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Items: 1 to 20 of 85

1.

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW 2nd, Trimarco B, Iaccarino G.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2415-24. doi: 10.1161/ATVBAHA.113.302262. Epub 2013 Aug 15.

2.

Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of α1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta.

Kandasamy K, Choudhury S, Singh V, Addison MP, Darzi SA, Kasa JK, Thangamalai R, Dash JR, Kumar T, Sultan F, Singh TU, Parida S, Mishra SK.

J Cardiovasc Pharmacol Ther. 2016 Jan;21(1):100-13. doi: 10.1177/1074248415587968. Epub 2015 May 28.

PMID:
26025460
3.

Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension.

Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila-Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C.

Hypertension. 2014 Feb;63(2):369-75. doi: 10.1161/HYPERTENSIONAHA.113.01991. Epub 2013 Nov 4.

4.

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages.

Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW 2nd, Trimarco B, Iaccarino G.

FEBS Lett. 2013 Nov 1;587(21):3487-94. doi: 10.1016/j.febslet.2013.09.002. Epub 2013 Sep 10.

5.

Suppressed G-protein-coupled receptor kinase 2 activity protects female diabetic-mouse aorta against endothelial dysfunction.

Taguchi K, Matsumoto T, Kamata K, Kobayashi T.

Acta Physiol (Oxf). 2013 Jan;207(1):142-55. doi: 10.1111/j.1748-1716.2012.02473.x. Epub 2012 Aug 27.

PMID:
22925038
6.

Rictor in perivascular adipose tissue controls vascular function by regulating inflammatory molecule expression.

Bhattacharya I, Drägert K, Albert V, Contassot E, Damjanovic M, Hagiwara A, Zimmerli L, Humar R, Hall MN, Battegay EJ, Haas E.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2105-11. doi: 10.1161/ATVBAHA.112.301001. Epub 2013 Jul 18. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):e138.

7.

Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric-oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels.

Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y.

J Pharmacol Exp Ther. 2014 May;349(2):199-208. doi: 10.1124/jpet.113.211854. Epub 2014 Feb 25.

8.

Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.

Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW 2nd, Eckhart AD.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1695-704. doi: 10.1152/ajpheart.00564.2008. Epub 2008 Aug 22.

9.

Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.

Woodall BP, Woodall MC, Luongo TS, Grisanti LA, Tilley DG, Elrod JW, Koch WJ.

J Biol Chem. 2016 Oct 14;291(42):21913-21924. Epub 2016 Aug 26.

10.

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.

Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW 2nd, Hardisson D, Mayor F Jr, Penela P.

J Clin Invest. 2013 Nov;123(11):4714-30. doi: 10.1172/JCI67333. Epub 2013 Oct 25.

11.

Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction.

Szántó M, Rutkai I, Hegedus C, Czikora Á, Rózsahegyi M, Kiss B, Virág L, Gergely P, Tóth A, Bai P.

Cardiovasc Res. 2011 Dec 1;92(3):430-8. doi: 10.1093/cvr/cvr246. Epub 2011 Sep 15.

PMID:
21921080
12.

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

Willemen HL, Eijkelkamp N, Wang H, Dantzer R, Dorn GW 2nd, Kelley KW, Heijnen CJ, Kavelaars A.

Pain. 2010 Sep;150(3):550-60. doi: 10.1016/j.pain.2010.06.015. Epub 2010 Jul 6.

13.

Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability.

Panchatcharam M, Salous AK, Brandon J, Miriyala S, Wheeler J, Patil P, Sunkara M, Morris AJ, Escalante-Alcalde D, Smyth SS.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):837-45. doi: 10.1161/ATVBAHA.113.302335. Epub 2014 Feb 6.

14.

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ.

Circ Res. 2008 Aug 15;103(4):413-22. doi: 10.1161/CIRCRESAHA.107.168336. Epub 2008 Jul 17.

15.

Role of endothelial-derived reactive oxygen species and nitric oxide in norepinephrine-induced rat aortic ring contractions.

Srivastava P, Hegde LG, Patnaik GK, Dikshit M.

Pharmacol Res. 1998 Oct;38(4):265-74.

PMID:
9774489
16.

Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice.

Taguchi K, Kobayashi T, Matsumoto T, Kamata K.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H571-83. doi: 10.1152/ajpheart.01189.2010. Epub 2011 May 13.

17.

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.

Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ.

Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6.

18.

Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.

Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):790-800. doi: 10.1161/ATVBAHA.113.303116. Epub 2014 Feb 13.

19.

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2011 Mar;226(3):627-37. doi: 10.1002/jcp.22384.

20.

MicroRNA-124 as a novel treatment for persistent hyperalgesia.

Willemen HL, Huo XJ, Mao-Ying QL, Zijlstra J, Heijnen CJ, Kavelaars A.

J Neuroinflammation. 2012 Jun 25;9:143. doi: 10.1186/1742-2094-9-143.

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