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Items: 1 to 20 of 319

1.

Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation.

Bei Y, Hua-Huy T, Duong-Quy S, Nguyen VH, Chen W, Nicco C, Batteux F, Dinh-Xuan AT.

Pulm Pharmacol Ther. 2013 Dec;26(6):635-43. doi: 10.1016/j.pupt.2013.07.008. Epub 2013 Aug 6.

PMID:
23928001
2.

Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

Jiang C, Huang H, Liu J, Wang Y, Lu Z, Xu Z.

Int J Mol Sci. 2012;13(7):8293-307. doi: 10.3390/ijms13078293. Epub 2012 Jul 4.

3.

RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.

Bei Y, Hua-Huy T, Nicco C, Duong-Quy S, Le-Dong NN, Tiev KP, Chéreau C, Batteux F, Dinh-Xuan AT.

Exp Lung Res. 2016;42(1):44-55. doi: 10.3109/01902148.2016.1141263.

PMID:
26873329
4.

Endothelin-1-Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups.

Gien J, Tseng N, Seedorf G, Kuhn K, Abman SH.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1090-L1100. doi: 10.1152/ajplung.00066.2016. Epub 2016 Oct 19.

5.

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

Yasuda T, Tada Y, Tanabe N, Tatsumi K, West J.

Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L667-74. doi: 10.1152/ajplung.00423.2010. Epub 2011 Aug 19.

6.

NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis.

Liu CP, Kuo MS, Wu BN, Chai CY, Huang HT, Chung PW, Chen IJ.

Pulm Pharmacol Ther. 2014 Feb;27(1):17-28. doi: 10.1016/j.pupt.2013.03.003. Epub 2013 Mar 19.

PMID:
23518214
7.

[Fasudil reverses monocrotaline-induced pulmonary hypertension in rats].

Jiang H, Guan RJ, Wang HY.

Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Mar;41(3):239-44. Chinese.

PMID:
23879951
8.

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats.

Qi XJ, Ning W, Xu F, Dang HX, Fang F, Li J.

Int J Clin Exp Pathol. 2015 Oct 1;8(10):12140-50. eCollection 2015.

9.

Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

Li F, Xia W, Li A, Zhao C, Sun R.

Pharmacol Res. 2007 Jan;55(1):64-71. Epub 2006 Nov 1.

PMID:
17127075
10.

Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.

Li FH, Xia W, Li AW, Zhao CF, Sun RP.

Chin Med J (Engl). 2007 Jan 5;120(1):22-9.

PMID:
17254483
11.

[Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line].

Jiang C, Huang H, Liu J, Wang Y, Zhao Y, Xu Z.

Zhonghua Jie He He Hu Xi Za Zhi. 2014 Sep;37(9):671-6. Chinese.

PMID:
25533689
12.

Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide.

McNamara PJ, Murthy P, Kantores C, Teixeira L, Engelberts D, van Vliet T, Kavanagh BP, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L205-13. Epub 2007 Nov 21.

13.

PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.

Hemnes AR, Zaiman A, Champion HC.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L24-33. Epub 2007 Oct 26.

14.

A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.

Takemasa A, Ishii Y, Fukuda T.

Eur Respir J. 2012 Dec;40(6):1475-82. doi: 10.1183/09031936.00127011. Epub 2012 Mar 22. Erratum in: Eur Respir J. 2014 Oct;44(4):1101.

15.

Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition.

Lu GX, Bian DF, Ji Y, Guo JM, Wei ZF, Jiang SD, Xia YF, Dai Y.

Phytother Res. 2014 Aug;28(8):1224-31. doi: 10.1002/ptr.5120. Epub 2014 Jan 23.

PMID:
24458872
16.

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.

Baba I, Egi Y, Utsumi H, Kakimoto T, Suzuki K.

Mol Med Rep. 2015 Dec;12(6):8010-20. doi: 10.3892/mmr.2015.4467. Epub 2015 Oct 21.

17.

Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.

Gosal K, Dunlop K, Dhaliwal R, Ivanovska J, Kantores C, Desjardins JF, Connelly KA, McNamara PJ, Jain A, Jankov RP.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):717-27. doi: 10.1165/rcmb.2014-0201OC.

PMID:
25337652
18.

Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.

Hu H, Chen W, Ding J, Jia M, Yin J, Guo Z.

Exp Mol Pathol. 2015 Apr;98(2):277-85. doi: 10.1016/j.yexmp.2015.02.006. Epub 2015 Feb 16.

PMID:
25697583
19.

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.

Abe K, Tawara S, Oi K, Hizume T, Uwatoku T, Fukumoto Y, Kaibuchi K, Shimokawa H.

J Cardiovasc Pharmacol. 2006 Dec;48(6):280-5.

PMID:
17204906
20.

Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure.

Xueyang D, Zhanqiang M, Chunhua M, Kun H.

Oncotarget. 2016 Nov 29;7(48):78764-78772. doi: 10.18632/oncotarget.12853.

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