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Items: 1 to 20 of 197

1.

Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.

Kim J, Kim SK, Kim HK, Mattson MP, Hyun DH.

PLoS One. 2013 Jul 11;8(7):e69030. doi: 10.1371/journal.pone.0069030. Print 2013.

2.

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.

Hyun DH, Kim J, Moon C, Lim CJ, de Cabo R, Mattson MP.

Age (Dordr). 2012 Apr;34(2):359-70. doi: 10.1007/s11357-011-9245-1. Epub 2011 Apr 13.

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Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1.

Matsunaga T, Kamase K, Takasawa H, Yamaji Y, Endo S, El-Kabbani O, Ikari A.

Chem Biol Interact. 2018 Jan 5;279:10-20. doi: 10.1016/j.cbi.2017.10.028. Epub 2017 Nov 10.

PMID:
29108775
6.

Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

Hyun DH, Hunt ND, Emerson SS, Hernandez JO, Mattson MP, de Cabo R.

J Neurochem. 2007 Mar;100(5):1364-74. Epub 2007 Jan 22.

7.

Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.

Buranrat B, Prawan A, Kukongviriyapan U, Kongpetch S, Kukongviriyapan V.

World J Gastroenterol. 2010 May 21;16(19):2362-70.

8.

Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent.

Li JZ, Ke Y, Misra HP, Trush MA, Li YR, Zhu H, Jia Z.

Toxicol Appl Pharmacol. 2014 Dec 15;281(3):285-93. doi: 10.1016/j.taap.2014.10.012. Epub 2014 Oct 29.

PMID:
25448047
9.

Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.

Du J, Daniels DH, Asbury C, Venkataraman S, Liu J, Spitz DR, Oberley LW, Cullen JJ.

J Biol Chem. 2006 Dec 8;281(49):37416-26. Epub 2006 Oct 13.

10.

Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1).

Chan TS, Teng S, Wilson JX, Galati G, Khan S, O'Brien PJ.

Free Radic Res. 2002 Apr;36(4):421-7.

PMID:
12069106
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The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.

Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME.

J Biol Chem. 2017 Nov 3;292(44):18203-18216. doi: 10.1074/jbc.M117.813923. Epub 2017 Sep 15.

13.

Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure.

Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A.

PLoS One. 2010 Aug 24;5(8):e12359. doi: 10.1371/journal.pone.0012359.

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Redox imbalance and mitochondrial abnormalities in the diabetic lung.

Wu J, Jin Z, Yan LJ.

Redox Biol. 2017 Apr;11:51-59. doi: 10.1016/j.redox.2016.11.003. Epub 2016 Nov 17.

16.

The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.

Hwang JH, Kim YH, Noh JR, Gang GT, Kim KS, Chung HK, Tadi S, Yim YH, Shong M, Lee CH.

Arch Toxicol. 2015 Nov;89(11):2159-66. doi: 10.1007/s00204-014-1340-5. Epub 2014 Sep 17.

PMID:
25224400
17.

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

Dinkova-Kostova AT, Talalay P.

Arch Biochem Biophys. 2010 Sep 1;501(1):116-23. doi: 10.1016/j.abb.2010.03.019. Epub 2010 Mar 31. Review.

18.

High resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system.

Hall A, Larsen AK, Parhamifar L, Meyle KD, Wu LP, Moghimi SM.

Biochim Biophys Acta. 2013 Oct;1827(10):1213-25. doi: 10.1016/j.bbabio.2013.07.001. Epub 2013 Jul 11.

19.

An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer.

Liu F, Yu G, Wang G, Liu H, Wu X, Wang Q, Liu M, Liao K, Wu M, Cheng X, Hao H.

PLoS One. 2012;7(7):e42138. doi: 10.1371/journal.pone.0042138. Epub 2012 Jul 27.

20.

An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.

Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA.

Cancer Res. 2012 Jun 15;72(12):3038-47. doi: 10.1158/0008-5472.CAN-11-3135. Epub 2012 Apr 24.

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