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Items: 1 to 20 of 329

1.

Caspase-1 deficient mice are more susceptible to influenza A virus infection with PA variation.

Huang CH, Chen CJ, Yen CT, Yu CP, Huang PN, Kuo RL, Lin SJ, Chang CK, Shih SR.

J Infect Dis. 2013 Dec 1;208(11):1898-905. doi: 10.1093/infdis/jit381. Epub 2013 Jul 30.

PMID:
23901080
2.

The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice.

Hu J, Hu Z, Song Q, Gu M, Liu X, Wang X, Hu S, Chen C, Liu H, Liu W, Chen S, Peng D, Liu X.

J Virol. 2013 Mar;87(5):2660-72. doi: 10.1128/JVI.02891-12. Epub 2012 Dec 19.

3.

Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Song MS, Pascua PN, Lee JH, Baek YH, Park KJ, Kwon HI, Park SJ, Kim CJ, Kim H, Webby RJ, Webster RG, Choi YK.

J Virol. 2011 Jul;85(13):6275-86. doi: 10.1128/JVI.02125-10. Epub 2011 Apr 20.

4.

Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence.

Li C, Hatta M, Nidom CA, Muramoto Y, Watanabe S, Neumann G, Kawaoka Y.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4687-92. doi: 10.1073/pnas.0912807107. Epub 2010 Feb 22.

5.

Differences in cytokine production in human macrophages and in virulence in mice are attributable to the acidic polymerase protein of highly pathogenic influenza A virus subtype H5N1.

Sakabe S, Takano R, Nagamura-Inoue T, Yamashita N, Nidom CA, Quynh Le Mt, Iwatsuki-Horimoto K, Kawaoka Y.

J Infect Dis. 2013 Jan 15;207(2):262-71. doi: 10.1093/infdis/jis523. Epub 2012 Oct 4.

6.

Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals.

Fan S, Hatta M, Kim JH, Le MQ, Neumann G, Kawaoka Y.

J Virol. 2014 Dec;88(23):13737-46. doi: 10.1128/JVI.01081-14. Epub 2014 Sep 17.

7.

Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus.

Hsieh EF, Lin SJ, Mok CK, Chen GW, Huang CH, Wang YC, Chen TC, Chen CJ, Ojcius DM, Shih SR.

J Infect Dis. 2011 Sep 15;204(6):864-72. doi: 10.1093/infdis/jir435. Erratum in: J Infect Dis. 2011 Dec 15;204(12):1997.

PMID:
21849283
8.

An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.

Shelton H, Smith M, Hartgroves L, Stilwell P, Roberts K, Johnson B, Barclay W.

J Gen Virol. 2012 May;93(Pt 5):998-1006. doi: 10.1099/vir.0.039701-0. Epub 2012 Feb 8.

9.

Swine Influenza Virus PA and Neuraminidase Gene Reassortment into Human H1N1 Influenza Virus Is Associated with an Altered Pathogenic Phenotype Linked to Increased MIP-2 Expression.

Dlugolenski D, Jones L, Howerth E, Wentworth D, Tompkins SM, Tripp RA.

J Virol. 2015 May;89(10):5651-67. doi: 10.1128/JVI.00087-15. Epub 2015 Mar 11.

10.

Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes.

Hara K, Nakazono Y, Kashiwagi T, Hamada N, Watanabe H.

J Gen Virol. 2013 Nov;94(Pt 11):2406-16. doi: 10.1099/vir.0.053959-0. Epub 2013 Aug 12.

PMID:
23939981
11.

Molecular Determinants of Virulence and Stability of a Reporter-Expressing H5N1 Influenza A Virus.

Zhao D, Fukuyama S, Yamada S, Lopes TJ, Maemura T, Katsura H, Ozawa M, Watanabe S, Neumann G, Kawaoka Y.

J Virol. 2015 Nov;89(22):11337-46. doi: 10.1128/JVI.01886-15. Epub 2015 Sep 2.

12.

The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks.

Hu J, Hu Z, Mo Y, Wu Q, Cui Z, Duan Z, Huang J, Chen H, Chen Y, Gu M, Wang X, Hu S, Liu H, Liu W, Liu X, Liu X.

J Virol. 2013 Oct;87(20):11063-75. doi: 10.1128/JVI.00760-13. Epub 2013 Aug 7.

13.

NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens.

Tada T, Suzuki K, Sakurai Y, Kubo M, Okada H, Itoh T, Tsukamoto K.

J Virol. 2011 Feb;85(4):1834-46. doi: 10.1128/JVI.01648-10. Epub 2010 Dec 1.

14.

Comparative analysis of receptor-binding specificity and pathogenicity in natural reassortant and non-reassortant H3N2 swine influenza virus.

Cong Y, Sun Y, Wang W, Meng Q, Ran W, Zhu L, Yang G, Yang W, Yang L, Wang C, Ding Z.

Vet Microbiol. 2014 Jan 10;168(1):105-15. doi: 10.1016/j.vetmic.2013.11.007. Epub 2013 Nov 15.

PMID:
24305615
15.

Generation and characterization of influenza A viruses with altered polymerase fidelity.

Cheung PP, Watson SJ, Choy KT, Fun Sia S, Wong DD, Poon LL, Kellam P, Guan Y, Malik Peiris JS, Yen HL.

Nat Commun. 2014 Sep 3;5:4794. doi: 10.1038/ncomms5794.

16.

Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses.

Chen LM, Davis CT, Zhou H, Cox NJ, Donis RO.

PLoS Pathog. 2008 May 23;4(5):e1000072. doi: 10.1371/journal.ppat.1000072.

17.

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.

Gao H, Sun Y, Hu J, Qi L, Wang J, Xiong X, Wang Y, He Q, Lin Y, Kong W, Seng LG, Sun H, Pu J, Chang KC, Liu X, Liu J.

Sci Rep. 2015 Feb 5;5:8262. doi: 10.1038/srep08262.

18.

PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection.

Wang Q, Zhang S, Jiang H, Wang J, Weng L, Mao Y, Sekiguchi S, Yasui F, Kohara M, Buchy P, Deubel V, Xu K, Sun B, Toyoda T.

Virol J. 2012 Jun 8;9:106. doi: 10.1186/1743-422X-9-106.

19.

Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin.

Cline TD, Karlsson EA, Freiden P, Seufzer BJ, Rehg JE, Webby RJ, Schultz-Cherry S.

J Virol. 2011 Dec;85(23):12262-70. doi: 10.1128/JVI.05582-11. Epub 2011 Sep 14.

20.

Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice.

Rolling T, Koerner I, Zimmermann P, Holz K, Haller O, Staeheli P, Kochs G.

J Virol. 2009 Jul;83(13):6673-80. doi: 10.1128/JVI.00212-09. Epub 2009 Apr 29.

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