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Chronic high glucose induced INS-1β cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC.

Chen X, Cui Z, Wei S, Hou J, Xie Z, Peng X, Li J, Cai T, Hang H, Yang F.

Proteomics. 2013 Oct;13(20):3030-9. doi: 10.1002/pmic.201200448.


Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

Schvartz D, Couté Y, Brunner Y, Wollheim CB, Sanchez JC.

Mol Cell Proteomics. 2012 Aug;11(8):244-54. doi: 10.1074/mcp.M112.018051. Epub 2012 Mar 16.


Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways.

Tuo Y, Wang D, Li S, Chen C.

Endocrine. 2011 Apr;39(2):128-38. doi: 10.1007/s12020-010-9432-3. Epub 2010 Dec 15.


Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells.

Couté Y, Brunner Y, Schvartz D, Hernandez C, Masselot A, Lisacek F, Wollheim CB, Sanchez JC.

Proteomics. 2010 Jan;10(1):59-71. doi: 10.1002/pmic.200900080.


Dietary copper supplementation restores β-cell function of Cohen diabetic rats: a link between mitochondrial function and glucose-stimulated insulin secretion.

Weksler-Zangen S, Jörns A, Tarsi-Chen L, Vernea F, Aharon-Hananel G, Saada A, Lenzen S, Raz I.

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1023-34. doi: 10.1152/ajpendo.00036.2013. Epub 2013 Mar 19.


The profile of mitochondrial proteins and their phosphorylation signaling network in INS-1 beta cells.

Cui Z, Hou J, Chen X, Li J, Xie Z, Xue P, Cai T, Wu P, Xu T, Yang F.

J Proteome Res. 2010 Jun 4;9(6):2898-908. doi: 10.1021/pr100139z.


Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.

Brun T, Scarcia P, Li N, Gaudet P, Duhamel D, Palmieri F, Maechler P.

PLoS One. 2013 Dec 12;8(12):e82364. doi: 10.1371/journal.pone.0082364. eCollection 2013.


Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose.

Ahmed M, Muhammed SJ, Kessler B, Salehi A.

Islets. 2010 Sep-Oct;2(5):283-92. Epub 2010 Sep 1.


Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.


Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip.

Lin P, Chen L, Li D, Liu J, Yang N, Sun Y, Xu Y, Fu Y, Hou X.

Tohoku J Exp Med. 2009 Jan;217(1):59-65.


Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.

Casimir M, Lasorsa FM, Rubi B, Caille D, Palmieri F, Meda P, Maechler P.

J Biol Chem. 2009 Sep 11;284(37):25004-14. doi: 10.1074/jbc.M109.015495. Epub 2009 Jul 7.


Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

Lablanche S, Cottet-Rousselle C, Lamarche F, Benhamou PY, Halimi S, Leverve X, Fontaine E.

Cell Death Dis. 2011 Mar 24;2:e134. doi: 10.1038/cddis.2011.15.


Epigallocatechin-3-gallate protects pro-inflammatory cytokine induced injuries in insulin-producing cells through the mitochondrial pathway.

Zhang Z, Ding Y, Dai X, Wang J, Li Y.

Eur J Pharmacol. 2011 Nov 16;670(1):311-6. doi: 10.1016/j.ejphar.2011.08.033. Epub 2011 Sep 8.


Metabolomic analysis of pancreatic beta cells following exposure to high glucose.

Wallace M, Whelan H, Brennan L.

Biochim Biophys Acta. 2013 Mar;1830(3):2583-90.


Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin.

Li XL, Chen T, Wong YS, Xu G, Fan RR, Zhao HL, Chan JC.

Int J Biochem Cell Biol. 2011 Apr;43(4):525-34. doi: 10.1016/j.biocel.2010.12.008. Epub 2010 Dec 14.


Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

Park KS, Wiederkehr A, Kirkpatrick C, Mattenberger Y, Martinou JC, Marchetti P, Demaurex N, Wollheim CB.

J Biol Chem. 2008 Nov 28;283(48):33347-56. doi: 10.1074/jbc.M806251200. Epub 2008 Oct 2.


Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

Mármol P, Pardo B, Wiederkehr A, del Arco A, Wollheim CB, Satrústegui J.

J Biol Chem. 2009 Jan 2;284(1):515-24. doi: 10.1074/jbc.M806729200. Epub 2008 Nov 7.


SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J.

PLoS One. 2009 May 25;4(5):e5684. doi: 10.1371/journal.pone.0005684.

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