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In vitro regulation of hepatocellular carcinoma cell viability, apoptosis, invasion, and AEG-1 expression by LY294002.

Ma J, Xie SL, Geng YJ, Jin S, Wang GY, Lv GY.

Clin Res Hepatol Gastroenterol. 2014 Feb;38(1):73-80. doi: 10.1016/j.clinre.2013.06.012. Epub 2013 Jul 30.


Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors.

Lai JP, Sandhu DS, Yu C, Moser CD, Hu C, Shire AM, Aderca I, Murphy LM, Adjei AA, Sanderson S, Roberts LR.

Liver Int. 2010 Nov;30(10):1522-8. doi: 10.1111/j.1478-3231.2010.02336.x. Epub 2010 Sep 8.


MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo.

He XX, Chang Y, Meng FY, Wang MY, Xie QH, Tang F, Li PY, Song YH, Lin JS.

Oncogene. 2012 Jul 12;31(28):3357-69. doi: 10.1038/onc.2011.500. Epub 2011 Nov 7.


AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.

Zhou Z, Deng H, Yan W, Luo M, Tu W, Xia Y, He J, Han P, Fu Y, Tian D.

PLoS One. 2014 Jun 18;9(6):e100372. doi: 10.1371/journal.pone.0100372. eCollection 2014.


Suppressive effects of microRNA-16 on the proliferation, invasion and metastasis of hepatocellular carcinoma cells.

Wu WL, Wang WY, Yao WQ, Li GD.

Int J Mol Med. 2015 Dec;36(6):1713-9. doi: 10.3892/ijmm.2015.2379. Epub 2015 Oct 16.


The emerging role of astrocyte-elevated gene-1 in hepatocellular carcinoma (Review).

Zhu HD, Liao JZ, He XX, Li PY.

Oncol Rep. 2015 Aug;34(2):539-46. doi: 10.3892/or.2015.4024. Epub 2015 May 29. Review.


Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma.

Kunter I, Erdal E, Nart D, Yilmaz F, Karademir S, Sagol O, Atabey N.

Oncol Rep. 2014 Feb;31(2):573-80. doi: 10.3892/or.2013.2932. Epub 2013 Dec 16.


RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.

Wu J, Meng J, Du Y, Huang Y, Jin Y, Zhang J, Wang B, Zhang Y, Sun M, Tang J.

Biomed Pharmacother. 2013 May;67(4):313-9. doi: 10.1016/j.biopha.2013.01.011. Epub 2013 Feb 18.


Tetraspanin 8 mediates AEG-1-induced invasion and metastasis in hepatocellular carcinoma cells.

Akiel MA, Santhekadur PK, Mendoza RG, Siddiq A, Fisher PB, Sarkar D.

FEBS Lett. 2016 Aug;590(16):2700-8. doi: 10.1002/1873-3468.12268. Epub 2016 Jul 21.


Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine.

Xie X, Tang B, Zhou J, Gao Q, Zhang P.

Oncol Rep. 2013 Aug;30(2):773-82. doi: 10.3892/or.2013.2520. Epub 2013 Jun 5.


Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).

Srivastava J, Robertson CL, Gredler R, Siddiq A, Rajasekaran D, Akiel MA, Emdad L, Mas V, Mukhopadhyay ND, Fisher PB, Sarkar D.

J Biol Chem. 2015 Jun 19;290(25):15549-58. doi: 10.1074/jbc.M115.649707. Epub 2015 May 5.


PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway.

Tian T, Nan KJ, Guo H, Wang WJ, Ruan ZP, Wang SH, Liang X, Lu CX.

Oncol Rep. 2010 Jun;23(6):1593-600.


HBx elevates oncoprotein AEG-1 expression to promote cell migration by downregulating miR-375 and miR-136 in malignant hepatocytes.

Zhao J, Wang W, Huang Y, Wu J, Chen M, Cui P, Zhang W, Zhang Y.

DNA Cell Biol. 2014 Oct;33(10):715-22. doi: 10.1089/dna.2014.2376. Epub 2014 Jul 22.


Combination of Nanoparticle-Delivered siRNA for Astrocyte Elevated Gene-1 (AEG-1) and All-trans Retinoic Acid (ATRA): An Effective Therapeutic Strategy for Hepatocellular Carcinoma (HCC).

Rajasekaran D, Srivastava J, Ebeid K, Gredler R, Akiel M, Jariwala N, Robertson CL, Shen XN, Siddiq A, Fisher PB, Salem AK, Sarkar D.

Bioconjug Chem. 2015 Aug 19;26(8):1651-61. doi: 10.1021/acs.bioconjchem.5b00254. Epub 2015 Jun 25.


Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma.

Nie H, Cao Q, Zhu L, Gong Y, Gu J, He Z.

PLoS One. 2013 Apr 19;8(4):e61678. doi: 10.1371/journal.pone.0061678. Print 2013.


Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma.

Zhang Y, Takahashi S, Tasaka A, Yoshima T, Ochi H, Chayama K.

J Gastroenterol Hepatol. 2013 Mar;28(3):565-75. doi: 10.1111/j.1440-1746.2012.07271.x.


miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma.

Li Q, Ding C, Chen C, Zhang Z, Xiao H, Xie F, Lei L, Chen Y, Mao B, Jiang M, Li J, Wang D, Wang G.

J Gastroenterol Hepatol. 2014 Apr;29(4):835-42. doi: 10.1111/jgh.12429.


MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3.

Liu K, Li X, Cao Y, Ge Y, Wang J, Shi B.

Int J Oncol. 2015 Oct;47(4):1585-93. doi: 10.3892/ijo.2015.3112. Epub 2015 Aug 4.


Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma.

Zhao JJ, Pan K, Li JJ, Chen YB, Chen JG, Lv L, Wang DD, Pan QZ, Chen MS, Xia JC.

PLoS One. 2011;6(10):e26608. doi: 10.1371/journal.pone.0026608. Epub 2011 Oct 19.


Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma.

Chen D, Yoo BK, Santhekadur PK, Gredler R, Bhutia SK, Das SK, Fuller C, Su ZZ, Fisher PB, Sarkar D.

Clin Cancer Res. 2011 Nov 1;17(21):6693-701. doi: 10.1158/1078-0432.CCR-10-2774. Epub 2011 Sep 9.

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