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The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro.

Welin A, Amirbeagi F, Christenson K, Björkman L, Björnsdottir H, Forsman H, Dahlgren C, Karlsson A, Bylund J.

PLoS One. 2013 Jul 29;8(7):e69575. doi: 10.1371/journal.pone.0069575. Print 2013.


Olfactomedin-4 autoantibodies give unusual c-ANCA staining patterns with reactivity to a subpopulation of neutrophils.

Amirbeagi F, Thulin P, Pullerits R, Pedersen B, Andersson BA, Dahlgren C, Welin A, Bylund J.

J Leukoc Biol. 2015 Jan;97(1):181-9. doi: 10.1189/jlb.5A0614-311R. Epub 2014 Nov 11.


Olfactomedin 4 defines a subset of human neutrophils.

Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N.

J Leukoc Biol. 2012 Mar;91(3):495-500. doi: 10.1189/jlb.0811417. Epub 2011 Dec 20.


Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells.

Liu RH, Yang MH, Xiang H, Bao LM, Yang HA, Yue LW, Jiang X, Ang N, Wu LY, Huang Y.

J Biomed Sci. 2012 Apr 3;19:38. doi: 10.1186/1423-0127-19-38.


Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice.

Liu W, Yan M, Liu Y, McLeish KR, Coleman WG Jr, Rodgers GP.

J Immunol. 2012 Sep 1;189(5):2460-7. doi: 10.4049/jimmunol.1103179. Epub 2012 Jul 27.


Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer.

Clemmensen SN, Glenthøj AJ, Heebøll S, Nielsen HJ, Koch C, Borregaard N.

J Cell Mol Med. 2015 Dec;19(12):2865-73. doi: 10.1111/jcmm.12679. Epub 2015 Sep 28.


Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer.

Liu W, Rodgers GP.

Cancer Metastasis Rev. 2016 Jun;35(2):201-12. doi: 10.1007/s10555-016-9624-2. Review.


Fish cast NETs: neutrophil extracellular traps are released from fish neutrophils.

Palić D, Ostojić J, Andreasen CB, Roth JA.

Dev Comp Immunol. 2007;31(8):805-16. Epub 2006 Dec 29.


Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells.

Kobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N.

Cancer Sci. 2007 Mar;98(3):334-40.


Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase.

Azevedo EP, Guimarães-Costa AB, Torezani GS, Braga CA, Palhano FL, Kelly JW, Saraiva EM, Foguel D.

J Biol Chem. 2012 Oct 26;287(44):37206-18. doi: 10.1074/jbc.M112.369942. Epub 2012 Aug 23.


Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia.

Gupta AK, Hasler P, Holzgreve W, Gebhardt S, Hahn S.

Hum Immunol. 2005 Nov;66(11):1146-54. Epub 2006 Jan 4.


Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.

Gersemann M, Becker S, Nuding S, Antoni L, Ott G, Fritz P, Oue N, Yasui W, Wehkamp J, Stange EF.

J Crohns Colitis. 2012 May;6(4):425-34. doi: 10.1016/j.crohns.2011.09.013. Epub 2011 Nov 15.


Neutrophil extracellular traps: how to generate and visualize them.

Brinkmann V, Laube B, Abu Abed U, Goosmann C, Zychlinsky A.

J Vis Exp. 2010 Feb 24;(36). pii: 1724. doi: 10.3791/1724.


OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer.

Luo Z, Zhang Q, Zhao Z, Li B, Chen J, Wang Y.

J Cancer Res Clin Oncol. 2011 Nov;137(11):1713-20. doi: 10.1007/s00432-011-1042-9. Epub 2011 Sep 9.


Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential.

Keshari RS, Jyoti A, Kumar S, Dubey M, Verma A, Srinag BS, Krishnamurthy H, Barthwal MK, Dikshit M.

Cytometry A. 2012 Mar;81(3):238-47. doi: 10.1002/cyto.a.21178. Epub 2011 Dec 13.

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