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Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

Bharti SK, Sommers JA, George F, Kuper J, Hamon F, Shin-ya K, Teulade-Fichou MP, Kisker C, Brosh RM Jr.

J Biol Chem. 2013 Sep 27;288(39):28217-29. doi: 10.1074/jbc.M113.496463. Epub 2013 Aug 9.


FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.

Wu Y, Shin-ya K, Brosh RM Jr.

Mol Cell Biol. 2008 Jun;28(12):4116-28. doi: 10.1128/MCB.02210-07. Epub 2008 Apr 21.


Biochemical characterization of Warsaw breakage syndrome helicase.

Wu Y, Sommers JA, Khan I, de Winter JP, Brosh RM Jr.

J Biol Chem. 2012 Jan 6;287(2):1007-21. doi: 10.1074/jbc.M111.276022. Epub 2011 Nov 18.


G-quadruplex recognition and remodeling by the FANCJ helicase.

Wu CG, Spies M.

Nucleic Acids Res. 2016 Oct 14;44(18):8742-8753. Epub 2016 Jun 24.


The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.

Rudolf J, Makrantoni V, Ingledew WJ, Stark MJ, White MF.

Mol Cell. 2006 Sep 15;23(6):801-8.


A distinct triplex DNA unwinding activity of ChlR1 helicase.

Guo M, Hundseth K, Ding H, Vidhyasagar V, Inoue A, Nguyen CH, Zain R, Lee JS, Wu Y.

J Biol Chem. 2015 Feb 20;290(8):5174-89. doi: 10.1074/jbc.M114.634923. Epub 2015 Jan 5.


FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.

Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr.

J Biol Chem. 2009 Jul 3;284(27):18458-70. doi: 10.1074/jbc.M109.012229. Epub 2009 May 5.


Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.

Wu Y, Sommers JA, Suhasini AN, Leonard T, Deakyne JS, Mazin AV, Shin-Ya K, Kitao H, Brosh RM Jr.

Blood. 2010 Nov 11;116(19):3780-91. doi: 10.1182/blood-2009-11-256016. Epub 2010 Jul 16.


Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.

Wu Y, Suhasini AN, Brosh RM Jr.

Cell Mol Life Sci. 2009 Apr;66(7):1209-22. doi: 10.1007/s00018-008-8580-6. Review.


FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.

London TB, Barber LJ, Mosedale G, Kelly GP, Balasubramanian S, Hickson ID, Boulton SJ, Hiom K.

J Biol Chem. 2008 Dec 26;283(52):36132-9. doi: 10.1074/jbc.M808152200. Epub 2008 Oct 31.


G-quadruplexes and helicases.

Mendoza O, Bourdoncle A, Boulé JB, Brosh RM Jr, Mergny JL.

Nucleic Acids Res. 2016 Mar 18;44(5):1989-2006. doi: 10.1093/nar/gkw079. Epub 2016 Feb 15. Review.


Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.

Guo M, Vidhyasagar V, Ding H, Wu Y.

J Biol Chem. 2014 Apr 11;289(15):10551-65. doi: 10.1074/jbc.M113.538892. Epub 2014 Feb 25.


FANCJ promotes DNA synthesis through G-quadruplex structures.

Castillo Bosch P, Segura-Bayona S, Koole W, van Heteren JT, Dewar JM, Tijsterman M, Knipscheer P.

EMBO J. 2014 Nov 3;33(21):2521-33. doi: 10.15252/embj.201488663. Epub 2014 Sep 5.


Genomic stability: FANCJ-dependent G4 DNA repair.

Maizels N.

Curr Biol. 2008 Jul 22;18(14):R613-4. doi: 10.1016/j.cub.2008.06.011.


Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.

Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM Jr.

EMBO J. 2011 Feb 16;30(4):692-705. doi: 10.1038/emboj.2010.362. Epub 2011 Jan 14.


Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.

Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr.

J Biol Chem. 2014 Jul 18;289(29):19928-41. doi: 10.1074/jbc.M113.542456. Epub 2014 Jun 3.


Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.

Kruisselbrink E, Guryev V, Brouwer K, Pontier DB, Cuppen E, Tijsterman M.

Curr Biol. 2008 Jun 24;18(12):900-5. doi: 10.1016/j.cub.2008.05.013. Epub 2008 Jun 5.


G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase.

Wallgren M, Mohammad JB, Yan KP, Pourbozorgi-Langroudi P, Ebrahimi M, Sabouri N.

Nucleic Acids Res. 2016 Jul 27;44(13):6213-31. doi: 10.1093/nar/gkw349. Epub 2016 May 16.


Impact of age-associated cyclopurine lesions on DNA repair helicases.

Khan I, Suhasini AN, Banerjee T, Sommers JA, Kaplan DL, Kuper J, Kisker C, Brosh RM Jr.

PLoS One. 2014 Nov 19;9(11):e113293. doi: 10.1371/journal.pone.0113293. eCollection 2014.

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