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Items: 1 to 20 of 96

1.

[Down-regulation of Smoothened gene expression inhibits proliferation of breast cancer stem cells].

Mao J, Fan PH, Ma W, Zhang QQ, Wang B, Fan SJ, Li LH.

Zhonghua Bing Li Xue Za Zhi. 2013 Apr;42(4):262-6. doi: 10.3760/cma.j.issn.0529-5807.2013.04.011. Chinese.

PMID:
23928535
2.

The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.

He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, Zhao H, Zhao L, Jiang Q, Yu Z, Jin F, Mi X, Wang E, Cui Z, Fu L, Chen J, Wei M.

Clin Sci (Lond). 2015 Nov;129(9):809-22. doi: 10.1042/CS20140592. Epub 2015 Jul 2.

PMID:
26201092
3.

[Effect of down-regulation of Oct4 gene on biological characteristics of MDA-MB-231 breast cancer stem cells].

[No authors listed]

Zhonghua Zhong Liu Za Zhi. 2015 Apr;37(4):251-7. Chinese.

PMID:
26462888
4.

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM.

Gastroenterology. 2009 Aug;137(2):629-38. doi: 10.1053/j.gastro.2009.04.059. Epub 2009 May 7.

PMID:
19427313
5.

Smoothened activates breast cancer stem-like cell and promotes tumorigenesis and metastasis of breast cancer.

Wang L, Duan W, Kang L, Mao J, Yu X, Fan S, Li L, Tao Y.

Biomed Pharmacother. 2014 Oct;68(8):1099-104. doi: 10.1016/j.biopha.2014.09.012. Epub 2014 Oct 3.

PMID:
25451166
6.

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.

Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.

Cancer Lett. 2013 Oct 10;339(2):185-94. doi: 10.1016/j.canlet.2013.06.010. Epub 2013 Jun 18.

PMID:
23791879
7.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431. Print 2013.

8.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

9.

[Silencing hypoxia inducible factor-2α gene by small interference RNA inhibits the growth of mammosphere cells in nude mice under hypoxic microenvironment].

Qu HB, Fan YM, Han ML, Zeng N, Zhu ZK, Liu H, Xie J, Wu CY, Tang WX.

Zhonghua Yi Xue Za Zhi. 2013 Apr 16;93(15):1182-7. Chinese.

PMID:
23902893
10.

Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.

Onishi H, Yamasaki A, Kawamoto M, Imaizumi A, Katano M.

Cancer Lett. 2016 Feb 28;371(2):143-50. doi: 10.1016/j.canlet.2015.11.012. Epub 2015 Nov 30.

PMID:
26655998
11.

CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance.

Yoon C, Park DJ, Schmidt B, Thomas NJ, Lee HJ, Kim TS, Janjigian YY, Cohen DJ, Yoon SS.

Clin Cancer Res. 2014 Aug 1;20(15):3974-88. doi: 10.1158/1078-0432.CCR-14-0011. Epub 2014 Jun 19.

12.

Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis.

Hui W, Kuisheng C, Hongxin Z, Yanzhi D, Zhihua Z, Hu Z.

Pak J Pharm Sci. 2014 Sep;27(5 Suppl):1661-7.

PMID:
25262515
13.

[Effects of specific small interfering RNA on Smoothened expression and LoVo cell proliferation and apoptosis].

Zhu DJ, Fang CH, Rong ZX, Liu SJ.

Nan Fang Yi Ke Da Xue Xue Bao. 2007 Sep;27(9):1414-7. Chinese.

14.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

15.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.

PMID:
24063979
16.

Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1.

Yu D, Shin HS, Lee YS, Lee D, Kim S, Lee YC.

Oncol Rep. 2014 Feb;31(2):673-8. doi: 10.3892/or.2013.2893. Epub 2013 Dec 2.

PMID:
24297371
17.

Smoothened as a new therapeutic target for human osteosarcoma.

Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.

Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.

18.

[Biological effect of down-regulating of MTRR gene on cisplatin-resistant ovarian cancer SKOV3 cells in vitro and in vivo studies].

Chen J, Wang Q, Zhang W, Li L.

Zhonghua Fu Chan Ke Za Zhi. 2016 Feb;51(2):126-34. doi: 10.3760/cma.j.issn.0529-567X.2016.02.009. Chinese.

PMID:
26917482
19.

[Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro].

Peng L, Li FX, Shao WF, Xiong JB.

Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1421-6. Chinese.

20.

Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.

Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, Jiang KR, Chen P, Xu ZK, Miao Y.

Swiss Med Wkly. 2011 May 31;141:w13208. doi: 10.4414/smw.2011.13208.

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