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Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity.

Fang CP, Li ZC, Yang CH, Cheng JC, Yeh YJ, Sun TH, Li HC, Juang YL, Lo SY.

PLoS One. 2013 Jul 9;8(7):e68736. doi: 10.1371/journal.pone.0068736. Print 2013.


Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.

Borowski P, Kühl R, Laufs R, Schulze zur Wiesch J, Heiland M.

J Clin Virol. 1999 Jun;13(1-2):61-9.


Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis.

Sabri S, Idrees M, Rafique S, Ali A, Iqbal M.

Int J Infect Dis. 2014 Aug;25:38-44. doi: 10.1016/j.ijid.2014.01.010. Epub 2014 May 17.


Hepatitis C virus NS3 protein interacts with ELKS-{delta} and ELKS-{alpha}, members of a novel protein family involved in intracellular transport and secretory pathways.

Hidajat R, Nagano-Fujii M, Deng L, Tanaka M, Takigawa Y, Kitazawa S, Hotta H.

J Gen Virol. 2005 Aug;86(Pt 8):2197-208.


DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.

Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB.

Virology. 2013 Jan 20;435(2):385-94. doi: 10.1016/j.virol.2012.10.025. Epub 2012 Nov 5.


The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus.

Zhang Z, Harris D, Pandey VN.

J Virol. 2008 Jun;82(12):5761-73. doi: 10.1128/JVI.00064-08. Epub 2008 Apr 9.


A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication.

Benureau Y, Warter L, Malcolm BA, Martin A.

Virology. 2010 Oct 25;406(2):228-40. doi: 10.1016/j.virol.2010.07.014. Epub 2010 Aug 11.


The N-terminal helix α(0) of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex.

He Y, Weng L, Li R, Li L, Toyoda T, Zhong J.

Virology. 2012 Jan 20;422(2):214-23. doi: 10.1016/j.virol.2011.10.021. Epub 2011 Nov 14.


Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

Lai CK, Jeng KS, Machida K, Cheng YS, Lai MM.

Virology. 2008 Jan 20;370(2):295-309. Epub 2007 Oct 10.


Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.

Rahbin N, Frelin L, Aleman S, Hultcrantz R, Sällberg M, Brenndörfer ED.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):31-5. doi: 10.1016/j.bbrc.2013.02.075. Epub 2013 Feb 27.


Chimeric Sindbis viruses dependent on the NS3 protease of hepatitis C virus.

Filocamo G, Pacini L, Migliaccio G.

J Virol. 1997 Feb;71(2):1417-27.


Complex formation between hepatitis C virus NS2 and NS3 proteins.

Kiiver K, Merits A, Ustav M, Zusinaite E.

Virus Res. 2006 May;117(2):264-72. Epub 2005 Dec 1.


NS3 is a serine protease required for processing of hepatitis C virus polyprotein.

Tomei L, Failla C, Santolini E, De Francesco R, La Monica N.

J Virol. 1993 Jul;67(7):4017-26.


Cell transformation and proteome alteration in QSG7701 cells transfected with hepatitis C virus non-structural protein 3.

He Q, Cheng R, Chen Z, Xiao X, Xiao Z, Li C, Li B, Zhang P, Zheng H, Feng D.

Acta Biochim Biophys Sin (Shanghai). 2007 Oct;39(10):751-62.


Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.

Sun HY, Ou NY, Wang SW, Liu WC, Cheng TF, Shr SJ, Sun KT, Chang TT, Young KC.

PLoS One. 2011;6(9):e25530. doi: 10.1371/journal.pone.0025530. Epub 2011 Sep 28.


A genomic approach of the hepatitis C virus generates a protein interaction map.

Flajolet M, Rotondo G, Daviet L, Bergametti F, Inchauspé G, Tiollais P, Transy C, Legrain P.

Gene. 2000 Jan 25;242(1-2):369-79.


The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.

Prikhod'ko EA, Prikhod'ko GG, Siegel RM, Thompson P, Major ME, Cohen JI.

Virology. 2004 Nov 10;329(1):53-67.


In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation.

Pan RY, Hung TM, Kou YH, Chan NL, Chang MF, Chang SC.

FEBS Lett. 2010 Feb 5;584(3):482-6. doi: 10.1016/j.febslet.2009.11.090. Epub 2009 Dec 3.

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