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Reduced EGFR level potentially mediates the Aβ42-induced neuronal loss in transgenic fruit fly and mouse.

Wang L, Liang B, Zhong Y.

Protein Cell. 2013 Sep;4(9):647-9. doi: 10.1007/s13238-013-3043-8. No abstract available.


Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.

Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, Zhong Y.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16743-8. doi: 10.1073/pnas.1208011109. Epub 2012 Sep 27.


Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.

Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, Engelman JA.

J Clin Invest. 2008 Jul;118(7):2609-19. doi: 10.1172/JCI34588.


An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.

Amador ML, Oppenheimer D, Perea S, Maitra A, Cusatis G, Iacobuzio-Donahue C, Baker SD, Ashfaq R, Takimoto C, Forastiere A, Hidalgo M.

Cancer Res. 2004 Dec 15;64(24):9139-43. Erratum in: Cancer Res. 2007 Aug 15;67(16):7937. Cusati, George [corrected to Cusatis, George].


Epidermal growth factor receptor inhibitors in oncology.

Vivanco I, Mellinghoff IK.

Curr Opin Oncol. 2010 Nov;22(6):573-8. doi: 10.1097/CCO.0b013e32833edbdf. Review.


A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.

Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA.

Gastroenterology. 2012 Sep;143(3):730-40. doi: 10.1053/j.gastro.2012.05.034. Epub 2012 May 26.


The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment.

Ostapchenko VG, Chen M, Guzman MS, Xie YF, Lavine N, Fan J, Beraldo FH, Martyn AC, Belrose JC, Mori Y, MacDonald JF, Prado VF, Prado MA, Jackson MF.

J Neurosci. 2015 Nov 11;35(45):15157-69. doi: 10.1523/JNEUROSCI.4081-14.2015.


Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada-Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A.

J Biol Chem. 2012 Jun 29;287(27):23024-33. doi: 10.1074/jbc.M112.367011. Epub 2012 May 4.


AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.

Xie H, Lin L, Tong L, Jiang Y, Zheng M, Chen Z, Jiang X, Zhang X, Ren X, Qu W, Yang Y, Wan H, Chen Y, Zuo J, Jiang H, Geng M, Ding J.

PLoS One. 2011;6(7):e21487. doi: 10.1371/journal.pone.0021487. Epub 2011 Jul 18.


Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells.

Joiakim A, Mathieu PA, Shelp C, Boerner J, Reiners JJ Jr.

Drug Metab Dispos. 2016 May;44(5):665-71. doi: 10.1124/dmd.115.066274. Epub 2016 Mar 7.


Epidermal growth factor receptor (EGFR) signaling and covalent EGFR inhibition in lung cancer.

Heuckmann JM, Rauh D, Thomas RK.

J Clin Oncol. 2012 Sep 20;30(27):3417-20. doi: 10.1200/JCO.2012.43.1825. Epub 2012 Aug 20. No abstract available.


Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.

Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S.

Clin Cancer Res. 2009 Nov 1;15(21):6630-8. doi: 10.1158/1078-0432.CCR-09-1001. Epub 2009 Oct 20.


Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.

Chu J, Li JG, Praticò D.

PLoS One. 2013 Aug 7;8(8):e70991. doi: 10.1371/journal.pone.0070991. eCollection 2013.


[Mechanism and anti-therapy strategy of EGFR-TKI resistance].

Song Y, Yao Y.

Zhonghua Yi Xue Za Zhi. 2014 Aug 13;94(30):2324-6. Chinese. No abstract available.


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