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Items: 1 to 20 of 90

1.

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW.

J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27.

PMID:
23927482
2.

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.

Eng WS, Hocková D, Špaček P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW.

J Med Chem. 2015 Jun 11;58(11):4822-38. doi: 10.1021/acs.jmedchem.5b00611. Epub 2015 May 13.

PMID:
25915781
3.

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.

Guddat LW, Vos S, Martin JL, Keough DT, de Jersey J.

Protein Sci. 2002 Jul;11(7):1626-38.

5.

Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase.

Ullman B, Cyr N, Choi K, Jardim A.

Int J Biochem Cell Biol. 2010 Feb;42(2):253-62. doi: 10.1016/j.biocel.2009.10.020. Epub 2009 Oct 25.

PMID:
19861168
6.

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19.

PMID:
23448281
7.

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.

Keough DT, Hocková D, Janeba Z, Wang TH, Naesens L, Edstein MD, Chavchich M, Guddat LW.

J Med Chem. 2015 Jan 22;58(2):827-46. doi: 10.1021/jm501416t. Epub 2014 Dec 24.

PMID:
25494538
8.

Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes.

Sujay Subbayya IN, Sukumaran S, Shivashankar K, Balaram H.

Biochem Biophys Res Commun. 2000 Jun 7;272(2):596-602.

PMID:
10833458
9.

Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.

Biazus G, Schneider CZ, Palma MS, Basso LA, Santos DS.

Protein Expr Purif. 2009 Aug;66(2):185-90. doi: 10.1016/j.pep.2009.04.001. Epub 2009 Apr 10.

PMID:
19362594
10.

Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Hocková D, Wang TH, Dračínský M, Poštová-Slavětínská L, Procházková E, Edstein MD, Chavchich M, Keough DT, Guddat LW, Janeba Z.

ChemMedChem. 2015 Oct;10(10):1707-23. doi: 10.1002/cmdc.201500322. Epub 2015 Aug 25.

PMID:
26368337
11.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Trésaugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P.

FEBS J. 2010 Dec;277(23):4920-30. doi: 10.1111/j.1742-4658.2010.07897.x. Epub 2010 Nov 5.

12.

Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase.

Lee CC, Medrano FJ, Craig SP 3rd, Eakin AE.

Biochim Biophys Acta. 2001 Jul 27;1537(1):63-70.

14.

A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.

Argos P, Hanei M, Wilson JM, Kelley WN.

J Biol Chem. 1983 May 25;258(10):6450-7.

15.

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.

Keough DT, Hocková D, Krecmerová M, Cesnek M, Holý A, Naesens L, Brereton IM, Winzor DJ, de Jersey J, Guddat LW.

Mol Biochem Parasitol. 2010 Oct;173(2):165-9. doi: 10.1016/j.molbiopara.2010.05.018. Epub 2010 Jun 1.

PMID:
20595032
16.
18.

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.

Hocková D, Janeba Z, Naesens L, Edstein MD, Chavchich M, Keough DT, Guddat LW.

Bioorg Med Chem. 2015 Sep 1;23(17):5502-10. doi: 10.1016/j.bmc.2015.07.038. Epub 2015 Jul 27.

PMID:
26275679
19.

Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).

Shi W, Munagala NR, Wang CC, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC.

Biochemistry. 2000 Jun 13;39(23):6781-90.

PMID:
10841757
20.

[Cloning, expression and characterization of the hypoxanthine-guanine phosphoribosyltransferase mutants from T. tengcongensis].

You DL, Qu H, Chen Q, Xing Y, Gu XC, Luo M.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Sep;35(9):853-8. Chinese.

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