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Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

Choi E, Park PG, Lee HO, Lee YK, Kang GH, Lee JW, Han W, Lee HC, Noh DY, Lekomtsev S, Lee H.

Dev Cell. 2012 Feb 14;22(2):295-308. doi: 10.1016/j.devcel.2012.01.009.


Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.

Conde C, Osswald M, Barbosa J, Moutinho-Santos T, Pinheiro D, Guimarães S, Matos I, Maiato H, Sunkel CE.

EMBO J. 2013 Jun 12;32(12):1761-77. doi: 10.1038/emboj.2013.109. Epub 2013 May 17.


p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment.

Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK.

Mol Biol Cell. 2011 Nov;22(22):4236-46. doi: 10.1091/mbc.E11-03-0216. Epub 2011 Sep 30.


Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T.

Cancer Res. 2009 Jan 1;69(1):45-54. doi: 10.1158/0008-5472.CAN-07-6330.


Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.

Tipton AR, Ji W, Sturt-Gillespie B, Bekier ME 2nd, Wang K, Taylor WR, Liu ST.

J Biol Chem. 2013 Dec 6;288(49):35149-58. doi: 10.1074/jbc.M113.522375. Epub 2013 Oct 22.


Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT.

Nat Cell Biol. 2014 Dec;16(12):1257-64. doi: 10.1038/ncb3065. Epub 2014 Nov 17.


Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH.

EMBO J. 2003 Jun 16;22(12):2934-47.


Mad3/BubR1 phosphorylation during spindle checkpoint activation depends on both Polo and Aurora kinases in budding yeast.

Rancati G, Crispo V, Lucchini G, Piatti S.

Cell Cycle. 2005 Jul;4(7):972-80. Epub 2005 Jul 9.


Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy.

Tan CL, Teissier S, Gunaratne J, Quek LS, Bellanger S.

Cell Cycle. 2015;14(9):1459-70. doi: 10.1080/15384101.2015.1021519.


Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells.

Logarinho E, Bousbaa H, Dias JM, Lopes C, Amorim I, Antunes-Martins A, Sunkel CE.

J Cell Sci. 2004 Apr 1;117(Pt 9):1757-71. Epub 2004 Mar 16.


Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.

Bargiela-Iparraguirre J, Prado-Marchal L, Pajuelo-Lozano N, Jiménez B, Perona R, Sánchez-Pérez I.

Cell Cycle. 2014;13(22):3590-601. doi: 10.4161/15384101.2014.962952.


Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.

Ricke RM, van Deursen JM.

Semin Cell Dev Biol. 2011 Aug;22(6):559-65. doi: 10.1016/j.semcdb.2011.03.007. Epub 2011 Mar 23. Review.


Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.

von Schubert C, Cubizolles F, Bracher JM, Sliedrecht T, Kops GJ, Nigg EA.

Cell Rep. 2015 Jul 7;12(1):66-78. doi: 10.1016/j.celrep.2015.06.007. Epub 2015 Jun 25.


Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.

J Cell Biol. 2003 Apr 28;161(2):267-80.


Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.

Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ.

Dev Cell. 2012 Oct 16;23(4):745-55. doi: 10.1016/j.devcel.2012.09.005.


[Research progress on spindle assembly checkpoint gene BubR1].

Chen ZJ, Li F, Yang J.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Jul;40(4):446-50. Review. Chinese.


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