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Items: 1 to 20 of 139

1.

The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.

Chen J, Jiang CS, Ma WQ, Gao LX, Gong JX, Li JY, Li J, Guo YW.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5061-5. doi: 10.1016/j.bmcl.2013.07.039. Epub 2013 Jul 25.

PMID:
23942421
2.

Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.

Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Joharapurkar A, Dhanesha N, Shaikh M, Sairam KV, Kapadnis P.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1111-7. doi: 10.1016/j.bmcl.2011.11.122. Epub 2011 Dec 6.

PMID:
22189136
3.

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

Qiu WW, Shen Q, Yang F, Wang B, Zou H, Li JY, Li J, Tang J.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. doi: 10.1016/j.bmcl.2009.10.017. Epub 2009 Oct 8.

PMID:
19846303
4.

Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.

Dai HL, Gao LX, Yang Y, Li JY, Cheng JG, Li J, Wen R, Peng YQ, Zheng JB.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7440-3. doi: 10.1016/j.bmcl.2012.10.054. Epub 2012 Oct 17.

PMID:
23122522
5.

Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.

Chen J, Gao LX, Gong JX, Jiang CS, Yao LG, Li JY, Li J, Xiao W, Guo YW.

Bioorg Med Chem Lett. 2015;25(10):2211-6. doi: 10.1016/j.bmcl.2015.03.060. Epub 2015 Mar 27.

PMID:
25872983
6.

Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.

Liu QC, Guo TT, Zhang L, Yu Y, Wang P, Yang JF, Li YX.

Eur J Med Chem. 2013 May;63:511-22. doi: 10.1016/j.ejmech.2013.03.001. Epub 2013 Mar 14.

PMID:
23531458
7.

Peptidomimetics as potent and selective PTP1B inhibitors.

Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Shah K, Joharapurkar A, Shaikh M, Sairam KV.

Med Chem. 2013 Aug;9(5):660-71.

PMID:
23030658
8.

Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.

Sasaki T, Li W, Higai K, Koike K.

Bioorg Med Chem Lett. 2015 May 1;25(9):1979-81. doi: 10.1016/j.bmcl.2015.03.014. Epub 2015 Mar 14.

PMID:
25819098
9.

Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.

Liu Q, Guo T, Li D, Li F, Li W.

Eur J Med Chem. 2014 May 22;79:34-46. doi: 10.1016/j.ejmech.2014.03.080. Epub 2014 Mar 29.

PMID:
24721313
10.

1H-2,3-dihydroperimidine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.

Wang WL, Yang DL, Gao LX, Tang CL, Ma WP, Ye HH, Zhang SQ, Zhao YN, Xu HJ, Hu Z, Chen X, Fan WH, Chen HJ, Li JY, Nan FJ, Li J, Feng B.

Molecules. 2013 Dec 23;19(1):102-21. doi: 10.3390/molecules19010102.

11.

Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.

Wang Z, Liu Z, Lee W, Kim SN, Yoon G, Cheon SH.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3337-40. doi: 10.1016/j.bmcl.2014.05.099. Epub 2014 Jun 6.

PMID:
24953600
12.

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.

Sun LP, Ma WP, Gao LX, Yang LL, Quan YC, Li J, Piao HR.

J Enzyme Inhib Med Chem. 2013 Dec;28(6):1199-204. doi: 10.3109/14756366.2012.723206. Epub 2012 Sep 26.

PMID:
23009604
13.

Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.

Wang WL, Huang C, Gao LX, Tang CL, Wang JQ, Wu MC, Sheng L, Chen HJ, Nan FJ, Li JY, Li J, Feng B.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1889-94. doi: 10.1016/j.bmcl.2014.03.015. Epub 2014 Mar 15.

PMID:
24684845
14.

In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B.

Adisakwattana S, Pongsuwan J, Wungcharoen C, Yibchok-anun S.

J Enzyme Inhib Med Chem. 2013 Oct;28(5):1067-72. doi: 10.3109/14756366.2012.715286. Epub 2012 Sep 7.

PMID:
22957721
15.

Design, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors.

Liu J, Deng X, Jin Y, Xu B, Liu W, Jiang F, Fu L.

Pharmazie. 2015 Jul;70(7):446-51.

PMID:
26373204
16.

Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.

Tang YB, Lu D, Chen Z, Hu C, Yang Y, Tian JY, Ye F, Wu L, Zhang ZY, Xiao Z.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2313-8. doi: 10.1016/j.bmcl.2013.02.073. Epub 2013 Feb 26.

PMID:
23499238
17.

Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

He HB, Gao LX, Deng QF, Ma WP, Tang CL, Qiu WW, Tang J, Li JY, Li J, Yang F.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7237-42. doi: 10.1016/j.bmcl.2012.09.040. Epub 2012 Sep 21.

PMID:
23067554
18.

Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.

Ye D, Zhang Y, Wang F, Zheng M, Zhang X, Luo X, Shen X, Jiang H, Liu H.

Bioorg Med Chem. 2010 Mar 1;18(5):1773-82. doi: 10.1016/j.bmc.2010.01.055. Epub 2010 Jan 28.

PMID:
20153651
19.

Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.

Zhang L, Jiang CS, Gao LX, Gong JX, Wang ZH, Li JY, Li J, Li XW, Guo YW.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):778-781. doi: 10.1016/j.bmcl.2015.12.097. Epub 2015 Dec 29.

PMID:
26774579
20.

[Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors].

Du X, Zhang SE, Liu JZ, Nie FL, Ye F, Tian JY, Xiao ZY.

Yao Xue Xue Bao. 2012 Mar;47(3):367-73. Chinese.

PMID:
22645761

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