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Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.

Liszczak G, Goldberg JM, Foyn H, Petersson EJ, Arnesen T, Marmorstein R.

Nat Struct Mol Biol. 2013 Sep;20(9):1098-105. doi: 10.1038/nsmb.2636. Epub 2013 Aug 4.


Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog.

Liszczak G, Marmorstein R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14652-7. doi: 10.1073/pnas.1310365110. Epub 2013 Aug 19.


A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).

Arnesen T, Gromyko D, Kagabo D, Betts MJ, Starheim KK, Varhaug JE, Anderson D, Lillehaug JR.

BMC Biochem. 2009 May 29;10:15. doi: 10.1186/1471-2091-10-15.


Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity.

Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR.

J Biol Chem. 2009 Nov 6;284(45):31122-9. doi: 10.1074/jbc.M109.001347. Epub 2009 Sep 10.


Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase.

Van Damme P, Evjenth R, Foyn H, Demeyer K, De Bock PJ, Lillehaug JR, Vandekerckhove J, Arnesen T, Gevaert K.

Mol Cell Proteomics. 2011 May;10(5):M110.004580. doi: 10.1074/mcp.M110.004580. Epub 2011 Mar 7.


A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant.

Van Damme P, Støve SI, Glomnes N, Gevaert K, Arnesen T.

Mol Cell Proteomics. 2014 Aug;13(8):2031-41. doi: 10.1074/mcp.M113.035402. Epub 2014 Jan 9.


The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.

Arnesen T, Starheim KK, Van Damme P, Evjenth R, Dinh H, Betts MJ, Ryningen A, Vandekerckhove J, Gevaert K, Anderson D.

Mol Cell Biol. 2010 Apr;30(8):1898-909. doi: 10.1128/MCB.01199-09. Epub 2010 Feb 12.


The N-terminal acetyltransferase Naa10 is essential for zebrafish development.

Ree R, Myklebust LM, Thiel P, Foyn H, Fladmark KE, Arnesen T.

Biosci Rep. 2015 Aug 6;35(5). pii: e00249. doi: 10.1042/BSR20150168.


Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation.

Liszczak G, Arnesen T, Marmorstein R.

J Biol Chem. 2011 Oct 21;286(42):37002-10. doi: 10.1074/jbc.M111.282863. Epub 2011 Sep 6.


Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.

Arnesen T, Van Damme P, Polevoda B, Helsens K, Evjenth R, Colaert N, Varhaug JE, Vandekerckhove J, Lillehaug JR, Sherman F, Gevaert K.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8157-62. doi: 10.1073/pnas.0901931106. Epub 2009 May 6.


The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.

Hole K, Van Damme P, Dalva M, Aksnes H, Glomnes N, Varhaug JE, Lillehaug JR, Gevaert K, Arnesen T.

PLoS One. 2011;6(9):e24713. doi: 10.1371/journal.pone.0024713. Epub 2011 Sep 15.


The N-terminal Acetyltransferase Naa10/ARD1 Does Not Acetylate Lysine Residues.

Magin RS, March ZM, Marmorstein R.

J Biol Chem. 2016 Mar 4;291(10):5270-7. doi: 10.1074/jbc.M115.709428. Epub 2016 Jan 11.


Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.

Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T.

ACS Chem Biol. 2013;8(6):1121-7. doi: 10.1021/cb400136s. Epub 2013 Apr 4.


Sequence requirements for Nalpha-terminal acetylation of yeast proteins by NatA.

Perrot M, Massoni A, Boucherie H.

Yeast. 2008 Jul;25(7):513-27. doi: 10.1002/yea.1602.


Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase.

Yates LA, Fleurdépine S, Rissland OS, De Colibus L, Harlos K, Norbury CJ, Gilbert RJ.

Nat Struct Mol Biol. 2012 Aug;19(8):782-7. doi: 10.1038/nsmb.2329. Epub 2012 Jul 1.


N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.

Van Damme P, Hole K, Gevaert K, Arnesen T.

Proteomics. 2015 Jul;15(14):2436-46. doi: 10.1002/pmic.201400575. Epub 2015 Jun 5.


Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.

Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T.

Mol Cell Biol. 2009 Jul;29(13):3569-81. doi: 10.1128/MCB.01909-08. Epub 2009 Apr 27.


N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins.

Polevoda B, Sherman F.

J Mol Biol. 2003 Jan 24;325(4):595-622. Review.


Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.

Støve SI, Magin RS, Foyn H, Haug BE, Marmorstein R, Arnesen T.

Structure. 2016 Jul 6;24(7):1044-56. doi: 10.1016/j.str.2016.04.020. Epub 2016 Jun 16.


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