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Items: 1 to 20 of 94

1.

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis.

Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, Lanza M, Ugolini G, Caselli G, Rovati LC, Visintin M.

Osteoarthritis Cartilage. 2013 Nov;21(11):1807-10. doi: 10.1016/j.joca.2013.08.015. Epub 2013 Aug 15.

2.

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.

Apte SS.

Biochem J. 2016 Jan 1;473(1):e1-4. doi: 10.1042/BJ20151072. Review.

PMID:
26657033
3.

Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice.

Wei W, Clockaerts S, Bastiaansen-Jenniskens YM, Gierman LM, Botter SM, Bierma-Zeinstra SM, Weinans H, Verhaar JA, Kloppenburg M, Zuurmond AM, van Osch GJ.

Osteoarthritis Cartilage. 2014 Feb;22(2):293-301. doi: 10.1016/j.joca.2013.11.009. Epub 2013 Nov 23.

4.

ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes.

Botter SM, Glasson SS, Hopkins B, Clockaerts S, Weinans H, van Leeuwen JP, van Osch GJ.

Osteoarthritis Cartilage. 2009 May;17(5):636-45. doi: 10.1016/j.joca.2008.09.018. Epub 2008 Oct 17.

5.

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.

Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A.

J Orthop Res. 2011 Apr;29(4):516-22. doi: 10.1002/jor.21215. Epub 2010 Oct 26.

6.

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma.

Poulet B, Westerhof TA, Hamilton RW, Shefelbine SJ, Pitsillides AA.

Osteoarthritis Cartilage. 2013 May;21(5):756-63. doi: 10.1016/j.joca.2013.02.652. Epub 2013 Mar 1.

7.

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints.

Yorimitsu M, Nishida K, Shimizu A, Doi H, Miyazawa S, Komiyama T, Nasu Y, Yoshida A, Watanabe S, Ozaki T.

Osteoarthritis Cartilage. 2008 Jul;16(7):764-71. doi: 10.1016/j.joca.2007.11.006. Epub 2008 Jan 7.

8.

Chondrocyte death during murine osteoarthritis.

Mistry D, Oue Y, Chambers MG, Kayser MV, Mason RM.

Osteoarthritis Cartilage. 2004 Feb;12(2):131-41.

9.

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.

Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A.

Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887.

10.

Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.

Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC.

Ann Rheum Dis. 2014 Sep;73(9):1719-27. doi: 10.1136/annrheumdis-2013-203231. Epub 2013 Jul 12.

PMID:
23852692
11.

Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF{alpha} single-chain Fv antibody (ESBA105) designed for local therapeutic use.

Urech DM, Feige U, Ewert S, Schlosser V, Ottiger M, Polzer K, Schett G, Lichtlen P.

Ann Rheum Dis. 2010 Feb;69(2):443-9. doi: 10.1136/ard.2008.105775. Epub 2009 Mar 16.

PMID:
19293161
12.

Local gene delivery of heme oxygenase-1 by adeno-associated virus into osteoarthritic mouse joints exhibiting synovial oxidative stress.

Kyostio-Moore S, Bangari DS, Ewing P, Nambiar B, Berthelette P, Sookdeo C, Hutto E, Moran N, Sullivan J, Matthews GL, Scaria A, Armentano D.

Osteoarthritis Cartilage. 2013 Feb;21(2):358-67. doi: 10.1016/j.joca.2012.11.002. Epub 2012 Nov 11.

13.

Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.

Holt DW, Henderson ML, Stockdale CE, Farrell JT, Kooyman DL, Bridgewater LC, Seegmiller RE.

Osteoarthritis Cartilage. 2012 May;20(5):430-9. doi: 10.1016/j.joca.2011.11.008. Epub 2011 Nov 26.

14.

The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model.

Al Faqeh H, Nor Hamdan BM, Chen HC, Aminuddin BS, Ruszymah BH.

Exp Gerontol. 2012 Jun;47(6):458-64. doi: 10.1016/j.exger.2012.03.018. Epub 2012 Apr 10.

15.

Analysis of early biochemical markers and regulation by tin protoporphyrin IX in a model of spontaneous osteoarthritis.

Braza-Boïls A, Ferrándiz ML, Terencio MC, Alcaraz MJ.

Exp Gerontol. 2012 May;47(5):406-9. doi: 10.1016/j.exger.2012.03.005. Epub 2012 Mar 17.

PMID:
22459696
16.

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

Caramés B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M.

Ann Rheum Dis. 2012 Apr;71(4):575-81. doi: 10.1136/annrheumdis-2011-200557. Epub 2011 Nov 14.

17.

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T.

Arthritis Rheum. 2009 Jul;60(7):2019-27. doi: 10.1002/art.24654.

18.

Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.

Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW.

Ann Rheum Dis. 2015 Jan;74(1):285-93. doi: 10.1136/annrheumdis-2013-203901. Epub 2013 Nov 20.

19.

Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular injection of alginate-chitosan beads dispersed in an hydrogel.

Oprenyeszk F, Chausson M, Maquet V, Dubuc JE, Henrotin Y.

Osteoarthritis Cartilage. 2013 Aug;21(8):1099-107. doi: 10.1016/j.joca.2013.04.017. Epub 2013 May 13.

20.

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.

Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM, Morris EA, Glasson SS.

Arthritis Rheum. 2009 Mar;60(3):840-7. doi: 10.1002/art.24304.

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