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Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein.

Zhang C, Wang L, Thomas S, Wang K, Lin DH, Rinehart J, Wang WH.

J Biol Chem. 2013 Sep 6;288(36):26135-46. doi: 10.1074/jbc.M113.478453. Epub 2013 Jul 19.


KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).

Zhang C, Wang L, Zhang J, Su XT, Lin DH, Scholl UI, Giebisch G, Lifton RP, Wang WH.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11864-9. doi: 10.1073/pnas.1411705111. Epub 2014 Jul 28.


Caveolin-1 Deficiency Inhibits the Basolateral K+ Channels in the Distal Convoluted Tubule and Impairs Renal K+ and Mg2+ Transport.

Wang L, Zhang C, Su X, Lin DH, Wang W.

J Am Soc Nephrol. 2015 Nov;26(11):2678-90. doi: 10.1681/ASN.2014070658. Epub 2015 Apr 6.


KCNJ10 (Kir4.1) is expressed in the basolateral membrane of the cortical thick ascending limb.

Zhang C, Wang L, Su XT, Lin DH, Wang WH.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1288-96. doi: 10.1152/ajprenal.00687.2014. Epub 2015 Apr 1.


Disruption of KCNJ10 (Kir4.1) stimulates the expression of ENaC in the collecting duct.

Su XT, Zhang C, Wang L, Gu R, Lin DH, Wang WH.

Am J Physiol Renal Physiol. 2016 May 1;310(10):F985-93. doi: 10.1152/ajprenal.00584.2015. Epub 2016 Feb 17.


Kcnj10 is a major type of K+ channel in mouse corneal epithelial cells and plays a role in initiating EGFR signaling.

Wang L, Zhang C, Su X, Lin D.

Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C710-7. doi: 10.1152/ajpcell.00040.2014.


An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels.

Lourdel S, Paulais M, Cluzeaud F, Bens M, Tanemoto M, Kurachi Y, Vandewalle A, Teulon J.

J Physiol. 2002 Jan 15;538(Pt 2):391-404.


ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.

Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F682-F688. doi: 10.1152/ajprenal.00420.2016. Epub 2016 Nov 9.


PGF2α regulates the basolateral K channels in the distal convoluted tubule (DCT).

Wang L, Zhang C, Su XT, Lin DH, Wu P, Laniado Schwartzman M, Wang WH.

Am J Physiol Renal Physiol. 2017 Mar 29:ajprenal.00102.2017. doi: 10.1152/ajprenal.00102.2017. [Epub ahead of print]


KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.

Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, Sterner C, Tegtmeier I, Penton D, Baukrowitz T, Hulton SA, Witzgall R, Ben-Zeev B, Howie AJ, Kleta R, Bockenhauer D, Warth R.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14490-5. doi: 10.1073/pnas.1003072107. Epub 2010 Jul 22.


The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney.

Su XT, Wang WH.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F12-5. doi: 10.1152/ajprenal.00112.2016. Epub 2016 Apr 27. Review.


Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.

Paulais M, Bloch-Faure M, Picard N, Jacques T, Ramakrishnan SK, Keck M, Sohet F, Eladari D, Houillier P, Lourdel S, Teulon J, Tucker SJ.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10361-6. doi: 10.1073/pnas.1101400108. Epub 2011 Jun 1.


Basolateral Kir4.1 activity in the distal convoluted tubule regulates K secretion by determining NaCl cotransporter activity.

Wang WH.

Curr Opin Nephrol Hypertens. 2016 Sep;25(5):429-35. doi: 10.1097/MNH.0000000000000248.


Vasopressin-induced stimulation of the Na(+)-activated K(+) channels is responsible for maintaining the basolateral K(+) conductance of the thick ascending limb (TAL) in EAST/SeSAME syndrome.

Fan L, Wang X, Zhang D, Duan X, Zhao C, Zu M, Meng X, Zhang C, Su XT, Wang MX, Wang WH, Gu R.

Biochim Biophys Acta. 2015 Nov;1852(11):2554-62. doi: 10.1016/j.bbadis.2015.08.023. Epub 2015 Aug 28.


Role and mechanisms of regulation of the basolateral Kir 4.1/Kir 5.1K+ channels in the distal tubules.

Palygin O, Pochynyuk O, Staruschenko A.

Acta Physiol (Oxf). 2017 Jan;219(1):260-273. doi: 10.1111/apha.12703. Epub 2016 May 20. Review.


K+ channel currents in basolateral membrane of distal convoluted tubule of rabbit kidney.

Taniguchi J, Yoshitomi K, Imai M.

Am J Physiol. 1989 Feb;256(2 Pt 2):F246-54.


Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).

Lin DH, Yue P, Yarborough O 3rd, Scholl UI, Giebisch G, Lifton RP, Rinehart J, Wang WH.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4495-500. doi: 10.1073/pnas.1503437112. Epub 2015 Mar 24.


Regulation and function of potassium channels in aldosterone-sensitive distal nephron.

Wang WH, Yue P, Sun P, Lin DH.

Curr Opin Nephrol Hypertens. 2010 Sep;19(5):463-70. doi: 10.1097/MNH.0b013e32833c34ec. Review.


Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.

Scholl UI, Choi M, Liu T, Ramaekers VT, Häusler MG, Grimmer J, Tobe SW, Farhi A, Nelson-Williams C, Lifton RP.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5842-7. doi: 10.1073/pnas.0901749106. Epub 2009 Mar 16.


The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel.

Bandulik S, Schmidt K, Bockenhauer D, Zdebik AA, Humberg E, Kleta R, Warth R, Reichold M.

Pflugers Arch. 2011 Apr;461(4):423-35. doi: 10.1007/s00424-010-0915-0. Epub 2011 Jan 11. Review.


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