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Items: 1 to 20 of 126

1.

RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation.

Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS.

PLoS One. 2013 Jul 23;8(7):e69315. doi: 10.1371/journal.pone.0069315. Print 2013.

2.

Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition.

Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE Jr, Vitale M.

Blood. 2013 Aug 15;122(7):1305-11. doi: 10.1182/blood-2013-04-490599. Epub 2013 Jul 9.

3.

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.

Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K.

Blood. 2008 Jan 15;111(2):596-604. Epub 2007 Oct 9.

4.

FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.

Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H.

Blood. 2011 Aug 25;118(8):2285-95. doi: 10.1182/blood-2011-04-348482. Epub 2011 Jun 7.

5.

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B.

Blood. 2012 Jan 26;119(4):1054-63. doi: 10.1182/blood-2011-08-372193. Epub 2011 Nov 1.

6.
7.

PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice.

Williams CM, Harper MT, Poole AW.

Platelets. 2014;25(1):62-8. doi: 10.3109/09537104.2012.761686. Epub 2013 Feb 12.

PMID:
23402219
8.

Proteasome function is required for platelet production.

Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS.

J Clin Invest. 2014 Sep;124(9):3757-66. doi: 10.1172/JCI75247. Epub 2014 Jul 25.

9.

Sustained thrombocytopenia in mice: serial studies of megakaryocytes and platelets.

Stenberg PE, Levin J, Corash L.

Exp Hematol. 1990 Feb;18(2):124-32.

PMID:
2303104
10.

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Mazharian A, Mori J, Wang YJ, Heising S, Neel BG, Watson SP, Senis YA.

Blood. 2013 May 16;121(20):4205-20. doi: 10.1182/blood-2012-08-449272. Epub 2013 Mar 18.

11.

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J.

Blood. 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30.

12.

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.

Chen Y, Aardema J, Kale S, Whichard ZL, Awomolo A, Blanchard E, Chang B, Myers DR, Ju L, Tran R, Reece D, Christensen H, Boukour S, Debili N, Strom TS, Rawlings D, Vázquez FX, Voth GA, Zhu C, Kahr WH, Lam WA, Corey SJ.

Blood. 2013 Sep 5;122(10):1695-706. doi: 10.1182/blood-2013-03-484550. Epub 2013 Jul 23.

13.

Immune thrombocytopenia: antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro.

Iraqi M, Perdomo J, Yan F, Choi PY, Chong BH.

Haematologica. 2015 May;100(5):623-32. doi: 10.3324/haematol.2014.115634. Epub 2015 Feb 14.

14.

Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.

Kostyak JC, Naik MU, Naik UP.

Blood. 2012 Jan 19;119(3):838-46. doi: 10.1182/blood-2011-04-346098. Epub 2011 Nov 29.

15.

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.

Machlus KR, Thon JN, Italiano JE Jr.

Br J Haematol. 2014 Apr;165(2):227-36. doi: 10.1111/bjh.12758. Epub 2014 Feb 6. Review.

PMID:
24499183
16.

Neuraminidase-induced thrombocytopenia in mice: effects on thrombopoiesis.

Stenberg PE, Levin J, Baker G, Mok Y, Corash L.

J Cell Physiol. 1991 Apr;147(1):7-16.

PMID:
2037624
17.
18.

OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.

Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y.

PLoS One. 2013;8(3):e58123. doi: 10.1371/journal.pone.0058123. Epub 2013 Mar 1.

19.

Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation.

Novak EK, Reddington M, Zhen L, Stenberg PE, Jackson CW, McGarry MP, Swank RT.

Blood. 1995 Apr 1;85(7):1781-9.

20.

Serum response factor is an essential transcription factor in megakaryocytic maturation.

Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS.

Blood. 2010 Sep 16;116(11):1942-50. doi: 10.1182/blood-2010-01-261743. Epub 2010 Jun 4.

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