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The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks.

Hu J, Hu Z, Mo Y, Wu Q, Cui Z, Duan Z, Huang J, Chen H, Chen Y, Gu M, Wang X, Hu S, Liu H, Liu W, Liu X, Liu X.

J Virol. 2013 Oct;87(20):11063-75. doi: 10.1128/JVI.00760-13. Epub 2013 Aug 7.


The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice.

Hu J, Hu Z, Song Q, Gu M, Liu X, Wang X, Hu S, Chen C, Liu H, Liu W, Chen S, Peng D, Liu X.

J Virol. 2013 Mar;87(5):2660-72. doi: 10.1128/JVI.02891-12. Epub 2012 Dec 19.


The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks.

Kajihara M, Sakoda Y, Soda K, Minari K, Okamatsu M, Takada A, Kida H.

Virol J. 2013 Feb 2;10:45. doi: 10.1186/1743-422X-10-45.


Differential immune response of mallard duck peripheral blood mononuclear cells to two highly pathogenic avian influenza H5N1 viruses with distinct pathogenicity in mallard ducks.

Cui Z, Hu J, He L, Li Q, Gu M, Wang X, Hu S, Liu H, Liu W, Liu X, Liu X.

Arch Virol. 2014 Feb;159(2):339-43. doi: 10.1007/s00705-013-1820-6. Epub 2013 Aug 21.


Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks.

Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG.

J Virol. 2007 Aug;81(16):8515-24. Epub 2007 Jun 6.


NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens.

Tada T, Suzuki K, Sakurai Y, Kubo M, Okada H, Itoh T, Tsukamoto K.

J Virol. 2011 Feb;85(4):1834-46. doi: 10.1128/JVI.01648-10. Epub 2010 Dec 1.


PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response.

Hu J, Mo Y, Wang X, Gu M, Hu Z, Zhong L, Wu Q, Hao X, Hu S, Liu W, Liu H, Liu X, Liu X.

J Virol. 2015 Apr;89(8):4126-42. doi: 10.1128/JVI.02132-14. Epub 2015 Jan 28.


Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals.

Fan S, Hatta M, Kim JH, Le MQ, Neumann G, Kawaoka Y.

J Virol. 2014 Dec;88(23):13737-46. doi: 10.1128/JVI.01081-14. Epub 2014 Sep 17.


Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks.

Schat KA, Bingham J, Butler JM, Chen LM, Lowther S, Crowley TM, Moore RJ, Donis RO, Lowenthal JW.

PLoS One. 2012;7(2):e30960. doi: 10.1371/journal.pone.0030960. Epub 2012 Feb 21.


Proteins of duck influenza virus responsible for acquisition of pathogenicity in chickens.

Yamamoto N, Soda K, Sakoda Y, Okamatsu M, Kida H.

Virus Res. 2013 May;173(2):294-8. doi: 10.1016/j.virusres.2013.02.001. Epub 2013 Feb 19.


The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks.

Song J, Feng H, Xu J, Zhao D, Shi J, Li Y, Deng G, Jiang Y, Li X, Zhu P, Guan Y, Bu Z, Kawaoka Y, Chen H.

J Virol. 2011 Mar;85(5):2180-8. doi: 10.1128/JVI.01975-10. Epub 2010 Dec 22.


Adaptive mutations in PB2 gene contribute to the high virulence of a natural reassortant H5N2 avian influenza virus in mice.

Li Q, Wang X, Sun Z, Hu J, Gao Z, Hao X, Li J, Liu H, Wang X, Gu M, Xu X, Liu X, Liu X.

Virus Res. 2015 Dec 2;210:255-63. doi: 10.1016/j.virusres.2015.08.017. Epub 2015 Aug 24.


A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.

Tan L, Su S, Smith DK, He S, Zheng Y, Shao Z, Ma J, Zhu H, Zhang G.

J Virol. 2014 Dec;88(24):14116-25. doi: 10.1128/JVI.01736-14. Epub 2014 Oct 1.


[Role of amino acid residues at positions 322 and 329 of hemagglutinin in virulence of H5N1 avian influenza virus].

Tang YH, Wu PP, Sun Q, Peng DX, Zhang WJ, Li YF, Wang WB, Long JX, Zhang PH, Liu XF.

Bing Du Xue Bao. 2008 Sep;24(5):340-4. Chinese.


iTRAQ-based quantitative proteomics reveals important host factors involved in the high pathogenicity of the H5N1 avian influenza virus in mice.

Hu J, Gao Z, Wang X, Gu M, Liang Y, Liu X, Hu S, Liu H, Liu W, Chen S, Peng D, Liu X.

Med Microbiol Immunol. 2017 Apr;206(2):125-147. doi: 10.1007/s00430-016-0489-3. Epub 2016 Dec 20.


Caspase-1 deficient mice are more susceptible to influenza A virus infection with PA variation.

Huang CH, Chen CJ, Yen CT, Yu CP, Huang PN, Kuo RL, Lin SJ, Chang CK, Shih SR.

J Infect Dis. 2013 Dec 1;208(11):1898-905. doi: 10.1093/infdis/jit381. Epub 2013 Jul 30.


The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice.

Forero A, Tisoncik-Go J, Watanabe T, Zhong G, Hatta M, Tchitchek N, Selinger C, Chang J, Barker K, Morrison J, Berndt JD, Moon RT, Josset L, Kawaoka Y, Katze MG.

J Virol. 2015 Dec 9;90(5):2240-53. doi: 10.1128/JVI.02974-15.


The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice.

Zaraket H, Bridges OA, Russell CJ.

J Virol. 2013 May;87(9):4826-34. doi: 10.1128/JVI.03110-12. Epub 2013 Feb 28.


Characterization of H5N1 influenza A viruses isolated from domestic green-winged teal.

Chen J, Yang Z, Chen Q, Liu X, Fang F, Chang H, Li D, Chen Z.

Virus Genes. 2009 Feb;38(1):66-73. doi: 10.1007/s11262-008-0289-y. Epub 2008 Sep 30.


Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene.

Long JX, Peng DX, Liu YL, Wu YT, Liu XF.

Virus Genes. 2008 Jun;36(3):471-8. doi: 10.1007/s11262-007-0187-8. Epub 2008 Mar 4.


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