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E2F-7 couples DNA damage-dependent transcription with the DNA repair process.

Zalmas LP, Coutts AS, Helleday T, La Thangue NB.

Cell Cycle. 2013 Sep 15;12(18):3037-51. doi: 10.4161/cc.26078. Epub 2013 Aug 20.


Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression.

Liu B, Shats I, Angus SP, Gatza ML, Nevins JR.

J Biol Chem. 2013 Aug 23;288(34):24581-9. doi: 10.1074/jbc.M113.467506. Epub 2013 Jul 13.


DNA-damage response control of E2F7 and E2F8.

Zalmas LP, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB.

EMBO Rep. 2008 Mar;9(3):252-9. doi: 10.1038/sj.embor.7401158. Epub 2008 Jan 18.


E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

Ingram L, Munro S, Coutts AS, La Thangue NB.

Cell Death Differ. 2011 Jan;18(1):122-32. doi: 10.1038/cdd.2010.70. Epub 2010 Jun 18.


E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.

Carvajal LA, Hamard PJ, Tonnessen C, Manfredi JJ.

Genes Dev. 2012 Jul 15;26(14):1533-45. doi: 10.1101/gad.184911.111.


Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.

Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MS, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L, Lin J, Höti N, Nortier JW, DeWeese TL, Hammers H, Carducci MA.

PLoS One. 2010 Jun 18;5(6):e11208. doi: 10.1371/journal.pone.0011208.


The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, Lowe SW.

Genes Dev. 2012 Jul 15;26(14):1546-57. doi: 10.1101/gad.196238.112.


Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.

Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ.

J Cell Biol. 2003 Mar 31;160(7):1017-27.


E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.

Logan N, Delavaine L, Graham A, Reilly C, Wilson J, Brummelkamp TR, Hijmans EM, Bernards R, La Thangue NB.

Oncogene. 2004 Jul 1;23(30):5138-50.


Polo-like kinase 1 inhibits DNA damage response during mitosis.

Benada J, Burdová K, Lidak T, von Morgen P, Macurek L.

Cell Cycle. 2015;14(2):219-31. doi: 10.4161/15384101.2014.977067.


ANTI-SILENCING FUNCTION1 proteins are involved in ultraviolet-induced DNA damage repair and are cell cycle regulated by E2F transcription factors in Arabidopsis.

Lario LD, Ramirez-Parra E, Gutierrez C, Spampinato CP, Casati P.

Plant Physiol. 2013 Jun;162(2):1164-77. doi: 10.1104/pp.112.212837. Epub 2013 Apr 17. Erratum in: Plant Physiol. 2013 Dec;163(4):1883.


The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM.

Zirkin S, Davidovich A, Don J.

J Biol Chem. 2013 Jul 26;288(30):21770-83. doi: 10.1074/jbc.M113.458851. Epub 2013 Jun 11.


E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer.

Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu Y.

Oncogene. 2006 Jan 12;25(2):230-9.


Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response.

Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T.

Biochem Biophys Res Commun. 2012 Apr 27;421(1):57-63. doi: 10.1016/j.bbrc.2012.03.108. Epub 2012 Mar 29.


Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.

Chan HM, Smith L, La Thangue NB.

Oncogene. 2001 Sep 27;20(43):6152-63.


Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W.

J Cell Biol. 2009 Sep 21;186(6):835-47. doi: 10.1083/jcb.200902150.


p53-dependent down-regulation of telomerase is mediated by p21waf1.

Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D, Rotter V.

J Biol Chem. 2004 Dec 3;279(49):50976-85. Epub 2004 Sep 15.


p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.

Tophkhane C, Yang SH, Jiang Y, Ma Z, Subramaniam D, Anant S, Yogosawa S, Sakai T, Liu WG, Edgerton S, Thor A, Yang X.

PLoS One. 2012;7(8):e43564. doi: 10.1371/journal.pone.0043564. Epub 2012 Aug 30.


Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice.

Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S.

Mol Cell. 2014 Feb 20;53(4):617-30. doi: 10.1016/j.molcel.2014.01.030.

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