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Items: 1 to 20 of 106

1.

Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA).

Müller S, Windhof IM, Maximov V, Jurkowski T, Jeltsch A, Förstner KU, Sharma CM, Gräf R, Nellen W.

Nucleic Acids Res. 2013 Oct;41(18):8615-27. doi: 10.1093/nar/gkt634. Epub 2013 Jul 22.

2.

The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu.

Shanmugam R, Aklujkar M, Schäfer M, Reinhardt R, Nickel O, Reuter G, Lovley DR, Ehrenhofer-Murray A, Nellen W, Ankri S, Helm M, Jurkowski TP, Jeltsch A.

Nucleic Acids Res. 2014 Jun;42(10):6487-96. doi: 10.1093/nar/gku256. Epub 2014 Apr 7.

3.

Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.

Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A.

RNA. 2008 Aug;14(8):1663-70. doi: 10.1261/rna.970408. Epub 2008 Jun 20.

4.

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.

Müller M, Hartmann M, Schuster I, Bender S, Thüring KL, Helm M, Katze JR, Nellen W, Lyko F, Ehrenhofer-Murray AE.

Nucleic Acids Res. 2015 Dec 15;43(22):10952-62. doi: 10.1093/nar/gkv980. Epub 2015 Sep 30.

5.

Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.

Becker M, Müller S, Nellen W, Jurkowski TP, Jeltsch A, Ehrenhofer-Murray AE.

Nucleic Acids Res. 2012 Dec;40(22):11648-58. doi: 10.1093/nar/gks956. Epub 2012 Oct 15.

6.

Developmentally regulated DNA methylation in Dictyostelium discoideum.

Katoh M, Curk T, Xu Q, Zupan B, Kuspa A, Shaulsky G.

Eukaryot Cell. 2006 Jan;5(1):18-25.

7.

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.

Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH.

Science. 2006 Jan 20;311(5759):395-8.

8.

Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi.

Kuhlmann M, Borisova BE, Kaller M, Larsson P, Stach D, Na J, Eichinger L, Lyko F, Ambros V, Söderbom F, Hammann C, Nellen W.

Nucleic Acids Res. 2005 Nov 10;33(19):6405-17. Print 2005.

9.

Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.

Elhardt W, Shanmugam R, Jurkowski TP, Jeltsch A.

Biochimie. 2015 May;112:66-72. doi: 10.1016/j.biochi.2015.02.022. Epub 2015 Mar 5.

PMID:
25747896
10.

In vitro tRNA methylation assay with the Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme.

Tovy A, Hofmann B, Helm M, Ankri S.

J Vis Exp. 2010 Oct 19;(44). pii: 2390. doi: 10.3791/2390.

11.

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.

Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F.

Genes Dev. 2010 Aug 1;24(15):1590-5. doi: 10.1101/gad.586710.

12.

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.

Tuorto F, Herbst F, Alerasool N, Bender S, Popp O, Federico G, Reitter S, Liebers R, Stoecklin G, Gröne HJ, Dittmar G, Glimm H, Lyko F.

EMBO J. 2015 Sep 14;34(18):2350-62. doi: 10.15252/embj.201591382. Epub 2015 Aug 13.

13.
14.

Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences.

Shanmugam R, Fierer J, Kaiser S, Helm M, Jurkowski TP, Jeltsch A.

Cell Discov. 2015 Jun 9;1:15010. doi: 10.1038/celldisc.2015.10. eCollection 2015.

15.

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

Tuorto F, Liebers R, Musch T, Schaefer M, Hofmann S, Kellner S, Frye M, Helm M, Stoecklin G, Lyko F.

Nat Struct Mol Biol. 2012 Sep;19(9):900-5. doi: 10.1038/nsmb.2357. Epub 2012 Aug 12.

PMID:
22885326
16.

A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.

Tovy A, Siman Tov R, Gaentzsch R, Helm M, Ankri S.

PLoS Pathog. 2010 Feb 19;6(2):e1000775. doi: 10.1371/journal.ppat.1000775.

17.

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8627-31. doi: 10.1073/pnas.1306723110. Epub 2013 May 2.

18.

Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase.

Jurkowski TP, Shanmugam R, Helm M, Jeltsch A.

Biochemistry. 2012 Jun 5;51(22):4438-44. Epub 2012 May 23.

PMID:
22591353
19.

DNA methylation in Drosophila--a critical evaluation.

Krauss V, Reuter G.

Prog Mol Biol Transl Sci. 2011;101:177-91. doi: 10.1016/B978-0-12-387685-0.00003-2.

PMID:
21507351
20.

Two substrates are better than one: dual specificities for Dnmt2 methyltransferases.

Jeltsch A, Nellen W, Lyko F.

Trends Biochem Sci. 2006 Jun;31(6):306-8. Epub 2006 May 6. Review.

PMID:
16679017

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