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Items: 1 to 20 of 103

1.

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.

Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP.

J Leukoc Biol. 2013 Dec;94(6):1243-51. doi: 10.1189/jlb.0213097. Epub 2013 Aug 9.

2.

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling.

Balabanian K, Levoye A, Klemm L, Lagane B, Hermine O, Harriague J, Baleux F, Arenzana-Seisdedos F, Bachelerie F.

J Clin Invest. 2008 Mar;118(3):1074-84. doi: 10.1172/JCI33187.

3.

CXCL12/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome.

Bachelerie F.

Dis Markers. 2010;29(3-4):189-98. doi: 10.3233/DMA-2010-0736. Review.

4.

Clinical and genetic features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) syndrome.

Dotta L, Tassone L, Badolato R.

Curr Mol Med. 2011 Jun;11(4):317-25. Review.

PMID:
21506920
5.

Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.

McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G.

PLoS One. 2009 Dec 1;4(12):e8102. doi: 10.1371/journal.pone.0008102.

6.

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.

Balabanian K, Lagane B, Pablos JL, Laurent L, Planchenault T, Verola O, Lebbe C, Kerob D, Dupuy A, Hermine O, Nicolas JF, Latger-Cannard V, Bensoussan D, Bordigoni P, Baleux F, Le Deist F, Virelizier JL, Arenzana-Seisdedos F, Bachelerie F.

Blood. 2005 Mar 15;105(6):2449-57. Epub 2004 Nov 9.

7.

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.

Lagane B, Chow KY, Balabanian K, Levoye A, Harriague J, Planchenault T, Baleux F, Gunera-Saad N, Arenzana-Seisdedos F, Bachelerie F.

Blood. 2008 Jul 1;112(1):34-44. doi: 10.1182/blood-2007-07-102103. Epub 2008 Apr 24.

8.

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

Mueller W, Schütz D, Nagel F, Schulz S, Stumm R.

PLoS One. 2013 May 29;8(5):e64975. doi: 10.1371/journal.pone.0064975. Print 2013.

9.

WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.

Kawai T, Choi U, Cardwell L, DeRavin SS, Naumann N, Whiting-Theobald NL, Linton GF, Moon J, Murphy PM, Malech HL.

Blood. 2007 Jan 1;109(1):78-84. Epub 2006 Aug 31.

10.

Stromal-derived factor-1 abolishes constitutive apoptosis of WHIM syndrome neutrophils harbouring a truncating CXCR4 mutation.

Sanmun D, Garwicz D, Smith CI, Palmblad J, Fadeel B.

Br J Haematol. 2006 Sep;134(6):640-4. Epub 2006 Aug 9.

PMID:
16899028
11.

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.

Walters KB, Green JM, Surfus JC, Yoo SK, Huttenlocher A.

Blood. 2010 Oct 14;116(15):2803-11. doi: 10.1182/blood-2010-03-276972. Epub 2010 Jun 30.

12.

Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients.

Tassone L, Moratto D, Vermi W, De Francesco M, Notarangelo LD, Porta F, Lougaris V, Facchetti F, Plebani A, Badolato R.

Blood. 2010 Dec 2;116(23):4870-3. doi: 10.1182/blood-2010-03-272096. Epub 2010 Aug 24.

13.

The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse.

Kallikourdis M, Trovato AE, Anselmi F, Sarukhan A, Roselli G, Tassone L, Badolato R, Viola A.

Blood. 2013 Aug 1;122(5):666-73. doi: 10.1182/blood-2012-10-461830. Epub 2013 Jun 21.

14.

Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors.

Gómez-Moutón C, Fischer T, Peregil RM, Jiménez-Baranda S, Stossel TP, Nakamura F, Mañes S.

Blood. 2015 Feb 12;125(7):1116-25. doi: 10.1182/blood-2014-09-601807. Epub 2014 Oct 29.

15.

Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome.

Gulino AV, Moratto D, Sozzani S, Cavadini P, Otero K, Tassone L, Imberti L, Pirovano S, Notarangelo LD, Soresina R, Mazzolari E, Nelson DL, Notarangelo LD, Badolato R.

Blood. 2004 Jul 15;104(2):444-52. Epub 2004 Mar 16.

16.

WHIM syndrome: congenital immune deficiency disease.

Kawai T, Malech HL.

Curr Opin Hematol. 2009 Jan;16(1):20-6. doi: 10.1097/MOH.0b013e32831ac557. Review.

17.

[CXCR4, a therapeutic target in rare immunodeficiencies?].

Bignon A, Biajoux V, Bouchet-Delbos L, Emilie D, Lortholary O, Balabanian K.

Med Sci (Paris). 2011 Apr;27(4):391-7. doi: 10.1051/medsci/2011274015. Epub 2011 Apr 28. Review. French.

18.

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.

Balabanian K, Brotin E, Biajoux V, Bouchet-Delbos L, Lainey E, Fenneteau O, Bonnet D, Fiette L, Emilie D, Bachelerie F.

Blood. 2012 Jun 14;119(24):5722-30. doi: 10.1182/blood-2012-01-403378. Epub 2012 Mar 20.

19.

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.

Liu Q, Chen H, Ojode T, Gao X, Anaya-O'Brien S, Turner NA, Ulrick J, DeCastro R, Kelly C, Cardones AR, Gold SH, Hwang EI, Wechsler DS, Malech HL, Murphy PM, McDermott DH.

Blood. 2012 Jul 5;120(1):181-9. doi: 10.1182/blood-2011-12-395608. Epub 2012 May 17.

20.

[Dysfunctions of the CXCL12 (SDF-1)/CXCR4 signaling axis in the WHIM syndrome and the idiopathic CD4(+) T-cell lymphocytopenia].

Biajoux V, Bignon A, Bouchet-Delbos L, Emilie D, Balabanian K.

Biol Aujourdhui. 2010;204(4):273-84. doi: 10.1051/jbio/2010022. Epub 2011 Jan 10. Review. French.

PMID:
21215244

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