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Items: 1 to 20 of 109

1.

Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA).

Migawa MT, Prakash TP, Vasquez G, Seth PP, Swayze EE.

Org Lett. 2013 Sep 6;15(17):4316-9. doi: 10.1021/ol401730d. Epub 2013 Aug 13.

PMID:
23937264
2.

Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides.

Kozlov IA, Zielinski M, Allart B, Kerremans L, Van Aerschot A, Busson R, Herdewijn P, Orgel LE.

Chemistry. 2000 Jan;6(1):151-5.

PMID:
10747399
3.

Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.

Seth PP, Yu J, Jazayeri A, Pallan PS, Allerson CR, Østergaard ME, Liu F, Herdewijn P, Egli M, Swayze EE.

J Org Chem. 2012 Jun 1;77(11):5074-85. doi: 10.1021/jo300594b. Epub 2012 May 18.

4.

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP.

J Am Chem Soc. 2011 Oct 19;133(41):16642-9. doi: 10.1021/ja207086x. Epub 2011 Sep 22.

5.

Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.

Zhou C, Plashkevych O, Chattopadhyaya J.

J Org Chem. 2009 May 1;74(9):3248-65. doi: 10.1021/jo900391n.

PMID:
19348480
6.

Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.

Li Q, Yuan F, Zhou C, Plashkevych O, Chattopadhyaya J.

J Org Chem. 2010 Sep 17;75(18):6122-40. doi: 10.1021/jo100900v.

PMID:
20738147
8.

Solution structure of a HNA-RNA hybrid.

Lescrinier E, Esnouf R, Schraml J, Busson R, Heus H, Hilbers C, Herdewijn P.

Chem Biol. 2000 Sep;7(9):719-31.

9.

Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners.

Van Aerschot A, Meldgaard M, Schepers G, Volders F, Rozenski J, Busson R, Herdewijn P.

Nucleic Acids Res. 2001 Oct 15;29(20):4187-94.

10.

Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.

Kozlov IA, De Bouvere B, Van Aerschot A, Herdewijn P, Orgel LE.

J Am Chem Soc. 1999;121(25):5856-9.

PMID:
11542282
11.

Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.

Wang J, Verbeure B, Luyten I, Froeyen M, Hendrix C, Rosemeyer H, Seela F, Van Aerschot A, Herdewijn P.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):785-8.

PMID:
11563116
12.

Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M.

Biochemistry. 2012 Jan 10;51(1):7-9. doi: 10.1021/bi201810r. Epub 2011 Dec 29.

13.

Structural characteristics of 2'-O-(2-methoxyethyl)-modified nucleic acids from molecular dynamics simulations.

Lind KE, Mohan V, Manoharan M, Ferguson DM.

Nucleic Acids Res. 1998 Aug 15;26(16):3694-799.

14.

Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.

Zhou C, Liu Y, Andaloussi M, Badgujar N, Plashkevych O, Chattopadhyaya J.

J Org Chem. 2009 Jan 2;74(1):118-34. doi: 10.1021/jo8016742.

PMID:
19055352
15.

Effect of LNA modifications on small molecule binding to nucleic acids.

Marin V, Hansen HF, Koch T, Armitage BA.

J Biomol Struct Dyn. 2004 Jun;21(6):841-50.

PMID:
15107006
16.

Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure.

Kozlov IA, Politis PK, Van Aerschot A, Busson R, Herdewijn P, Orgel LE.

J Am Chem Soc. 1999 Mar 31;121(12):2653-6.

PMID:
11543583
17.

Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA).

Gu P, Schepers G, Griebel C, Rozenski J, Gais HJ, Herdewijn P, Van Aerschot A.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):993-8.

PMID:
16248079
20.

Hybridisation potential of 1',3'-Di-O-methylaltropyranoside nucleic acids.

Venkatesham A, Kachare D, Schepers G, Rozenski J, Froeyen M, Van Aerschot A.

Molecules. 2015 Mar 3;20(3):4020-41. doi: 10.3390/molecules20034020.

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