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Items: 1 to 20 of 96


High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G.

Cancer Prev Res (Phila). 2013 Oct;6(10):1064-73. doi: 10.1158/1940-6207.CAPR-13-0065. Epub 2013 Aug 13.


A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.

Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, Ji B, Huang H, Wang H, Fleming JB, Logsdon CD, Cruz-Monserrate Z.

Gastroenterology. 2013 Dec;145(6):1449-58. doi: 10.1053/j.gastro.2013.08.018. Epub 2013 Aug 16.


E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice.

Stark AP, Chang HH, Jung X, Moro A, Hertzer K, Xu M, Schmidt A, Hines OJ, Eibl G.

Surgery. 2015 Dec;158(6):1564-72. doi: 10.1016/j.surg.2015.07.023. Epub 2015 Aug 18.


Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer.

Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G.

Pancreas. 2016 Mar;45(3):458-65. doi: 10.1097/MPA.0000000000000497.


Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer.

Lanza-Jacoby S, Yan G, Radice G, LePhong C, Baliff J, Hess R.

Exp Biol Med (Maywood). 2013 Jul;238(7):787-97. doi: 10.1177/1535370213493727. Epub 2013 Jul 4.


Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.

Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia-Carracedo D, Wang WM, Kuo CY, Chen D, Arking DE, Lowy AM, Hruban RH, Remotti HE, Su GH.

Oncotarget. 2011 Nov;2(11):862-73.


Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G.

Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24.


Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice.

Liao J, Chung YT, Yang AL, Zhang M, Li H, Zhang W, Yan L, Yang GY.

Mol Carcinog. 2013 Sep;52(9):739-50. doi: 10.1002/mc.21916. Epub 2012 Apr 30.


The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.

Shen R, Wang Q, Cheng S, Liu T, Jiang H, Zhu J, Wu Y, Wang L.

Cancer Lett. 2013 Oct 1;339(1):135-43. doi: 10.1016/j.canlet.2013.07.010. Epub 2013 Jul 22.


Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models.

Omar B, Pacini G, Ahrén B.

Nutrients. 2012 Sep 28;4(10):1367-81. doi: 10.3390/nu4101367.


Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.


Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas.

Al Saati T, Clerc P, Hanoun N, Peuget S, Lulka H, Gigoux V, Capilla F, Béluchon B, Couvelard A, Selves J, Buscail L, Carrier A, Dusetti N, Dufresne M.

Am J Pathol. 2013 Jun;182(6):1996-2004. doi: 10.1016/j.ajpath.2013.02.034. Epub 2013 Apr 8.


Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.

Z'graggen K, Warshaw AL, Werner J, Graeme-Cook F, Jimenez RE, Fernández-Del Castillo C.

Ann Surg. 2001 May;233(5):688-95.


Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.

Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF.

Cancer Res. 2006 Jan 1;66(1):242-7.


IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.

Garcia MN, Grasso D, Lopez-Millan MB, Hamidi T, Loncle C, Tomasini R, Lomberk G, Porteu F, Urrutia R, Iovanna JL.

J Clin Invest. 2014 Nov;124(11):4709-22. doi: 10.1172/JCI76037. Epub 2014 Sep 24.


Obesity, but not high-fat diet, promotes murine pancreatic cancer growth.

White PB, Ziegler KM, Swartz-Basile DA, Wang SS, Lillemoe KD, Pitt HA, Zyromski NJ.

J Gastrointest Surg. 2012 Sep;16(9):1680-5. doi: 10.1007/s11605-012-1931-5. Epub 2012 Jun 12.


Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia.

Lashinger LM, Malone LM, McArthur MJ, Goldberg JA, Daniels EA, Pavone A, Colby JK, Smith NC, Perkins SN, Fischer SM, Hursting SD.

Cancer Prev Res (Phila). 2011 Jul;4(7):1030-40. doi: 10.1158/1940-6207.CAPR-11-0027. Epub 2011 May 18.


Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.


Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets.

Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Milovanovic MZ, Nikolic IG, Zdravkovic NS, Djukic AL, Arsenijevic NN, Lukic ML.

Diabetes. 2013 Jun;62(6):1932-44. doi: 10.2337/db12-0222. Epub 2013 Jan 24.

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