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Items: 1 to 20 of 116

1.

Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.

Choi G, Lee J, Ji JY, Woo J, Kang NS, Cho SY, Kim HR, Ha JD, Han SY.

Int J Oncol. 2013 Oct;43(4):1205-11. doi: 10.3892/ijo.2013.2035. Epub 2013 Jul 23.

PMID:
23900402
2.

Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor.

Park JB.

PLoS One. 2016 Mar 17;11(3):e0150392. doi: 10.1371/journal.pone.0150392. eCollection 2016.

3.

Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.

Grbesa I, Pajares MJ, Martínez-Terroba E, Agorreta J, Mikecin AM, Larráyoz M, Idoate MA, Gall-Troselj K, Pio R, Montuenga LM.

PLoS One. 2015 Apr 27;10(4):e0124670. doi: 10.1371/journal.pone.0124670. eCollection 2015.

4.

Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line.

Lima RT, Barron GA, Grabowska JA, Bermano G, Kaur S, Roy N, Vasconcelos MH, Lin PK.

Anticancer Agents Med Chem. 2013 Mar;13(3):414-21.

PMID:
23092269
5.

Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.

Mellini P, Carafa V, Di Rienzo B, Rotili D, De Vita D, Cirilli R, Gallinella B, Provvisiero DP, Di Maro S, Novellino E, Altucci L, Mai A.

ChemMedChem. 2012 Nov;7(11):1905-8. doi: 10.1002/cmdc.201200318.

PMID:
24155041
6.

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW.

Mol Cancer Ther. 2010 Apr;9(4):844-55. doi: 10.1158/1535-7163.MCT-09-0971. Epub 2010 Apr 6.

7.

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.

Ma L, Maruwge W, Strambi A, D'Arcy P, Pellegrini P, Kis L, de Milito A, Lain S, Brodin B.

Cell Death Dis. 2014 Oct 23;5:e1483. doi: 10.1038/cddis.2014.385.

8.

Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.

Singh S, Kumar PU, Thakur S, Kiran S, Sen B, Sharma S, Rao VV, Poongothai AR, Ramakrishna G.

Tumour Biol. 2015 Aug;36(8):6159-71. doi: 10.1007/s13277-015-3300-y. Epub 2015 Mar 21.

PMID:
25794641
9.

Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.

Sakai T, Matsumoto Y, Ishikawa M, Sugita K, Hashimoto Y, Wakai N, Kitao A, Morishita E, Toyoshima C, Hayashi T, Akiyama T.

Bioorg Med Chem. 2015 Jan 15;23(2):328-39. doi: 10.1016/j.bmc.2014.11.027. Epub 2014 Dec 2.

PMID:
25515955
10.

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF.

Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Erratum in: Oncogene. 2009 Feb 26;28(8):1168. Inhof, A [corrected to Imhof, A].

PMID:
19060927
11.

Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.

Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA Jr, Faller DV, Dai Y.

Int J Oncol. 2014 Nov;45(5):2128-36. doi: 10.3892/ijo.2014.2639. Epub 2014 Sep 3.

12.

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.

Huhtiniemi T, Salo HS, Suuronen T, Poso A, Salminen A, Leppänen J, Jarho E, Lahtela-Kakkonen M.

J Med Chem. 2011 Oct 13;54(19):6456-68. doi: 10.1021/jm200590k. Epub 2011 Sep 7.

PMID:
21895016
13.

Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.

Yoon YK, Ali MA, Wei AC, Choon TS, Osman H, Parang K, Shirazi AN.

Bioorg Med Chem. 2014 Jan 15;22(2):703-10. doi: 10.1016/j.bmc.2013.12.029. Epub 2013 Dec 19.

PMID:
24387981
14.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Suzuki T, Khan MN, Sawada H, Imai E, Itoh Y, Yamatsuta K, Tokuda N, Takeuchi J, Seko T, Nakagawa H, Miyata N.

J Med Chem. 2012 Jun 28;55(12):5760-73. doi: 10.1021/jm3002108. Epub 2012 Jun 12.

PMID:
22642300
15.

Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells.

Jin Y, Cao Q, Chen C, Du X, Jin B, Pan J.

BMC Cancer. 2015 Apr 7;15:226. doi: 10.1186/s12885-015-1282-1.

16.

Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity.

Zhang Y, Au Q, Zhang M, Barber JR, Ng SC, Zhang B.

Biochem Biophys Res Commun. 2009 Sep 4;386(4):729-33. doi: 10.1016/j.bbrc.2009.06.113. Epub 2009 Jun 25.

PMID:
19559674
17.

Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition.

Panathur N, Dalimba U, Koushik PV, Alvala M, Yogeeswari P, Sriram D, Kumar V.

Eur J Med Chem. 2013 Nov;69:125-38. doi: 10.1016/j.ejmech.2013.08.018. Epub 2013 Aug 19.

PMID:
24013412
18.

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.

Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB.

Eur J Med Chem. 2014 Apr 9;76:414-26. doi: 10.1016/j.ejmech.2014.02.003. Epub 2014 Feb 6.

19.

Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?

Körner S, Böselt S, Thau N, Rath KJ, Dengler R, Petri S.

Neurodegener Dis. 2013;11(3):141-52. doi: 10.1159/000338048. Epub 2012 Jul 10.

PMID:
22796962
20.

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