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Oncoimmunology. 2013 Jun 1;2(6):e24500. Epub 2013 Apr 16.

Strategies for purging CD96+ stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia.

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1
Division of Stem Cell Transplantation and Immunotherapy; 2nd Department of Medicine; Christian-Albrechts-University of Kiel; Kiel, Germany.

Abstract

The persistence of leukemic stem cells (LSCs) in acute myeloid leukemia (AML) patients receiving chemotherapy may be responsible for the high frequency of relapse. The selective elimination of CD96+ AML-LSCs by means of CD96-specific monoclonal antibodies may be a promising therapeutic approach and revitalize autologous hematopoietic progenitor cell transplantation.

KEYWORDS:

CD96; acute myeloid leukemia; graft engineering; leukemic stem cells; purging; targeted therapy

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