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Items: 1 to 20 of 116

1.

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S.

Neuron. 2013 Aug 7;79(3):447-60. doi: 10.1016/j.neuron.2013.05.035.

2.

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.

Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S.

Nat Neurosci. 2016 Jan;19(1):55-64. doi: 10.1038/nn.4188. Epub 2015 Dec 7.

3.

X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.

Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T.

J Biol Chem. 2008 Dec 19;283(51):35763-71. doi: 10.1074/jbc.M801353200. Epub 2008 Oct 9.

5.

Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein.

Santosa C, Rasche S, Barakat A, Bellingham SA, Ho M, Tan J, Hill AF, Masters CL, McLean C, Evin G.

Neurobiol Dis. 2011 Jul;43(1):176-83. doi: 10.1016/j.nbd.2011.03.009. Epub 2011 Apr 3.

PMID:
21440067
6.

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

Marlow L, Cain M, Pappolla MA, Sambamurti K.

J Mol Neurosci. 2003;20(3):233-9.

PMID:
14501002
7.

Dynamin 1 regulates amyloid generation through modulation of BACE-1.

Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D.

PLoS One. 2012;7(9):e45033. Epub 2012 Sep 14.

8.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.

PMID:
11406613
9.

Retromers in Alzheimer's disease.

Siegenthaler BM, Rajendran L.

Neurodegener Dis. 2012;10(1-4):116-21. doi: 10.1159/000335910. Epub 2012 Mar 3. Review.

10.

BACE (beta-secretase) modulates the processing of APLP2 in vivo.

Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD.

Mol Cell Neurosci. 2004 Apr;25(4):642-9.

PMID:
15080893
11.

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

Prabhu Y, Burgos PV, Schindler C, Farías GG, Magadán JG, Bonifacino JS.

Mol Biol Cell. 2012 Jun;23(12):2339-51. doi: 10.1091/mbc.E11-11-0944. Epub 2012 May 2. Erratum in: Mol Biol Cell. 2012 Jul;23(13):2620.

12.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

13.

BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis.

Marks N, Berg MJ.

Neurochem Res. 2010 Feb;35(2):181-210. doi: 10.1007/s11064-009-0054-1. Epub 2009 Sep 17. Review.

PMID:
19760173
14.

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1630-5. doi: 10.1073/pnas.0908953107. Epub 2009 Dec 28.

15.

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts.

Cheng H, Vetrivel KS, Gong P, Meckler X, Parent A, Thinakaran G.

Nat Clin Pract Neurol. 2007 Jul;3(7):374-82. Review.

16.
17.

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.

Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF.

J Neurochem. 2012 Sep;122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.

18.

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE.

FASEB J. 2007 Sep;21(11):2742-52. Epub 2007 Apr 26.

PMID:
17463224
19.

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE.

J Biol Chem. 2009 May 1;284(18):11863-72. doi: 10.1074/jbc.M807345200. Epub 2009 Feb 27.

20.

Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.

Cuartero Y, Mellado M, Capell A, Alvarez-Dolado M, Verges M.

Traffic. 2012 Oct;13(10):1393-410. doi: 10.1111/j.1600-0854.2012.01392.x. Epub 2012 Jul 25.

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