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Items: 1 to 20 of 93

1.

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.

Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS.

Elife. 2013 Jul 16;2:e00857. doi: 10.7554/eLife.00857. Erratum in: Elife. 2013;2:e01252.

2.

Curcumin Binding to Beta Amyloid: A Computational Study.

Rao PP, Mohamed T, Teckwani K, Tin G.

Chem Biol Drug Des. 2015 Oct;86(4):813-20. doi: 10.1111/cbdd.12552. Epub 2015 Mar 24.

PMID:
25776887
3.

Inhibition of amyloid-β aggregation in Alzheimer's disease.

Wang Q, Yu X, Li L, Zheng J.

Curr Pharm Des. 2014;20(8):1223-43. Review.

PMID:
23713775
4.

Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.

Chen J, Armstrong AH, Koehler AN, Hecht MH.

J Am Chem Soc. 2010 Dec 1;132(47):17015-22. doi: 10.1021/ja107552s. Epub 2010 Nov 9.

5.

How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters.

Matsuzaki K.

Acc Chem Res. 2014 Aug 19;47(8):2397-404. doi: 10.1021/ar500127z. Epub 2014 Jul 16.

PMID:
25029558
6.

Interaction of Alzheimer's β-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation.

Di Scala C, Chahinian H, Yahi N, Garmy N, Fantini J.

Biochemistry. 2014 Jul 22;53(28):4489-502. doi: 10.1021/bi500373k. Epub 2014 Jul 11. Review.

PMID:
25000142
7.

The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease.

Savelieff MG, DeToma AS, Derrick JS, Lim MH.

Acc Chem Res. 2014 Aug 19;47(8):2475-82. doi: 10.1021/ar500152x. Epub 2014 Jul 31.

PMID:
25080056
8.

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease.

Drolle E, Hane F, Lee B, Leonenko Z.

Drug Metab Rev. 2014 May;46(2):207-23. doi: 10.3109/03602532.2014.882354. Epub 2014 Feb 5. Review.

PMID:
24495298
9.

A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates.

Wong HE, Qi W, Choi HM, Fernandez EJ, Kwon I.

ACS Chem Neurosci. 2011 Nov 16;2(11):645-57. doi: 10.1021/cn200056g. Epub 2011 Sep 6.

10.

Brain amyloid-β oligomers in ageing and Alzheimer's disease.

Lesné SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, Bennett DA, Ashe KH.

Brain. 2013 May;136(Pt 5):1383-98. doi: 10.1093/brain/awt062. Epub 2013 Apr 9.

11.

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.

Falker C, Hartmann A, Guett I, Dohler F, Altmeppen H, Betzel C, Schubert R, Thurm D, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M.

J Neurochem. 2016 Apr;137(1):88-100. doi: 10.1111/jnc.13514. Epub 2016 Mar 2.

12.

Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

Watson D, Castaño E, Kokjohn TA, Kuo YM, Lyubchenko Y, Pinsky D, Connolly ES Jr, Esh C, Luehrs DC, Stine WB, Rowse LM, Emmerling MR, Roher AE.

Neurol Res. 2005 Dec;27(8):869-81. Review.

PMID:
16354549
13.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
14.

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide.

Peters C, Fernandez-Perez EJ, Burgos CF, Espinoza MP, Castillo C, Urrutia JC, Streltsov VA, Opazo C, Aguayo LG.

Neurobiol Aging. 2013 Dec;34(12):2805-14. doi: 10.1016/j.neurobiolaging.2013.06.001. Epub 2013 Jul 12.

PMID:
23855983
15.

Understanding amyloid fibril nucleation and aβ oligomer/drug interactions from computer simulations.

Nguyen P, Derreumaux P.

Acc Chem Res. 2014 Feb 18;47(2):603-11. doi: 10.1021/ar4002075. Epub 2013 Dec 24. Review.

PMID:
24368046
16.

Molecular basis for amyloid-beta polymorphism.

Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43. doi: 10.1073/pnas.1112600108. Epub 2011 Sep 23.

17.

Development of a new distyrylbenzene-derivative amyloid-β-aggregation and fibril formation inhibitor.

Suzuki H, Ishigami A, Orimoto A, Matsuyama A, Handa S, Maruyama N, Yokoyama Y, Okuno H, Nakakoshi M.

Chem Pharm Bull (Tokyo). 2012;60(9):1164-70.

18.

A strategy for designing a peptide probe for detection of β-amyloid oligomers.

Hu Y, Su B, Kim CS, Hernandez M, Rostagno A, Ghiso J, Kim JR.

Chembiochem. 2010 Nov 22;11(17):2409-18. doi: 10.1002/cbic.201000435.

PMID:
21031399
19.

Surface-modified protein microspheres capture amyloid-β and inhibit its aggregation and toxicity.

Richman M, Wilk S, Skirtenko N, Perelman A, Rahimipour S.

Chemistry. 2011 Sep 26;17(40):11171-7. doi: 10.1002/chem.201101326. Epub 2011 Sep 2.

PMID:
21887833
20.

Molecular dynamics simulations of Aβ fibril interactions with β-sheet breaker peptides.

Bruce NJ, Chen D, Dastidar SG, Marks GE, Schein CH, Bryce RA.

Peptides. 2010 Nov;31(11):2100-8. doi: 10.1016/j.peptides.2010.07.015. Epub 2010 Aug 4.

PMID:
20691234

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