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Items: 1 to 20 of 138

1.

Visualization of hypoxia-inducible factor 1α-p300 interactions in live cells by fluorescence resonance energy transfer.

Kim SY, Lee MJ, Na YR, Kim SY, Yang EG.

J Cell Biochem. 2014 Feb;115(2):271-80. doi: 10.1002/jcb.24659.

PMID:
23966271
2.

Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300.

Na YR, Han KC, Park H, Yang EG.

Biochem Biophys Res Commun. 2013 May 17;434(4):879-84. doi: 10.1016/j.bbrc.2013.04.044. Epub 2013 Apr 22.

PMID:
23618863
3.

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.

Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, Venzon DJ, Liewehr DJ, Chau CH, Price DK, Figg WD.

Mol Cancer. 2014 Apr 28;13:91. doi: 10.1186/1476-4598-13-91.

4.

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, Pereira T, Poellinger L.

J Biol Chem. 2010 Jan 22;285(4):2601-9. doi: 10.1074/jbc.M109.021824. Epub 2009 Oct 30.

5.
6.

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.

PMID:
25892103
7.

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α.

Yoon H, Lim JH, Cho CH, Huang LE, Park JW.

Biochim Biophys Acta. 2011 Dec;1813(12):2008-16. doi: 10.1016/j.bbamcr.2011.08.018. Epub 2011 Sep 8.

8.

EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.

Chen Z, Liu X, Mei Z, Wang Z, Xiao W.

Mol Cell Biol. 2014 Mar;34(6):1085-99. doi: 10.1128/MCB.00718-13. Epub 2014 Jan 13.

9.

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.

Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner-Pfannschmidt U, Fandrey J, Wenger RH, Stiehl DP.

Nucleic Acids Res. 2012 Mar;40(5):1928-43. doi: 10.1093/nar/gkr978. Epub 2011 Nov 10.

10.

[Development of a novel screening assay for inhibitors targeting HIF-1alpha and P300 interaction].

Lai FF, Niu F, Yang HZ, Zhou WQ, Chen XG.

Yao Xue Xue Bao. 2014 Jun;49(6):849-53. Chinese.

PMID:
25212031
11.

Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, Nicolaou KC, Van Meir EG.

Clin Cancer Res. 2012 Dec 15;18(24):6623-33. doi: 10.1158/1078-0432.CCR-12-0861. Epub 2012 Aug 24.

12.

Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.

Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, Ahn DR.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5249-52. doi: 10.1016/j.bmcl.2012.06.054. Epub 2012 Jun 23.

PMID:
22789427
13.

NF-κB suppresses HIF-1α response by competing for P300 binding.

Mendonça DB, Mendonça G, Aragão FJ, Cooper LF.

Biochem Biophys Res Commun. 2011 Jan 28;404(4):997-1003. doi: 10.1016/j.bbrc.2010.12.098. Epub 2010 Dec 25.

PMID:
21187066
14.

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.

15.

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E.

J Biol Chem. 2015 Aug 7;290(32):19726-42. doi: 10.1074/jbc.M115.653014. Epub 2015 Jun 25.

17.

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J.

J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26.

18.

Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells.

Yoshida T, Hashimura M, Mastumoto T, Tazo Y, Inoue H, Kuwata T, Saegusa M.

Lab Invest. 2013 Nov;93(11):1184-93. doi: 10.1038/labinvest.2013.111. Epub 2013 Sep 16.

19.

Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha.

Shin DH, Li SH, Yang SW, Lee BL, Lee MK, Park JW.

FEBS J. 2009 Jul;276(13):3470-80. doi: 10.1111/j.1742-4658.2009.07069.x. Epub 2009 May 18.

20.

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2004 Mar 12;279(11):9899-904. Epub 2003 Dec 29.

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