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Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial.

Forrest E, Mellor J, Stanton L, Bowers M, Ryder P, Austin A, Day C, Gleeson D, O'Grady J, Masson S, McCune A, Patch D, Richardson P, Roderick P, Ryder S, Wright M, Thursz M.

Trials. 2013 Aug 19;14:262. doi: 10.1186/1745-6215-14-262.


The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial.

Thursz M, Forrest E, Roderick P, Day C, Austin A, O'Grady J, Ryder S, Allison M, Gleeson D, McCune A, Patch D, Wright M, Masson S, Richardson P, Vale L, Mellor J, Stanton L, Bowers M, Ratcliffe I, Downs N, Kirkman S, Homer T, Ternent L.

Health Technol Assess. 2015 Dec;19(102):1-104. doi: 10.3310/hta191020.


Prednisolone or pentoxifylline for alcoholic hepatitis.

Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial.

N Engl J Med. 2015 Apr 23;372(17):1619-28. doi: 10.1056/NEJMoa1412278.


In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA.

Vergis N, Atkinson SR, Knapp S, Maurice J, Allison M, Austin A, Forrest EH, Masson S, McCune A, Patch D, Richardson P, Gleeson D, Ryder SD, Wright M, Thursz MR.

Gastroenterology. 2017 Apr;152(5):1068-1077.e4. doi: 10.1053/j.gastro.2016.12.019. Epub 2016 Dec 30.


Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial.

Mathurin P, Louvet A, Duhamel A, Nahon P, Carbonell N, Boursier J, Anty R, Diaz E, Thabut D, Moirand R, Lebrec D, Moreno C, Talbodec N, Paupard T, Naveau S, Silvain C, Pageaux GP, Sobesky R, Canva-Delcambre V, Dharancy S, Salleron J, Dao T.

JAMA. 2013 Sep 11;310(10):1033-41. doi: 10.1001/jama.2013.276300.


Pentoxifylline vs. corticosteroid to treat severe alcoholic hepatitis: a randomised, non-inferiority, open trial.

Park SH, Kim DJ, Kim YS, Yim HJ, Tak WY, Lee HJ, Sohn JH, Yoon KT, Kim IH, Kim HS, Um SH, Baik SK, Lee JS, Suk KT, Kim SG, Suh SJ, Park SY, Kim TY, Jang JY; Korean Association for the Study of the Liver (KASL)-Alcohol Related Problems Study Group.

J Hepatol. 2014 Oct;61(4):792-8. doi: 10.1016/j.jhep.2014.05.014. Epub 2014 May 15.


Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis.

Singh S, Murad MH, Chandar AK, Bongiorno CM, Singal AK, Atkinson SR, Thursz MR, Loomba R, Shah VH.

Gastroenterology. 2015 Oct;149(4):958-70.e12. doi: 10.1053/j.gastro.2015.06.006. Epub 2015 Jun 16. Review.


Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MR.

J Hepatol. 2017 Jul;67(1):120-127. doi: 10.1016/j.jhep.2017.01.018. Epub 2017 Feb 2.


Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trial.

De BK, Gangopadhyay S, Dutta D, Baksi SD, Pani A, Ghosh P.

World J Gastroenterol. 2009 Apr 7;15(13):1613-9.


Determinants of long-term outcome in severe alcoholic hepatitis.

Potts JR, Goubet S, Heneghan MA, Verma S.

Aliment Pharmacol Ther. 2013 Sep;38(6):584-95. doi: 10.1111/apt.12427. Epub 2013 Jul 23.


Corticosteroid plus pentoxifylline is not better than corticosteroid alone for improving survival in severe alcoholic hepatitis (COPE trial).

Sidhu SS, Goyal O, Singla P, Gupta D, Sood A, Chhina RS, Soni RK.

Dig Dis Sci. 2012 Jun;57(6):1664-71. doi: 10.1007/s10620-012-2097-4. Epub 2012 Mar 3.


Alcoholic hepatitis: Prognosis and treatment.

Casanova J, Bataller R.

Gastroenterol Hepatol. 2014 Apr;37(4):262-8. doi: 10.1016/j.gastrohep.2014.02.001. Epub 2014 Mar 20. Review.


Pentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial.

Sidhu SS, Goyal O, Singla M, Bhatia KL, Chhina RS, Sood A.

J Assoc Physicians India. 2012 May;60:20-2.


Prognosis and treatment of patients with acute alcoholic hepatitis.

Papastergiou V, Burroughs AK, Tsochatzis EA.

Expert Rev Gastroenterol Hepatol. 2014 Jul;8(5):471-86. doi: 10.1586/17474124.2014.903800. Epub 2014 Apr 10. Review.


Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.

Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O.

Gastroenterology. 2000 Dec;119(6):1637-48.


Pentoxifylline for alcoholic hepatitis.

Whitfield K, Rambaldi A, Wetterslev J, Gluud C.

Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007339. doi: 10.1002/14651858.CD007339.pub2. Review.


Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis.

Parker R, Armstrong MJ, Corbett C, Rowe IA, Houlihan DD.

Aliment Pharmacol Ther. 2013 May;37(9):845-54. doi: 10.1111/apt.12279. Epub 2013 Mar 13. Review.


The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.

Ball S, Vickery J, Hobart J, Wright D, Green C, Shearer J, Nunn A, Cano MG, MacManus D, Miller D, Mallik S, Zajicek J.

Health Technol Assess. 2015 Feb;19(12):vii-viii, xxv-xxxi, 1-187. doi: 10.3310/hta19120.


Update on the management of alcoholic steatohepatitis.

Stickel F, Seitz HK.

J Gastrointestin Liver Dis. 2013 Jun;22(2):189-97. Review.


Review article: the diagnosis and management of alcoholic hepatitis.

Cohen SM, Ahn J.

Aliment Pharmacol Ther. 2009 Jul;30(1):3-13. doi: 10.1111/j.1365-2036.2009.04002.x. Epub 2009 Mar 26. Review.

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