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Items: 1 to 20 of 73

1.

Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs.

Wang YT, Hsu HJ, Fischer WB.

Springerplus. 2013 Jul 18;2:324. doi: 10.1186/2193-1801-2-324. eCollection 2013.

2.

Docking assay of small molecule antivirals to p7 of HCV.

Bichmann L, Wang YT, Fischer WB.

Comput Biol Chem. 2014 Nov 13;53PB:308-317. doi: 10.1016/j.compbiolchem.2014.11.001. [Epub ahead of print]

PMID:
25462337
3.

Understanding the inhibitory mechanism of BIT225 drug against p7 viroporin using computational study.

Behmard E, Abdolmaleki P, Taghdir M.

Biophys Chem. 2017 Nov 16. pii: S0301-4622(17)30271-5. doi: 10.1016/j.bpc.2017.11.002. [Epub ahead of print]

PMID:
29169687
4.

The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.

Sakai A, Claire MS, Faulk K, Govindarajan S, Emerson SU, Purcell RH, Bukh J.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11646-51. Epub 2003 Sep 22.

5.

Protein-protein interactions: modeling the hepatitis C virus ion channel p7.

Patargias G, Zitzmann N, Dwek R, Fischer WB.

J Med Chem. 2006 Jan 26;49(2):648-55.

PMID:
16420050
6.

Small molecule ligand docking to genotype specific bundle structures of hepatitis C virus (HCV) p7 protein.

Laasch N, Kalita MM, Griffin S, Fischer WB.

Comput Biol Chem. 2016 Oct;64:56-63. doi: 10.1016/j.compbiolchem.2016.04.010. Epub 2016 May 20.

PMID:
27258799
7.

A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues.

Luscombe CA, Huang Z, Murray MG, Miller M, Wilkinson J, Ewart GD.

Antiviral Res. 2010 May;86(2):144-53. doi: 10.1016/j.antiviral.2010.02.312. Epub 2010 Feb 13.

PMID:
20156486
8.

Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance.

Cook GA, Dawson LA, Tian Y, Opella SJ.

Biochemistry. 2013 Aug 6;52(31):5295-303. doi: 10.1021/bi4006623. Epub 2013 Jul 24.

9.

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel.

Foster TL, Verow M, Wozniak AL, Bentham MJ, Thompson J, Atkins E, Weinman SA, Fishwick C, Foster R, Harris M, Griffin S.

Hepatology. 2011 Jul;54(1):79-90. doi: 10.1002/hep.24371.

PMID:
21520195
10.

NMR structure and ion channel activity of the p7 protein from hepatitis C virus.

Montserret R, Saint N, Vanbelle C, Salvay AG, Simorre JP, Ebel C, Sapay N, Renisio JG, Böckmann A, Steinmann E, Pietschmann T, Dubuisson J, Chipot C, Penin F.

J Biol Chem. 2010 Oct 8;285(41):31446-61. doi: 10.1074/jbc.M110.122895. Epub 2010 Jul 28.

11.

Amino acid variations in hepatitis C virus p7 and sensitivity to antiviral combination therapy with amantadine in chronic hepatitis C.

Mihm U, Grigorian N, Welsch C, Herrmann E, Kronenberger B, Teuber G, von Wagner M, Hofmann WP, Albrecht M, Lengauer T, Zeuzem S, Sarrazin C.

Antivir Ther. 2006;11(4):507-19.

PMID:
16856625
12.
13.

Unusual architecture of the p7 channel from hepatitis C virus.

OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ.

Nature. 2013 Jun 27;498(7455):521-5. doi: 10.1038/nature12283. Epub 2013 Jun 5.

14.
15.

Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro.

StGelais C, Foster TL, Verow M, Atkins E, Fishwick CW, Rowlands D, Harris M, Griffin S.

J Virol. 2009 Aug;83(16):7970-81. doi: 10.1128/JVI.00521-09. Epub 2009 Jun 3.

16.

Sequence alignment of viral channel proteins with cellular ion channels.

Schindler C, Fischer WB.

J Comput Biol. 2012 Sep;19(9):1060-72. doi: 10.1089/cmb.2011.0297. Epub 2012 Aug 14.

PMID:
22891808
17.

The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production.

Scull MA, Schneider WM, Flatley BR, Hayden R, Fung C, Jones CT, van de Belt M, Penin F, Rice CM.

PLoS Pathog. 2015 Nov 20;11(11):e1005297. doi: 10.1371/journal.ppat.1005297. eCollection 2015 Nov.

18.

Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine.

Castelain S, Bonte D, Penin F, François C, Capron D, Dedeurwaerder S, Zawadzki P, Morel V, Wychowski C, Duverlie G.

J Med Virol. 2007 Feb;79(2):144-54.

PMID:
17177298
19.

Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production.

Atoom AM, Jones DM, Russell RS.

Virus Res. 2013 Sep;176(1-2):199-210. doi: 10.1016/j.virusres.2013.06.008. Epub 2013 Jun 28.

20.

Ion-dynamics in hepatitis C virus p7 helical transmembrane domains--a molecular dynamics simulation study.

Wang YT, Schilling R, Fink RH, Fischer WB.

Biophys Chem. 2014 Aug;192:33-40. doi: 10.1016/j.bpc.2014.06.001. Epub 2014 Jun 16.

PMID:
24997299

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