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Items: 1 to 20 of 123


Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor.

Bergmayr C, Thurner P, Keuerleber S, Kudlacek O, Nanoff C, Freissmuth M, Gruber CW.

J Biol Chem. 2013 Oct 4;288(40):28831-44. doi: 10.1074/jbc.M113.464776. Epub 2013 Aug 21.


A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8.


Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.

Carrello A, Allan RK, Morgan SL, Owen BA, Mok D, Ward BK, Minchin RF, Toft DO, Ratajczak T.

Cell Stress Chaperones. 2004 Summer;9(2):167-81.


C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.

Muller P, Ruckova E, Halada P, Coates PJ, Hrstka R, Lane DP, Vojtesek B.

Oncogene. 2013 Jun 20;32(25):3101-10. doi: 10.1038/onc.2012.314. Epub 2012 Jul 23.


The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.

Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Höhfeld J, Patterson C.

Nat Cell Biol. 2001 Jan;3(1):93-6.


Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes.

Zhang X, Qian SB.

Mol Biol Cell. 2011 Sep;22(18):3277-88. doi: 10.1091/mbc.E11-05-0388. Epub 2011 Jul 20.


Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE.

Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25.


Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis.

Donnelly BF, Needham PG, Snyder AC, Roy A, Khadem S, Brodsky JL, Subramanya AR.

J Biol Chem. 2013 May 3;288(18):13124-35. doi: 10.1074/jbc.M113.455394. Epub 2013 Mar 12.


The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

Meimaridou E, Gooljar SB, Ramnarace N, Anthonypillai L, Clark AJ, Chapple JP.

Mol Endocrinol. 2011 Sep;25(9):1650-60. doi: 10.1210/me.2011-1020. Epub 2011 Jun 30.


Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

Pratt WB, Toft DO.

Exp Biol Med (Maywood). 2003 Feb;228(2):111-33. Review.


The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system.

Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH.

Mol Biol Cell. 2007 Jan;18(1):153-65. Epub 2006 Oct 25.


Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.

Gao Y, Yechikov S, Vazquez AE, Chen D, Nie L.

PLoS One. 2013;8(2):e57282. doi: 10.1371/journal.pone.0057282. Epub 2013 Feb 19.


Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.

Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP.

J Biol Chem. 2010 May 21;285(21):15714-23. doi: 10.1074/jbc.M109.098806. Epub 2010 Mar 26.


Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.

Kanelakis KC, Morishima Y, Dittmar KD, Galigniana MD, Takayama S, Reed JC, Pratt WB.

J Biol Chem. 1999 Nov 26;274(48):34134-40.


Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.

Kubota H, Yamamoto S, Itoh E, Abe Y, Nakamura A, Izumi Y, Okada H, Iida M, Nanjo H, Itoh H, Yamamoto Y.

Cell Stress Chaperones. 2010 Nov;15(6):1003-11. doi: 10.1007/s12192-010-0211-0. Epub 2010 Jul 9.


Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.

Peng HM, Morishima Y, Pratt WB, Osawa Y.

J Biol Chem. 2012 Jan 6;287(2):1556-65. doi: 10.1074/jbc.M111.323295. Epub 2011 Nov 28.


Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.

Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP.

Annu Rev Pharmacol Toxicol. 2015;55:353-71. doi: 10.1146/annurev-pharmtox-010814-124332. Epub 2014 Sep 25. Review.

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