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Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.

Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH.

J Dent Res. 2013 Oct;92(10):911-7. doi: 10.1177/0022034513499350. Epub 2013 Jul 24.


Dynamic involvement of ATG5 in cellular stress responses.

Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.

Cell Death Dis. 2014 Oct 23;5:e1478. doi: 10.1038/cddis.2014.428.


Autophagy correlates with maintenance of salivary gland function following radiation.

Morgan-Bathke M, Hill GA, Harris ZI, Lin HH, Chibly AM, Klein RR, Burd R, Ann DK, Limesand KH.

Sci Rep. 2014 Jun 6;4:5206. doi: 10.1038/srep05206.


The Rapalogue, CCI-779, improves salivary gland function following radiation.

Morgan-Bathke M, Harris ZI, Arnett DG, Klein RR, Burd R, Ann DK, Limesand KH.

PLoS One. 2014 Dec 1;9(12):e113183. doi: 10.1371/journal.pone.0113183. eCollection 2014.


Physiological role of aquaporin 5 in salivary glands.

Hosoi K.

Pflugers Arch. 2016 Apr;468(4):519-39. doi: 10.1007/s00424-015-1749-6. Epub 2015 Nov 5. Review.


Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands.

Maruyama EO, Aure MH, Xie X, Myal Y, Gan L, Ovitt CE.

PLoS One. 2016 Jan 11;11(1):e0146711. doi: 10.1371/journal.pone.0146711. eCollection 2016.


Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation.

Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T, Menon AG.

J Biol Chem. 2001 Jun 29;276(26):23413-20. Epub 2001 Apr 4.


Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration.

Arany S, Catalán MA, Roztocil E, Ovitt CE.

Dev Biol. 2011 May 15;353(2):186-93. doi: 10.1016/j.ydbio.2011.02.025. Epub 2011 Mar 4.


TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation.

Yamamura Y, Motegi K, Kani K, Takano H, Momota Y, Aota K, Yamanoi T, Azuma M.

J Cell Mol Med. 2012 Aug;16(8):1766-75. doi: 10.1111/j.1582-4934.2011.01456.x.


Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo.

Alirezaei M, Flynn CT, Wood MR, Whitton JL.

Cell Host Microbe. 2012 Mar 15;11(3):298-305. doi: 10.1016/j.chom.2012.01.014.


Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

Ni HM, Woolbright BL, Williams J, Copple B, Cui W, Luyendyk JP, Jaeschke H, Ding WX.

J Hepatol. 2014 Sep;61(3):617-25. doi: 10.1016/j.jhep.2014.04.043. Epub 2014 May 9.


Use of inducible Atg5 deletion and expression cell lines in study of the pro-survival function of autophagy under starvation.

Chen B, Sun X, Zhang Y, Zhu XQ, Shen HM.

Biochem Biophys Res Commun. 2012 Oct 12;427(1):11-7. doi: 10.1016/j.bbrc.2012.08.117. Epub 2012 Aug 30.


Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.

Ni HM, Boggess N, McGill MR, Lebofsky M, Borude P, Apte U, Jaeschke H, Ding WX.

Toxicol Sci. 2012 Jun;127(2):438-50. doi: 10.1093/toxsci/kfs133. Epub 2012 Apr 5.


Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia.

Sukseree S, Rossiter H, Mildner M, Pammer J, Buchberger M, Gruber F, Watanapokasin R, Tschachler E, Eckhart L.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):689-94. doi: 10.1016/j.bbrc.2012.11.090. Epub 2012 Dec 2.


Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland.

Shan XF, Xu H, Cai ZG, Wu LL, Yu GY.

Int J Oral Sci. 2013 Dec;5(4):217-23. doi: 10.1038/ijos.2013.82. Epub 2013 Oct 25.


Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease.

Teos LY, Zheng CY, Liu X, Swaim WD, Goldsmith CM, Cotrim AP, Baum BJ, Ambudkar IS.

Gene Ther. 2016 Jul;23(7):572-9. doi: 10.1038/gt.2016.29. Epub 2016 Mar 11.


Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.

Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H.

Gastroenterology. 2015 Mar;148(3):626-638.e17. doi: 10.1053/j.gastro.2014.12.003. Epub 2014 Dec 11.


Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva.

Pan Y, Iwata F, Wang D, Muraguchi M, Ooga K, Ohmoto Y, Takai M, Cho G, Kang J, Shono M, Li XJ, Okamura K, Mori T, Ishikawa Y.

Biochim Biophys Acta. 2009 Jan 1;1790(1):49-56. doi: 10.1016/j.bbagen.2008.08.009. Epub 2008 Sep 10.


Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo.

Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C111-20. doi: 10.1152/ajpcell.90620.2007. Epub 2008 Apr 30.

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