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Silencing of desmoplakin decreases connexin43/Nav1.5 expression and sodium current in HL‑1 cardiomyocytes.

Zhang Q, Deng C, Rao F, Modi RM, Zhu J, Liu X, Mai L, Tan H, Yu X, Lin Q, Xiao D, Kuang S, Wu S.

Mol Med Rep. 2013 Sep;8(3):780-6. doi: 10.3892/mmr.2013.1594. Epub 2013 Jul 18.


Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Liang FX, Li Z, Pfenniger A, Lübkemeier I, Keegan S, Fenyö D, Willecke K, Rothenberg E, Delmar M.

Cardiovasc Res. 2014 Nov 1;104(2):371-81. doi: 10.1093/cvr/cvu195. Epub 2014 Aug 18.


[Desmoplakin expression silencing affects cardiac voltage-gated sodium channel Nav1.5 in HL-1 cells].

Zhang Q, Deng C, Rao F, Liu X, Mai L, Zhu J, Tan H, Wu S.

Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jul;33(7):983-9. Chinese.


Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.

Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K.

Basic Res Cardiol. 2013 May;108(3):348. doi: 10.1007/s00395-013-0348-y. Epub 2013 Apr 5.


Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study.

Veeraraghavan R, Lin J, Keener JP, Gourdie R, Poelzing S.

Pflugers Arch. 2016 Oct;468(10):1651-61. doi: 10.1007/s00424-016-1861-2. Epub 2016 Aug 11.


Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations.

Fidler LM, Wilson GJ, Liu F, Cui X, Scherer SW, Taylor GP, Hamilton RM.

J Cell Mol Med. 2009 Oct;13(10):4219-28. doi: 10.1111/j.1582-4934.2008.00438.x. Epub 2008 Jul 26.


Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart.

Vreeker A, van Stuijvenberg L, Hund TJ, Mohler PJ, Nikkels PG, van Veen TA.

PLoS One. 2014 Apr 14;9(4):e94722. doi: 10.1371/journal.pone.0094722. eCollection 2014.


Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.

Chkourko HS, Guerrero-Serna G, Lin X, Darwish N, Pohlmann JR, Cook KE, Martens JR, Rothenberg E, Musa H, Delmar M.

Heart Rhythm. 2012 Jul;9(7):1133-1140.e6. doi: 10.1016/j.hrthm.2012.03.003. Epub 2012 Mar 7.


Gap junctions - guards of excitability.

Stroemlund LW, Jensen CF, Qvortrup K, Delmar M, Nielsen MS.

Biochem Soc Trans. 2015 Jun;43(3):508-12. doi: 10.1042/BST20150059. Review.


Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells.

Oxford EM, Musa H, Maass K, Coombs W, Taffet SM, Delmar M.

Circ Res. 2007 Sep 28;101(7):703-11. Epub 2007 Aug 2.


Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes.

Rizzo S, Lodder EM, Verkerk AO, Wolswinkel R, Beekman L, Pilichou K, Basso C, Remme CA, Thiene G, Bezzina CR.

Cardiovasc Res. 2012 Sep 1;95(4):409-18. doi: 10.1093/cvr/cvs219. Epub 2012 Jul 3.


The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions.

Gutstein DE, Liu FY, Meyers MB, Choo A, Fishman GI.

J Cell Sci. 2003 Mar 1;116(Pt 5):875-85.


Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.

Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG.

Cardiovasc Res. 2012 Apr 1;94(1):58-65. doi: 10.1093/cvr/cvs025. Epub 2012 Jan 27.


Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA.

Circ Res. 2006 Sep 15;99(6):646-55. Epub 2006 Aug 17.


Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model.

Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F.

Hum Mol Genet. 2014 Mar 1;23(5):1134-50. doi: 10.1093/hmg/ddt508. Epub 2013 Oct 9.


Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study.

Veeraraghavan R, Lin J, Hoeker GS, Keener JP, Gourdie RG, Poelzing S.

Pflugers Arch. 2015 Oct;467(10):2093-105. doi: 10.1007/s00424-014-1675-z. Epub 2015 Jan 13.


Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA.

Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.


Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart.

Dun W, Lowe JS, Wright P, Hund TJ, Mohler PJ, Boyden PA.

PLoS One. 2013 Oct 14;8(10):e78087. doi: 10.1371/journal.pone.0078087. eCollection 2013.


Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

Manias JL, Plante I, Gong XQ, Shao Q, Churko J, Bai D, Laird DW.

Cardiovasc Res. 2008 Dec 1;80(3):385-95. doi: 10.1093/cvr/cvn203. Epub 2008 Aug 4.


SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.

Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H.

Circ Res. 2011 Feb 4;108(3):294-304. doi: 10.1161/CIRCRESAHA.110.228312. Epub 2010 Dec 16.

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