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Items: 1 to 20 of 98

1.

Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.

Spijkers-Hagelstein JA, Pinhanços SS, Schneider P, Pieters R, Stam RW.

Leukemia. 2014 Apr;28(4):761-9. doi: 10.1038/leu.2013.245. Epub 2013 Aug 20.

PMID:
23958920
2.

Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.

Spijkers-Hagelstein JA, Mimoso Pinhanços S, Schneider P, Pieters R, Stam RW.

Leukemia. 2013 Apr;27(5):1063-71. doi: 10.1038/leu.2012.372. Epub 2012 Dec 28.

PMID:
23334362
3.

Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia.

Spijkers-Hagelstein JA, Schneider P, Hulleman E, de Boer J, Williams O, Pieters R, Stam RW.

Leukemia. 2012 Jun;26(6):1255-65. doi: 10.1038/leu.2011.388. Epub 2012 Jan 27.

PMID:
22282267
4.

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.

Stam RW, Den Boer ML, Schneider P, de Boer J, Hagelstein J, Valsecchi MG, de Lorenzo P, Sallan SE, Brady HJ, Armstrong SA, Pieters R.

Blood. 2010 Feb 4;115(5):1018-25. doi: 10.1182/blood-2009-02-205963. Epub 2009 Dec 4.

5.

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia.

Beesley AH, Rampellini JL, Palmer ML, Heng JY, Samuels AL, Firth MJ, Ford J, Kees UR.

Mol Cancer. 2010 Oct 28;9:284. doi: 10.1186/1476-4598-9-284.

6.

Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101.

Spijkers-Hagelstein JA, Schneider P, Pinhanços SM, Garrido Castro P, Pieters R, Stam RW.

Eur J Cancer. 2014 Jun;50(9):1665-74. doi: 10.1016/j.ejca.2014.03.011. Epub 2014 Apr 3.

PMID:
24703900
7.

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.

Driessen EM, van Roon EH, Spijkers-Hagelstein JA, Schneider P, de Lorenzo P, Valsecchi MG, Pieters R, Stam RW.

Haematologica. 2013 Jun;98(6):937-44. doi: 10.3324/haematol.2012.067983. Epub 2013 Feb 12.

8.

Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia.

Schotte D, Lange-Turenhout EA, Stumpel DJ, Stam RW, Buijs-Gladdines JG, Meijerink JP, Pieters R, Den Boer ML.

Haematologica. 2010 Oct;95(10):1675-82. doi: 10.3324/haematol.2010.023481. Epub 2010 May 21.

9.

The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia.

Stumpel DJ, Schneider P, Pieters R, Stam RW.

Eur J Cancer. 2015 Sep;51(14):2008-21. doi: 10.1016/j.ejca.2015.06.117. Epub 2015 Jul 15.

10.

In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype.

Ramakers-van Woerden NL, Beverloo HB, Veerman AJ, Camitta BM, Loonen AH, van Wering ER, Slater RM, Harbott J, den Boer ML, Ludwig WD, Haas OA, Janka-Schaub GE, Pieters R.

Leukemia. 2004 Mar;18(3):521-9.

PMID:
14712291
11.

Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia.

Mata JF, Scrideli CA, Queiroz RP, Mori BO, Emerenciano M, Pombo-de-Oliveira MS, Tone LG.

Braz J Med Biol Res. 2006 Nov;39(11):1417-23.

12.

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.

Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, Janka-Schaub GE, Armstrong SA, Korsmeyer SJ, Pieters R.

Blood. 2003 Feb 15;101(4):1270-6. Epub 2002 Oct 24.

13.

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options.

Stumpel DJ, Schneider P, van Roon EH, Boer JM, de Lorenzo P, Valsecchi MG, de Menezes RX, Pieters R, Stam RW.

Blood. 2009 Dec 24;114(27):5490-8. doi: 10.1182/blood-2009-06-227660. Epub 2009 Oct 23.

14.

miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221.

Kotani A, Ha D, Hsieh J, Rao PK, Schotte D, den Boer ML, Armstrong SA, Lodish HF.

Blood. 2009 Nov 5;114(19):4169-78. doi: 10.1182/blood-2008-12-191619. Epub 2009 Sep 11.

15.

Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia.

Stam RW, den Boer ML, Passier MM, Janka-Schaub GE, Sallan SE, Armstrong SA, Pieters R.

Leukemia. 2006 Feb;20(2):264-71.

PMID:
16357833
16.

Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner.

Brown P, Levis M, McIntyre E, Griesemer M, Small D.

Leukemia. 2006 Aug;20(8):1368-76. Epub 2006 Jun 8.

PMID:
16761017
17.

MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism.

Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P.

Br J Haematol. 2013 Mar;160(6):785-97. doi: 10.1111/bjh.12205. Epub 2013 Jan 7.

18.

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.

Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ, Evans WE, Pieters R, Den Boer ML.

Blood. 2009 Feb 26;113(9):2014-21. doi: 10.1182/blood-2008-05-157842. Epub 2008 Oct 31.

19.

Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia.

Chowdhury T, Brady HJ.

Blood Cells Mol Dis. 2008 Mar-Apr;40(2):192-9. Epub 2007 Oct 1. Review.

PMID:
17905612
20.

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.

Stumpel DJ, Schneider P, Seslija L, Osaki H, Williams O, Pieters R, Stam RW.

Leukemia. 2012 Apr;26(4):682-92. doi: 10.1038/leu.2011.278. Epub 2011 Oct 21.

PMID:
22015773
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