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Items: 1 to 20 of 97

1.

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.

Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, Fabregat I, Sánchez A, Inman GJ.

PLoS One. 2013 Jul 23;8(7):e69535. doi: 10.1371/journal.pone.0069535. Print 2013.

2.

BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.

García-Álvaro M, Addante A, Roncero C, Fernández M, Fabregat I, Sánchez A, Herrera B.

Int J Mol Sci. 2015 Aug 28;16(9):20431-48. doi: 10.3390/ijms160920431.

3.

Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases.

Herrera B, Dooley S, Breitkopf-Heinlein K.

Int J Mol Sci. 2014 Mar 25;15(4):5199-220. doi: 10.3390/ijms15045199. Review.

4.

Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation.

Herrera B, van Dinther M, Ten Dijke P, Inman GJ.

Cancer Res. 2009 Dec 15;69(24):9254-62. doi: 10.1158/0008-5472.CAN-09-2912.

5.

TGF-β signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells.

Mu X, Lin S, Yang J, Chen C, Chen Y, Herzig MC, Washburn K, Halff GA, Walter CA, Sun B, Sun LZ.

PLoS One. 2013 May 21;8(5):e63436. doi: 10.1371/journal.pone.0063436. Print 2013.

6.

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.

Upton PD, Davies RJ, Trembath RC, Morrell NW.

J Biol Chem. 2009 Jun 5;284(23):15794-804. doi: 10.1074/jbc.M109.002881. Epub 2009 Apr 14.

7.

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Mitrofan CG, Appleby SL, Nash GB, Mallat Z, Chilvers ER, Upton PD, Morrell NW.

J Biol Chem. 2017 Aug 18;292(33):13714-13726. doi: 10.1074/jbc.M117.778506. Epub 2017 Jun 23.

8.

Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains.

Kienast Y, Jucknischke U, Scheiblich S, Thier M, de Wouters M, Haas A, Lehmann C, Brand V, Bernicke D, Honold K, Lorenz S.

J Biol Chem. 2016 Feb 12;291(7):3395-410. doi: 10.1074/jbc.M115.680009. Epub 2015 Dec 16.

9.

Bone morphogenetic protein 9 overexpression reduces osteosarcoma cell migration and invasion.

Lv Z, Yang D, Li J, Hu M, Luo M, Zhan X, Song P, Liu C, Bai H, Li B, Yang Y, Chen Y, Shi Q, Weng Y.

Mol Cells. 2013 Aug;36(2):119-26. doi: 10.1007/s10059-013-0043-8. Epub 2013 Jun 25.

10.

Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway.

Wang Y, Wu J, Lin B, Li X, Zhang H, Ding H, Chen X, Lan L, Luo H.

Toxicology. 2014 Dec 4;326:9-17. doi: 10.1016/j.tox.2014.09.010. Epub 2014 Sep 28.

PMID:
25268046
11.

Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, Ucran JA, Liharska K, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2012 Aug 10;287(33):27313-25. doi: 10.1074/jbc.M112.377960. Epub 2012 Jun 20.

12.

BMP activated Smad signaling strongly promotes migration and invasion of hepatocellular carcinoma cells.

Maegdefrau U, Bosserhoff AK.

Exp Mol Pathol. 2012 Feb;92(1):74-81. doi: 10.1016/j.yexmp.2011.10.004. Epub 2011 Oct 15.

PMID:
22024355
13.

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.

Rostama B, Turner JE, Seavey GT, Norton CR, Gridley T, Vary CP, Liaw L.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2626-37. doi: 10.1161/ATVBAHA.115.306541. Epub 2015 Oct 15.

14.

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

Fernando J, Sancho P, Fernández-Rodriguez CM, Lledó JL, Caja L, Campbell JS, Fausto N, Fabregat I.

J Cell Physiol. 2012 Apr;227(4):1319-25. doi: 10.1002/jcp.22843.

15.

All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways.

Liu Y, Liu Y, Zhang R, Wang X, Huang F, Yan Z, Nie M, Huang J, Wang Y, Wang Y, Chen L, Yin L, He B, Deng Z.

Int J Biochem Cell Biol. 2014 Feb;47:47-56. doi: 10.1016/j.biocel.2013.11.018. Epub 2013 Dec 1.

PMID:
24300824
16.

Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.

Wei Z, Salmon RM, Upton PD, Morrell NW, Li W.

J Biol Chem. 2014 Nov 7;289(45):31150-9. doi: 10.1074/jbc.M114.579771. Epub 2014 Sep 18.

17.

Regulation of the ALK1 ligands, BMP9 and BMP10.

Li W, Salmon RM, Jiang H, Morrell NW.

Biochem Soc Trans. 2016 Aug 15;44(4):1135-41. doi: 10.1042/BST20160083. Review.

PMID:
27528761
18.

WSS25 inhibits growth of xenografted hepatocellular cancer cells in nude mice by disrupting angiogenesis via blocking bone morphogenetic protein (BMP)/Smad/Id1 signaling.

Qiu H, Yang B, Pei ZC, Zhang Z, Ding K.

J Biol Chem. 2010 Oct 15;285(42):32638-46. doi: 10.1074/jbc.M110.105544. Epub 2010 Aug 2.

19.

Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines.

Baiz D, Dapas B, Farra R, Scaggiante B, Pozzato G, Zanconati F, Fiotti N, Consoloni L, Chiaretti S, Grassi G.

World J Gastroenterol. 2014 Jan 21;20(3):795-803. doi: 10.3748/wjg.v20.i3.795.

20.

Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.

Chen B, Wei W, Ma L, Yang B, Gill RM, Chua MS, Butte AJ, So S.

Gastroenterology. 2017 Jun;152(8):2022-2036. doi: 10.1053/j.gastro.2017.02.039. Epub 2017 Mar 8.

PMID:
28284560

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