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Items: 1 to 20 of 111

1.

Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.

Choi NM, Loguercio S, Verma-Gaur J, Degner SC, Torkamani A, Su AI, Oltz EM, Artyomov M, Feeney AJ.

J Immunol. 2013 Sep 1;191(5):2393-402. doi: 10.4049/jimmunol.1301279. Epub 2013 Jul 29.

2.

Epigenetic modifications of the VH region after DJH recombination in Pro-B cells.

Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, Li S, Jiao J, Yu X, Lv Z, Ji Y.

Immunology. 2017 Oct;152(2):218-231. doi: 10.1111/imm.12758. Epub 2017 Jun 23.

PMID:
28502113
3.

Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

Medvedovic J, Ebert A, Tagoh H, Tamir IM, Schwickert TA, Novatchkova M, Sun Q, Huis In 't Veld PJ, Guo C, Yoon HS, Denizot Y, Holwerda SJ, de Laat W, Cogné M, Shi Y, Alt FW, Busslinger M.

Immunity. 2013 Aug 22;39(2):229-44. doi: 10.1016/j.immuni.2013.08.011.

4.

CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork NJ, Schlissel MS, Riblet R, Murre C, Feeney AJ.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9566-71. doi: 10.1073/pnas.1019391108. Epub 2011 May 23.

5.

Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

Verma-Gaur J, Torkamani A, Schaffer L, Head SR, Schork NJ, Feeney AJ.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17004-9. doi: 10.1073/pnas.1208398109. Epub 2012 Oct 1.

6.

CTCF-binding elements mediate control of V(D)J recombination.

Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.

Nature. 2011 Sep 11;477(7365):424-30. doi: 10.1038/nature10495.

7.

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.

Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12. doi: 10.1073/pnas.1015954107. Epub 2010 Dec 1.

8.

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

Ebert A, McManus S, Tagoh H, Medvedovic J, Salvagiotto G, Novatchkova M, Tamir I, Sommer A, Jaritz M, Busslinger M.

Immunity. 2011 Feb 25;34(2):175-87. doi: 10.1016/j.immuni.2011.02.005.

9.

Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Hesslein DG, Pflugh DL, Chowdhury D, Bothwell AL, Sen R, Schatz DG.

Genes Dev. 2003 Jan 1;17(1):37-42.

10.

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Volpi SA, Verma-Gaur J, Hassan R, Ju Z, Roa S, Chatterjee S, Werling U, Hou H Jr, Will B, Steidl U, Scharff M, Edelman W, Feeney AJ, Birshtein BK.

J Immunol. 2012 Mar 15;188(6):2556-66. doi: 10.4049/jimmunol.1102763. Epub 2012 Feb 17.

11.

Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.

Ebert A, Hill L, Busslinger M.

Adv Immunol. 2015;128:93-121. doi: 10.1016/bs.ai.2015.07.006. Epub 2015 Aug 13. Review.

PMID:
26477366
12.

Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.

Xu CR, Schaffer L, Head SR, Feeney AJ.

Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8685-90. doi: 10.1073/pnas.0711758105. Epub 2008 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20044.

13.
14.

Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements.

Choi Y, Greenberg SJ, Du TL, Ward PM, Overturf PM, Brecher ML, Ballow M.

Blood. 1996 Mar 15;87(6):2506-12.

16.

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.

Afshar R, Pierce S, Bolland DJ, Corcoran A, Oltz EM.

J Immunol. 2006 Feb 15;176(4):2439-47.

17.

Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar.

Yasuike M, de Boer J, von Schalburg KR, Cooper GA, McKinnel L, Messmer A, So S, Davidson WS, Koop BF.

BMC Genomics. 2010 Sep 2;11:486. doi: 10.1186/1471-2164-11-486.

18.

Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.

Puget N, Hirasawa R, Hu NS, Laviolette-Malirat N, Feil R, Khamlichi AA.

Mol Cell Biol. 2015 Feb;35(3):529-43. doi: 10.1128/MCB.00235-14. Epub 2014 Nov 17.

19.
20.

CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

Lin SG, Guo C, Su A, Zhang Y, Alt FW.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1815-20. doi: 10.1073/pnas.1424936112. Epub 2015 Jan 26.

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