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Items: 1 to 20 of 96

1.

MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells.

Lyons J, Bastian BC, McCormick F.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13845-50. doi: 10.1073/pnas.1201917110. Epub 2013 Aug 1.

2.

Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells.

Herraiz C, Journé F, Ghanem G, Jiménez-Cervantes C, García-Borrón JC.

Int J Biochem Cell Biol. 2012 Dec;44(12):2244-52. doi: 10.1016/j.biocel.2012.09.008. Epub 2012 Sep 19.

PMID:
23000456
3.

Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.

Herraiz C, Journé F, Abdel-Malek Z, Ghanem G, Jiménez-Cervantes C, García-Borrón JC.

Mol Endocrinol. 2011 Jan;25(1):138-56. doi: 10.1210/me.2010-0217. Epub 2010 Nov 17.

4.

Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors.

Sánchez-Más J, Guillo LA, Zanna P, Jiménez-Cervantes C, García-Borrón JC.

Mol Endocrinol. 2005 Apr;19(4):1035-48. Epub 2005 Jan 13.

PMID:
15650023
5.

Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways.

Herraiz C, Jiménez-Cervantes C, Zanna P, García-Borrón JC.

FEBS Lett. 2009 Oct 6;583(19):3269-74. doi: 10.1016/j.febslet.2009.09.023. Epub 2009 Sep 13.

6.

Cyclic AMP (cAMP) signaling in melanocytes and melanoma.

Rodríguez CI, Setaluri V.

Arch Biochem Biophys. 2014 Dec 1;563:22-7. doi: 10.1016/j.abb.2014.07.003. Epub 2014 Jul 10. Review.

PMID:
25017568
7.

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.

García-Borrón JC, Abdel-Malek Z, Jiménez-Cervantes C.

Pigment Cell Melanoma Res. 2014 Sep;27(5):699-720. doi: 10.1111/pcmr.12257. Epub 2014 May 30. Review.

8.

Agonist-independent, high constitutive activity of the human melanocortin 1 receptor.

Sánchez-Más J, Hahmann C, Gerritsen I, García-Borrón JC, Jiménez-Cervantes C.

Pigment Cell Res. 2004 Aug;17(4):386-95.

PMID:
15250941
9.

Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.

Pérez Oliva AB, Fernéndez LP, Detorre C, Herráiz C, Martínez-Escribano JA, Benítez J, Lozano Teruel JA, García-Borrón JC, Jiménez-Cervantes C, Ribas G.

Hum Mutat. 2009 May;30(5):811-22. doi: 10.1002/humu.20971.

PMID:
19338054
10.

Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles.

Beaumont KA, Shekar SN, Newton RA, James MR, Stow JL, Duffy DL, Sturm RA.

Hum Mol Genet. 2007 Sep 15;16(18):2249-60. Epub 2007 Jul 5. Erratum in: Hum Mol Genet. 2007 Dec 1;16(23):2988. Shekar, Sri L [corrected to Shekar, Sri N].

PMID:
17616515
11.

Rate limiting factors in melanocortin 1 receptor signalling through the cAMP pathway.

Más JS, Gerritsen I, Hahmann C, Jiménez-Cervantes C, García-Borrón JC.

Pigment Cell Res. 2003 Oct;16(5):540-7.

PMID:
12950734
12.
13.

Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells.

Newton RA, Smit SE, Barnes CC, Pedley J, Parsons PG, Sturm RA.

Peptides. 2005 Oct;26(10):1818-24.

PMID:
15992961
14.

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

Cazales M, Schmitt E, Montembault E, Dozier C, Prigent C, Ducommun B.

Cell Cycle. 2005 Sep;4(9):1233-8. Epub 2005 Sep 23.

PMID:
16082213
15.

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression.

Bugler B, Quaranta M, Aressy B, Brezak MC, Prevost G, Ducommun B.

Mol Cancer Ther. 2006 Jun;5(6):1446-51.

16.

Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B.

Park YH, Jeon YH, Kim IY.

Biochim Biophys Acta. 2012 Dec;1823(12):2217-26. doi: 10.1016/j.bbamcr.2012.09.001. Epub 2012 Sep 12.

17.

Human melanocytes expressing MC1R variant alleles show impaired activation of multiple signaling pathways.

Newton RA, Roberts DW, Leonard JH, Sturm RA.

Peptides. 2007 Dec;28(12):2387-96. Epub 2007 Oct 10.

PMID:
18006116
18.

Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor.

Herraiz C, Olivares C, Castejón-Griñán M, Abrisqueta M, Jiménez-Cervantes C, García-Borrón JC.

PLoS One. 2015 Dec 11;10(12):e0144757. doi: 10.1371/journal.pone.0144757. eCollection 2015.

19.

Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

Huang SH, Wu LW, Huang AC, Yu CC, Lien JC, Huang YP, Yang JS, Yang JH, Hsiao YP, Wood WG, Yu CS, Chung JG.

J Agric Food Chem. 2012 Jan 18;60(2):665-75. doi: 10.1021/jf204193v. Epub 2012 Jan 6.

PMID:
22148415
20.

Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

Sánchez Más J, Olivares Sánchez C, Ghanem G, Haycock J, Lozano Teruel JA, García-Borrón JC, Jiménez-Cervantes C.

Eur J Biochem. 2002 Dec;269(24):6133-41.

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