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Items: 1 to 20 of 101

1.

Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation.

Cona MM, Alpizar YA, Li J, Bauwens M, Feng Y, Sun Z, Zhang J, Chen F, Talavera K, de Witte P, Verbruggen A, Oyen R, Ni Y.

Pharm Res. 2014 Feb;31(2):278-90. doi: 10.1007/s11095-013-1159-4. Epub 2013 Aug 9.

PMID:
23934256
2.

Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations.

Cona MM, Li J, Feng Y, Chen F, Verbruggen A, Witte Pd, Oyen R, Ni Y.

Anticancer Agents Med Chem. 2014;14(6):852-61.

PMID:
24102315
3.

Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction.

Cona MM, Feng Y, Zhang J, Li Y, Verbruggen A, Oyen R, Ni Y.

Drug Deliv. 2015 May;22(3):427-35. doi: 10.3109/10717544.2013.873838. Epub 2014 Jan 13.

PMID:
24417698
4.

Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses.

Li J, Zhang J, Yang S, Jiang C, Zhang D, Jin Q, Wang Q, Wang C, Ni Y, Yin Z, Song S.

Mol Pharm. 2016 Jan 4;13(1):232-40. doi: 10.1021/acs.molpharmaceut.5b00686. Epub 2015 Dec 10.

PMID:
26568406
5.

Evaluation of hypericin: effect of aggregation on targeting biodistribution.

Liu X, Jiang C, Li Y, Liu W, Yao N, Gao M, Ji Y, Huang D, Yin Z, Sun Z, Ni Y, Zhang J.

J Pharm Sci. 2015 Jan;104(1):215-22. doi: 10.1002/jps.24230. Epub 2014 Nov 13.

PMID:
25395358
6.

Biodistribution and radiation dosimetry of radioiodinated hypericin as a cancer therapeutic.

Cona MM, Koole M, Feng Y, Liu Y, Verbruggen A, Oyen R, Ni Y.

Int J Oncol. 2014 Mar;44(3):819-29. doi: 10.3892/ijo.2013.2217. Epub 2013 Dec 17.

PMID:
24366374
7.

Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction.

Cona MM, Feng Y, Li Y, Chen F, Vunckx K, Zhou L, Van Slambrouck K, Rezaei A, Gheysens O, Nuyts J, Verbruggen A, Oyen R, Ni Y.

J Cardiovasc Pharmacol. 2013 Sep;62(3):304-11. doi: 10.1097/FJC.0b013e31829b2c6b.

PMID:
23714775
8.

Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis.

Kong M, Zhang J, Jiang C, Jiang X, Li Y, Gao M, Yao N, Huang D, Wang X, Fang Z, Liu W, Sun Z, Ni Y.

J Drug Target. 2013 Jul;21(6):604-10. doi: 10.3109/1061186X.2013.789034. Epub 2013 Apr 29.

PMID:
23627568
9.

Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.

Zhang D, Jiang C, Yang S, Gao M, Huang D, Wang X, Shao H, Feng Y, Sun Z, Ni Y, Zhang J, Yin Z.

J Drug Target. 2016;24(6):566-77. doi: 10.3109/1061186X.2015.1113541. Epub 2015 Nov 19.

PMID:
26586010
10.

Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models.

Li J, Cona MM, Chen F, Feng Y, Zhou L, Yu J, Nuyts J, de Witte P, Zhang J, Himmelreich U, Verbruggen A, Ni Y.

Theranostics. 2012;2(10):1010-9. doi: 10.7150/thno.4924. Epub 2012 Oct 18.

11.

Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.

Ji Y, Zhan Y, Jiang C, Jiang X, Gao M, Liu W, Li Y, Wang J, Wang Q, Cona MM, Yao N, Wang X, Fang Z, Yin Z, Zhang J, Sun Z, Ni Y.

J Drug Target. 2014 May;22(4):304-12. doi: 10.3109/1061186X.2013.867962. Epub 2013 Dec 13.

PMID:
24328682
12.

Radiopharmaceutical evaluation of (131)I-protohypericin as a necrosis avid compound.

Liu X, Feng Y, Jiang C, Lou B, Li Y, Liu W, Yao N, Gao M, Ji Y, Wang Q, Huang D, Yin Z, Sun Z, Ni Y, Zhang J.

J Drug Target. 2015 Jun;23(5):417-26. doi: 10.3109/1061186X.2014.1002787. Epub 2015 Feb 6.

PMID:
25655506
13.

Improved clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats.

Cona MM, Feng Y, Verbruggen A, Oyen R, Ni Y.

Exp Biol Med (Maywood). 2013 Dec;238(12):1437-49. doi: 10.1177/1535370213508235. Epub 2013 Oct 21.

PMID:
24146264
14.

Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models.

Liu W, Zhang D, Feng Y, Li Y, Huang D, Jiang C, Gao M, Peng F, Wang X, Jing S, Jiang X, Ni Y, Zhang J.

J Drug Target. 2015 May;23(4):371-9. doi: 10.3109/1061186X.2014.1000337. Epub 2015 Jan 9.

PMID:
25572455
15.

Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.

Li J, Cona MM, Chen F, Feng Y, Zhou L, Zhang G, Nuyts J, de Witte P, Zhang J, Yu J, Oyen R, Verbruggen A, Ni Y.

Theranostics. 2013;3(2):127-37. doi: 10.7150/thno.5790. Epub 2013 Feb 13.

16.
17.

Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis.

Qi X, Shao H, Zhang J, Sun Z, Ni Y, Xu K.

Radiol Med. 2015 Feb;120(2):213-21. doi: 10.1007/s11547-014-0433-9. Epub 2014 Jul 11.

PMID:
25012473
18.

A dual-targeting anticancer approach: soil and seed principle.

Li J, Sun Z, Zhang J, Shao H, Cona MM, Wang H, Marysael T, Chen F, Prinsen K, Zhou L, Huang D, Nuyts J, Yu J, Meng B, Bormans G, Fang Z, de Witte P, Li Y, Verbruggen A, Wang X, Mortelmans L, Xu K, Marchal G, Ni Y.

Radiology. 2011 Sep;260(3):799-807. doi: 10.1148/radiol.11102120. Epub 2011 Jun 28.

PMID:
21712473
19.

Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model.

Liu X, Jiang C, Zhang D, Gao M, Peng F, Huang D, Sun Z, Ni Y, Zhang J, Yin Z.

Oncotarget. 2015 Sep 22;6(28):26400-10. doi: 10.18632/oncotarget.4568.

20.

Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.

Marysael T, Bauwens M, Ni Y, Bormans G, Rozenski J, de Witte P.

Invest New Drugs. 2012 Dec;30(6):2132-40. doi: 10.1007/s10637-011-9778-2. Epub 2011 Dec 21.

PMID:
22187204

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