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Items: 1 to 20 of 325

1.

The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria.

Matissek KJ, Mossalam M, Okal A, Lim CS.

Mol Pharm. 2013 Oct 7;10(10):3592-602. doi: 10.1021/mp400380s. Epub 2013 Sep 6.

PMID:
23968395
2.

Direct induction of apoptosis using an optimal mitochondrially targeted p53.

Mossalam M, Matissek KJ, Okal A, Constance JE, Lim CS.

Mol Pharm. 2012 May 7;9(5):1449-58. doi: 10.1021/mp3000259. Epub 2012 Mar 28.

3.

Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.

Matissek KJ, Okal A, Mossalam M, Lim CS.

Pharm Res. 2014 Sep;31(9):2503-15. doi: 10.1007/s11095-014-1346-y. Epub 2014 Mar 15.

4.

p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.

5.

The DNA-binding domain mediates both nuclear and cytosolic functions of p53.

Follis AV, Llambi F, Ou L, Baran K, Green DR, Kriwacki RW.

Nat Struct Mol Biol. 2014 Jun;21(6):535-43. doi: 10.1038/nsmb.2829. Epub 2014 May 11.

6.
7.

CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.

Liu Y, Clegg HV, Leslie PL, Di J, Tollini LA, He Y, Kim TH, Jin A, Graves LM, Zheng J, Zhang Y.

Cell Death Differ. 2015 Jun;22(6):1035-46. doi: 10.1038/cdd.2014.194. Epub 2014 Dec 5.

8.

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis.

Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):E1839-48. doi: 10.1073/pnas.1208530110. Epub 2013 Apr 15.

9.

A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas.

Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT, Van Waes C, Chen Z.

Int J Cancer. 2008 May 1;122(9):1987-98. doi: 10.1002/ijc.23324.

10.
11.

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.

12.

Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.

Niture SK, Jaiswal AK.

J Biol Chem. 2011 Dec 30;286(52):44542-56. doi: 10.1074/jbc.M111.275073. Epub 2011 Nov 9. Retraction in: J Biol Chem. 2014 Aug 8;289(32):22019.

13.

Anti-apoptotic genes Bcl-2 and Bcl-xL overexpression can block iridovirus serine/threonine kinase-induced Bax/mitochondria-mediated cell death in GF-1 cells.

Reshi L, Wang HV, Hui CF, Su YC, Hong JR.

Fish Shellfish Immunol. 2017 Feb;61:120-129. doi: 10.1016/j.fsi.2016.12.026. Epub 2016 Dec 23.

PMID:
28025159
14.

Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim.

Han J, Goldstein LA, Hou W, Gastman BR, Rabinowich H.

J Biol Chem. 2010 Jul 16;285(29):22473-83. doi: 10.1074/jbc.M109.081042. Epub 2010 Apr 19.

15.

Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53.

Ho TF, Ma CJ, Lu CH, Tsai YT, Wei YH, Chang JS, Lai JK, Cheuh PJ, Yeh CT, Tang PC, Tsai Chang J, Ko JL, Liu FS, Yen HE, Chang CC.

Toxicol Appl Pharmacol. 2007 Dec 15;225(3):318-28. Epub 2007 Aug 22.

PMID:
17881028
16.

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J.

J Biol Chem. 2014 Apr 25;289(17):11873-96. doi: 10.1074/jbc.M114.552562. Epub 2014 Mar 10.

17.

The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl.

Xu H, Tai J, Ye H, Kang CB, Yoon HS.

Biochem Biophys Res Commun. 2006 Mar 24;341(4):938-44. Epub 2006 Jan 23.

PMID:
16455050
19.

Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.

Gogada R, Prabhu V, Amadori M, Scott R, Hashmi S, Chandra D.

J Biol Chem. 2011 Aug 19;286(33):28749-60. doi: 10.1074/jbc.M110.202440. Epub 2011 Jun 28.

20.

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.

Kim EM, Park JK, Hwang SG, Kim WJ, Liu ZG, Kang SW, Um HD.

Oncotarget. 2014 Sep 30;5(18):8452-65.

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