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Items: 1 to 20 of 120

1.

Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model.

Redmond DE Jr, McEntire CR, Kingsbery JP, Leranth C, Elsworth JD, Bjugstad KB, Roth RH, Samulski RJ, Sladek JR Jr.

Mol Ther. 2013 Dec;21(12):2160-8. doi: 10.1038/mt.2013.180. Epub 2013 Aug 5.

2.

Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target.

Wakeman DR, Redmond DE Jr, Dodiya HB, Sladek JR Jr, Leranth C, Teng YD, Samulski RJ, Snyder EY.

Stem Cells Transl Med. 2014 Jun;3(6):692-701. doi: 10.5966/sctm.2013-0208. Epub 2014 Apr 17.

3.

AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.

Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH.

Exp Neurol. 2008 May;211(1):252-8. doi: 10.1016/j.expneurol.2008.01.026. Epub 2008 Feb 15.

4.

Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons.

Yurek DM, Flectcher AM, Kowalczyk TH, Padegimas L, Cooper MJ.

Cell Transplant. 2009;18(10):1183-96. doi: 10.3727/096368909X12483162196881. Epub 2009 Jun 22.

5.

Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.

Redmond DE Jr, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR Jr.

J Comp Neurol. 2009 Jul 1;515(1):31-40. doi: 10.1002/cne.22028.

6.

Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery.

Drinkut A, Tereshchenko Y, Schulz JB, Bähr M, Kügler S.

Mol Ther. 2012 Mar;20(3):534-43. doi: 10.1038/mt.2011.249. Epub 2011 Nov 15.

7.

Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study.

Elsworth JD, Brittan MS, Taylor JR, Sladek JR Jr, Redmond DE Jr, Innis RB, Zea-Ponce Y, Roth RH.

Brain Res. 1998 Jun 8;795(1-2):55-62.

PMID:
9622593
9.

The DaNeX study of embryonic mesencephalic, dopaminergic tissue grafted to a minipig model of Parkinson's disease: preliminary findings of effect of MPTP poisoning on striatal dopaminergic markers.

Danielsen EH, Cumming P, Andersen F, Bender D, Brevig T, Falborg L, Gee A, Gillings NM, Hansen SB, Hermansen F, Johansen J, Johansen TE, Dahl-Jørgensen A, Jørgensen HA, Meyer M, Munk O, Pedersen EB, Poulsen PH, Rodell AB, Sakoh M, Simonsen CZ, Smith DF, Sørensen JC, Ostergård L, Zimmer J, Gjedde A, Møller A.

Cell Transplant. 2000 Mar-Apr;9(2):247-59.

PMID:
10811397
11.
12.

Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys.

Elsworth JD, Brittan MS, Taylor JR, Sladek JR Jr, al-Tikriti MS, Zea-Ponce Y, Innis RB, Redmond DE Jr, Roth RH.

Cell Transplant. 1996 Mar-Apr;5(2):315-25.

PMID:
8689042
13.

Co-transplantation of GDNF-overexpressing neural stem cells and fetal dopaminergic neurons mitigates motor symptoms in a rat model of Parkinson's disease.

Deng X, Liang Y, Lu H, Yang Z, Liu R, Wang J, Song X, Long J, Li Y, Lei D, Feng Z.

PLoS One. 2013 Dec 3;8(12):e80880. doi: 10.1371/journal.pone.0080880. eCollection 2013.

14.

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S, Roitberg BZ, Brown WD, Holden JE, Pyzalski R, Taylor MD, Carvey P, Ling Z, Trono D, Hantraye P, Déglon N, Aebischer P.

Science. 2000 Oct 27;290(5492):767-73.

15.

Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation.

Villadiego J, Méndez-Ferrer S, Valdés-Sánchez T, Silos-Santiago I, Fariñas I, López-Barneo J, Toledo-Aral JJ.

J Neurosci. 2005 Apr 20;25(16):4091-8.

17.

MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector.

Chen YH, Harvey BK, Hoffman AF, Wang Y, Chiang YH, Lupica CR.

FASEB J. 2008 Jan;22(1):261-75. Epub 2007 Aug 9.

PMID:
17690153
18.

Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys.

Taylor JR, Elsworth JD, Sladek JR Jr, Collier TJ, Roth RH, Redmond DE Jr.

Cell Transplant. 1995 Jan-Feb;4(1):13-26.

PMID:
7728327
19.

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum.

Granholm AC, Mott JL, Bowenkamp K, Eken S, Henry S, Hoffer BJ, Lapchak PA, Palmer MR, van Horne C, Gerhardt GA.

Exp Brain Res. 1997 Aug;116(1):29-38.

PMID:
9305812
20.

Quantitative [18F]fluorodopa/PET and histology of fetal mesencephalic dopaminergic grafts to the striatum of MPTP-poisoned minipigs.

Dall AM, Danielsen EH, Sørensen JC, Andersen F, Møller A, Zimmer J, Gjedde AH, Cumming P; Danish Neuronal Xenografting Group.

Cell Transplant. 2002;11(8):733-46.

PMID:
12588105

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