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Items: 1 to 20 of 92

1.

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N.

Cancer Cell. 2013 Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Erratum in: Cancer Cell. 2013 Sep 9;24(3):399.

2.

Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.

Xi F, Ye J.

Oncol Res. 2016;23(1-2):53-9. doi: 10.3727/096504015X14459480491740.

PMID:
26802651
3.

Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells.

Kudryavtseva AV, Fedorova MS, Zhavoronkov A, Moskalev AA, Zasedatelev AS, Dmitriev AA, Sadritdinova AF, Karpova IY, Nyushko KM, Kalinin DV, Volchenko NN, Melnikova NV, Klimina KM, Sidorov DV, Popov AY, Nasedkina TV, Kaprin AD, Alekseev BY, Krasnov GS, Snezhkina AV.

BMC Genet. 2016 Dec 22;17(Suppl 3):156. doi: 10.1186/s12863-016-0459-1.

4.

Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.

Palmieri D, Fitzgerald D, Shreeve SM, Hua E, Bronder JL, Weil RJ, Davis S, Stark AM, Merino MJ, Kurek R, Mehdorn HM, Davis G, Steinberg SM, Meltzer PS, Aldape K, Steeg PS.

Mol Cancer Res. 2009 Sep;7(9):1438-45. doi: 10.1158/1541-7786.MCR-09-0234. Epub 2009 Sep 1.

5.

Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth.

Ros S, Schulze A.

Cancer Discov. 2013 Oct;3(10):1105-7. doi: 10.1158/2159-8290.CD-13-0565.

6.

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.

Wolf A, Agnihotri S, Munoz D, Guha A.

Neurobiol Dis. 2011 Oct;44(1):84-91. doi: 10.1016/j.nbd.2011.06.007. Epub 2011 Jun 25.

PMID:
21726646
7.

Dicer mediating the expression of miR-143 and miR-155 regulates hexokinase II associated cellular response to hypoxia.

Yao M, Wang X, Tang Y, Zhang W, Cui B, Liu Q, Xing L.

Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L829-37. doi: 10.1152/ajplung.00081.2014. Epub 2014 Aug 29.

PMID:
25172909
8.

A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.

Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF.

EMBO J. 2012 Apr 18;31(8):1985-98. doi: 10.1038/emboj.2012.45. Epub 2012 Feb 21.

9.

Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation via suppression of HK2-modulated glucose metabolism.

Lv X, Yao L, Zhang J, Han P, Li C.

Mol Med Rep. 2016 Aug;14(2):1332-8. doi: 10.3892/mmr.2016.5394. Epub 2016 Jun 10.

PMID:
27315591
10.
11.

MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.

Fang R, Xiao T, Fang Z, Sun Y, Li F, Gao Y, Feng Y, Li L, Wang Y, Liu X, Chen H, Liu XY, Ji H.

J Biol Chem. 2012 Jun 29;287(27):23227-35. doi: 10.1074/jbc.M112.373084. Epub 2012 May 16.

12.

Hexokinase 2 is a determinant of neuroblastoma metastasis.

Botzer LE, Maman S, Sagi-Assif O, Meshel T, Nevo I, Yron I, Witz IP.

Br J Cancer. 2016 Mar 29;114(7):759-66. doi: 10.1038/bjc.2016.26. Epub 2016 Mar 17.

13.

[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].

Krasnov GS, Dmitriev AA, Sadtritdinova AF, Fedorova MS, Snezhkina AV, Melnikova NV, Poteryakhina AV, Nyushko KM, Belyakov MM, Kaprin AD, Zaretsky AR, Kudryavtseva AV.

Biofizika. 2015 Nov-Dec;60(6):1050-6. Russian.

PMID:
26855992
14.

Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.

Wang L, Xiong H, Wu F, Zhang Y, Wang J, Zhao L, Guo X, Chang LJ, Zhang Y, You MJ, Koochekpour S, Saleem M, Huang H, Lu J, Deng Y.

Cell Rep. 2014 Sep 11;8(5):1461-74. doi: 10.1016/j.celrep.2014.07.053. Epub 2014 Aug 28.

15.

miR-143 regulates hexokinase 2 expression in cancer cells.

Peschiaroli A, Giacobbe A, Formosa A, Markert EK, Bongiorno-Borbone L, Levine AJ, Candi E, D'Alessandro A, Zolla L, Finazzi Agrò A, Melino G.

Oncogene. 2013 Feb 7;32(6):797-802. doi: 10.1038/onc.2012.100. Epub 2012 Apr 2.

PMID:
22469988
16.

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection.

Tan VP, Miyamoto S.

Autophagy. 2015;11(6):963-4. doi: 10.1080/15548627.2015.1042195. Review.

17.

PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.

Zhuo B, Li Y, Li Z, Qin H, Sun Q, Zhang F, Shen Y, Shi Y, Wang R.

Biochem Biophys Res Commun. 2015 Aug 21;464(2):401-6. doi: 10.1016/j.bbrc.2015.06.092. Epub 2015 Jun 24.

PMID:
26116768
18.

Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells.

Neary CL, Pastorino JG.

J Cell Physiol. 2013 Sep;228(9):1943-8. doi: 10.1002/jcp.24361.

PMID:
23629924
19.

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.

Min JW, Kim KI, Kim HA, Kim EK, Noh WC, Jeon HB, Cho DH, Oh JS, Park IC, Hwang SG, Kim JS.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):137-42. doi: 10.1016/j.bbrc.2013.09.041. Epub 2013 Sep 17.

PMID:
24051093
20.

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, Hawkins C, Guha A.

J Exp Med. 2011 Feb 14;208(2):313-26. doi: 10.1084/jem.20101470. Epub 2011 Jan 17.

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