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Items: 1 to 20 of 96

1.

LRH-1: orphaned, adopted and needed for pregnancy.

Brosens JJ, Blanks AM, Lucas ES.

Nat Med. 2013 Aug;19(8):968-9. doi: 10.1038/nm.3271. No abstract available.

PMID:
23921740
2.

Liver receptor homolog-1 is essential for pregnancy.

Zhang C, Large MJ, Duggavathi R, DeMayo FJ, Lydon JP, Schoonjans K, Kovanci E, Murphy BD.

Nat Med. 2013 Aug;19(8):1061-6. doi: 10.1038/nm.3192. Epub 2013 Jun 30.

3.

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.

Fayard E, Auwerx J, Schoonjans K.

Trends Cell Biol. 2004 May;14(5):250-60. Review.

PMID:
15130581
4.

Molecular basis for the regulation of the nuclear receptor LRH-1.

Stein S, Schoonjans K.

Curr Opin Cell Biol. 2015 Apr;33:26-34. doi: 10.1016/j.ceb.2014.10.007. Epub 2014 Nov 15. Review.

PMID:
25463843
5.

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, Auwerx J.

EMBO Rep. 2002 Dec;3(12):1181-7. Epub 2002 Nov 21.

6.

Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells.

Yang FM, Pan CT, Tsai HM, Chiu TW, Wu ML, Hu MC.

FEBS J. 2009 Jan;276(2):425-36. doi: 10.1111/j.1742-4658.2008.06785.x.

7.

SUMOylation places LRH-1 in PROXimity to lipid metabolism.

Priest C, Tontonoz P.

Cell Metab. 2014 Oct 7;20(4):558-9. doi: 10.1016/j.cmet.2014.09.008.

8.

Regulation of miR-200c by nuclear receptors PPAR╬▒, LRH-1 and SHP.

Zhang Y, Yang Z, Whitby R, Wang L.

Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):135-9. doi: 10.1016/j.bbrc.2011.11.011. Epub 2011 Nov 11.

9.

Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes.

Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V, Rainey WE.

J Endocrinol. 2002 Sep;174(3):R13-7.

10.

Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-╬▓.

Lazarus KA, Brown KA, Young MJ, Zhao Z, Coulson RS, Chand AL, Clyne CD.

Endocrinology. 2014 May;155(5):1606-17. doi: 10.1210/en.2013-1948. Epub 2014 Feb 24.

PMID:
24564400
11.

A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding.

Yang FM, Feng SJ, Lai TC, Hu MC.

Biochem J. 2015 Oct 15;471(2):199-209. doi: 10.1042/BJ20150252. Epub 2015 Aug 12.

PMID:
26268559
12.

Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteins.

Ohno M, Komakine J, Suzuki E, Nishizuka M, Osada S, Imagawa M.

Biol Pharm Bull. 2010;33(5):784-91.

13.

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.

Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD.

Elife. 2014 Apr 15;3:e01694. doi: 10.7554/eLife.01694. Erratum in: Elife. 2015;4:e10084.

14.

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.

Chong HK, Biesinger J, Seo YK, Xie X, Osborne TF.

BMC Genomics. 2012 Feb 1;13:51. doi: 10.1186/1471-2164-13-51.

15.

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine.

Mueller M, Cima I, Noti M, Fuhrer A, Jakob S, Dubuquoy L, Schoonjans K, Brunner T.

J Exp Med. 2006 Sep 4;203(9):2057-62. Epub 2006 Aug 21.

16.

Cytoplasmic localization of Lrh-1 down-regulates ovarian follicular cyp19a1a expression in a teleost, the orange-spotted grouper Epinephelus coioides.

Lu H, Zhang S, Liu Q, Zhang L, Zhang W.

Biol Reprod. 2014 Aug;91(2):29. doi: 10.1095/biolreprod.114.117952. Epub 2014 Jun 18.

PMID:
24943038
17.

Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation.

Lee YK, Choi YH, Chua S, Park YJ, Moore DD.

J Biol Chem. 2006 Mar 24;281(12):7850-5. Epub 2006 Jan 25.

18.

Antiproliferation activity of a small molecule repressor of liver receptor homolog 1.

Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR.

Mol Pharmacol. 2015 Feb;87(2):296-304. doi: 10.1124/mol.114.095554. Epub 2014 Dec 3.

19.

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, Auwerx J.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2058-62. Epub 2005 Jan 31.

20.

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation.

Botrugno OA, Fayard E, Annicotte JS, Haby C, Brennan T, Wendling O, Tanaka T, Kodama T, Thomas W, Auwerx J, Schoonjans K.

Mol Cell. 2004 Aug 27;15(4):499-509.

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