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Items: 1 to 20 of 107

1.

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.

Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S.

Nat Genet. 2013 Sep;45(9):1004-12. doi: 10.1038/ng.2715. Epub 2013 Jul 28.

2.

Novel cilia-dependent pathway activates rapid cyst growth in autosomal dominant polycystic kidney disease.

Patankar JV.

Clin Genet. 2014 Mar;85(3):230-2. doi: 10.1111/cge.12285. Epub 2013 Oct 13. No abstract available.

PMID:
24111686
3.

Polycystic kidney disease: Cyst growth and cilia in ADPKD.

Carney EF.

Nat Rev Nephrol. 2013 Oct;9(10):555. doi: 10.1038/nrneph.2013.160. Epub 2013 Aug 13. No abstract available.

PMID:
23938593
4.

Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.

Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M.

J Hepatol. 2017 Mar;66(3):571-580. doi: 10.1016/j.jhep.2016.10.032. Epub 2016 Nov 5.

5.

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S.

Hum Mol Genet. 2008 Jun 1;17(11):1505-16. doi: 10.1093/hmg/ddn039. Epub 2008 Feb 7.

6.

Molecular basis of autosomal dominant polycystic kidney disease.

Al-Bhalal L, Akhtar M.

Adv Anat Pathol. 2005 May;12(3):126-33. Review.

PMID:
15900113
7.

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M.

Hepatology. 2010 May;51(5):1778-88. doi: 10.1002/hep.23511.

8.

The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.

Ye H, Wang X, Constans MM, Sussman CR, Chebib FT, Irazabal MV, Young WF Jr, Harris PC, Kirschner LS, Torres VE.

Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F677-F686. doi: 10.1152/ajprenal.00119.2017. Epub 2017 Jun 14.

PMID:
28615245
9.

Cyst formation following disruption of intracellular calcium signaling.

Kuo IY, DesRochers TM, Kimmerling EP, Nguyen L, Ehrlich BE, Kaplan DL.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14283-8. doi: 10.1073/pnas.1412323111. Epub 2014 Sep 16.

10.

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

Park EY, Sung YH, Yang MH, Noh JY, Park SY, Lee TY, Yook YJ, Yoo KH, Roh KJ, Kim I, Hwang YH, Oh GT, Seong JK, Ahn C, Lee HW, Park JH.

J Biol Chem. 2009 Mar 13;284(11):7214-22. doi: 10.1074/jbc.M805890200. Epub 2008 Dec 20.

11.

Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.

Wu G, Tian X, Nishimura S, Markowitz GS, D'Agati V, Park JH, Yao L, Li L, Geng L, Zhao H, Edelmann W, Somlo S.

Hum Mol Genet. 2002 Aug 1;11(16):1845-54.

PMID:
12140187
12.

Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.

Kim I, Ding T, Fu Y, Li C, Cui L, Li A, Lian P, Liang D, Wang DW, Guo C, Ma J, Zhao P, Coffey RJ, Zhan Q, Wu G.

J Am Soc Nephrol. 2009 Dec;20(12):2556-69. doi: 10.1681/ASN.2009030271. Epub 2009 Nov 25.

13.

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.

Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP.

Hum Mol Genet. 2009 Jan 1;18(1):151-63. doi: 10.1093/hmg/ddn325. Epub 2008 Oct 9.

14.

Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease.

Stroope A, Radtke B, Huang B, Masyuk T, Torres V, Ritman E, LaRusso N.

Am J Pathol. 2010 Mar;176(3):1282-91. doi: 10.2353/ajpath.2010.090658. Epub 2010 Jan 21.

15.

A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats.

Gallagher AR, Hoffmann S, Brown N, Cedzich A, Meruvu S, Podlich D, Feng Y, Könecke V, de Vries U, Hammes HP, Gretz N, Witzgall R.

J Am Soc Nephrol. 2006 Oct;17(10):2719-30. Epub 2006 Aug 30.

16.

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. doi: 10.1073/pnas.1301904110. Epub 2013 Jul 15.

17.

Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.

Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J.

J Am Soc Nephrol. 2006 Apr;17(4):1015-25.

18.

Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.

Fonseca JM, Bastos AP, Amaral AG, Sousa MF, Souza LE, Malheiros DM, Piontek K, Irigoyen MC, Watnick TJ, Onuchic LF.

Kidney Int. 2014 May;85(5):1137-50. doi: 10.1038/ki.2013.501. Epub 2014 Jan 15.

19.

Nedd9 restrains renal cystogenesis in Pkd1-/- mice.

Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. doi: 10.1073/pnas.1405362111. Epub 2014 Aug 19.

20.

miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.

Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10765-70. doi: 10.1073/pnas.1301693110. Epub 2013 Jun 12.

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