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Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex.

Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS.

J Immunol. 2013 Sep 1;191(5):2126-33. doi: 10.4049/jimmunol.1301092. Epub 2013 Jul 26.


Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies.

Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, Gershwin ME.

Hepatology. 1996 Jul;24(1):97-103.


Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.

Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth MJ, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS.

J Autoimmun. 2011 Nov;37(3):209-16. doi: 10.1016/j.jaut.2011.06.001. Epub 2011 Jul 18.


Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

Braun S, Berg C, Buck S, Gregor M, Klein R.

World J Gastroenterol. 2010 Feb 28;16(8):973-81.


Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis.

Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, Björkland A, Tötterman TH, Peters M, Worman HJ, Ansari AA, Coppel RL, Gershwin ME.

Hepatology. 1997 May;25(5):1085-9.


Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies.

Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME.

J Immunol. 2003 May 15;170(10):5326-32.


Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis.

Csepregi A, Obermayer-Straub P, Kneip S, Kayser A, Loges S, Schmidt E, Nemesánszky E, Szalay F, Manns MP, Strassburg CP.

Clin Dev Immunol. 2003 Jun-Dec;10(2-4):173-81.


Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis.

Cha S, Leung PS, Coppel RL, Van de Water J, Ansari AA, Gershwin ME.

Hepatology. 1994 Sep;20(3):574-83.


Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex.

Moteki S, Leung PS, Dickson ER, Van Thiel DH, Galperin C, Buch T, Alarcon-Segovia D, Kershenobich D, Kawano K, Coppel RL, et al.

Hepatology. 1996 Mar;23(3):436-44.


Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid.

Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME.

J Immunol. 2005 May 1;174(9):5874-83.


Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA.

Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME.

J Autoimmun. 2013 Mar;41:79-86. doi: 10.1016/j.jaut.2012.12.007. Epub 2013 Jan 24.


Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis.

Reynoso-Paz S, Leung PS, Van De Water J, Tanaka A, Munoz S, Bass N, Lindor K, Donald PJ, Coppel RL, Ansari AA, Gershwin ME.

Hepatology. 2000 Jan;31(1):24-9.


Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.

Migliaccio C, Van de Water J, Ansari AA, Kaplan MM, Coppel RL, Lam KS, Thompson RK, Stevenson F, Gershwin ME.

Hepatology. 2001 Apr;33(4):792-801.


Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis.

Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth MJ, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS.

Hepatology. 2013 Apr;57(4):1498-508. doi: 10.1002/hep.26157. Epub 2013 Jan 29.


Monoclonal antibodies to mitochondrial E2 components define autoepitopes in primary biliary cirrhosis.

Migliaccio C, Nishio A, Van de Water J, Ansari AA, Leung PS, Nakanuma Y, Coppel RL, Gershwin ME.

J Immunol. 1998 Nov 15;161(10):5157-63.


Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse.

Sasaki M, Van De Water J, Kenny TP, Gallo ML, Leung PS, Nakanuma Y, Ansari AA, Coppel RL, Neuberger J, Gershwin ME.

Hepatology. 2001 Oct;34(4 Pt 1):631-7.


The peculiar autoimmunity of primary biliary cirrhosis.

Mackay IR, Whittingham S, Fida S, Myers M, Ikuno N, Gershwin ME, Rowley MJ.

Immunol Rev. 2000 Apr;174:226-37. Review.


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