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Items: 1 to 20 of 104

1.

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes.

Cervantes JL, La Vake CJ, Weinerman B, Luu S, O'Connell C, Verardi PH, Salazar JC.

J Leukoc Biol. 2013 Dec;94(6):1231-41. doi: 10.1189/jlb.0413206. Epub 2013 Aug 1.

2.

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.

Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3683-8. doi: 10.1073/pnas.1013776108. Epub 2011 Feb 14.

3.

Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.

Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD.

PLoS Pathog. 2009 May;5(5):e1000444. doi: 10.1371/journal.ppat.1000444. Epub 2009 May 22.

4.

Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-κB-dependent cytokines.

Love AC, Schwartz I, Petzke MM.

Infect Immun. 2014 Jun;82(6):2405-16. doi: 10.1128/IAI.01617-14. Epub 2014 Mar 24.

5.

TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway.

Bergstrøm B, Aune MH, Awuh JA, Kojen JF, Blix KJ, Ryan L, Flo TH, Mollnes TE, Espevik T, Stenvik J.

J Immunol. 2015 Aug 1;195(3):1100-11. doi: 10.4049/jimmunol.1403176. Epub 2015 Jun 17.

6.

Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes.

Cruz AR, Moore MW, La Vake CJ, Eggers CH, Salazar JC, Radolf JD.

Infect Immun. 2008 Jan;76(1):56-70. Epub 2007 Oct 15.

7.

Phagosomal TLR signaling upon Borrelia burgdorferi infection.

Cervantes JL, Hawley KL, Benjamin SJ, Weinerman B, Luu SM, Salazar JC.

Front Cell Infect Microbiol. 2014 May 20;4:55. doi: 10.3389/fcimb.2014.00055. eCollection 2014. Review.

8.

Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway.

Dennis VA, Dixit S, O'Brien SM, Alvarez X, Pahar B, Philipp MT.

Infect Immun. 2009 Mar;77(3):1238-45. doi: 10.1128/IAI.01078-08. Epub 2009 Jan 12.

9.

Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production.

Moore MW, Cruz AR, LaVake CJ, Marzo AL, Eggers CH, Salazar JC, Radolf JD.

Infect Immun. 2007 Apr;75(4):2046-62. Epub 2007 Jan 12.

10.

Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.

Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I.

J Immunol. 2009 Oct 15;183(8):5279-92. doi: 10.4049/jimmunol.0901390. Epub 2009 Sep 30.

11.

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.

Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke AH.

J Immunol. 2015 Aug 1;195(3):1092-9. doi: 10.4049/jimmunol.1403173. Epub 2015 Jun 22.

12.

2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

Rimbach K, Kaiser S, Helm M, Dalpke AH, Eigenbrod T.

J Innate Immun. 2015;7(5):482-93. doi: 10.1159/000375460. Epub 2015 Mar 20.

13.

Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes.

Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA.

Arthritis Res Ther. 2017 Feb 28;19(1):39. doi: 10.1186/s13075-017-1237-9.

14.

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.

Hurst J, Prinz N, Lorenz M, Bauer S, Chapman J, Lackner KJ, von Landenberg P.

Immunobiology. 2009;214(8):683-91. doi: 10.1016/j.imbio.2008.12.003. Epub 2009 Feb 26.

PMID:
19249118
15.

Adaptor Protein-3-Mediated Trafficking of TLR2 Ligands Controls Specificity of Inflammatory Responses but Not Adaptor Complex Assembly.

Petnicki-Ocwieja T, Kern A, Killpack TL, Bunnell SC, Hu LT.

J Immunol. 2015 Nov 1;195(9):4331-40. doi: 10.4049/jimmunol.1501268. Epub 2015 Sep 30.

16.

Differences in TLR7/8 activation between monocytes and macrophages.

Eng HL, Hsu YY, Lin TM.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):319-325. doi: 10.1016/j.bbrc.2018.02.079. Epub 2018 Feb 12.

PMID:
29448098
17.

TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA.

Berger M, Ablasser A, Kim S, Bekeredjian-Ding I, Giese T, Endres S, Hornung V, Hartmann G.

J Immunother. 2009 Apr;32(3):262-71. doi: 10.1097/CJI.0b013e318198bd2a.

PMID:
19242374
18.

The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.

Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ.

Infect Immun. 2010 Jul;78(7):3144-53. doi: 10.1128/IAI.01070-09. Epub 2010 Apr 19.

19.

Induction of indoleamine 2,3-dioxygenase by Borrelia burgdorferi in human immune cells correlates with pathogenic potential.

Love AC, Schwartz I, Petzke MM.

J Leukoc Biol. 2015 Feb;97(2):379-90. doi: 10.1189/jlb.4A0714-339R. Epub 2014 Nov 24.

20.

Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice.

Belperron AA, Liu N, Booth CJ, Bockenstedt LK.

Front Cell Infect Microbiol. 2014 Jun 11;4:75. doi: 10.3389/fcimb.2014.00075. eCollection 2014.

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