010 Jul 15;185(2):1071-81. doi: 10.4049/jimmunol.1000082. Epub 2010 Jun 16.

17.

Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells.

Tian Y, Jia Z, Wang J, Huang Z, Tang J, Zheng Y, Tang Y, Wang Q, Tian Z, Yang D, Zhang Y, Fu X, Song J, Liu S, van Velkinburgh JC, Wu Y, Ni B.

PLoS One. 2011;6(11):e27770. doi: 10.1371/journal.pone.0027770. Epub 2011 Nov 23.

18.

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5289-94. doi: 10.1073/pnas.1312717110. Epub 2014 Mar 27.

19.

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, Uchiyama T, Sakaguchi S.

Int Immunol. 2006 Aug;18(8):1197-209. Epub 2006 Jun 13.

PMID:
16772372
20.

DNA methylation controls Foxp3 gene expression.

Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J.

Eur J Immunol. 2008 Jun;38(6):1654-63. doi: 10.1002/eji.200838105.

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